HCPCS Level II J2407: Oritavancin (Orbactiv) Injection, 10 mg

HCPCS Level II code J2407 represents a billed unit of oritavancin (Orbactiv) injection, 10 mg, used for intravenous administration of a single-dose or multi-dose regimen for serious Gram-positive bacterial infections; the service type is intravenous antibiotic administration, with the typical site of service being hospital inpatient, emergency department, or infusion center/outpatient clinic depending on clinical need and site capabilities.

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HCPCS Level II J2407: Oritavancin (Orbactiv) Injection, 10 mg

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Sign up for hcpcs J2407 policy alerts

Get alerted when payer policies referencing J2407 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult presenting to an outpatient infusion center or hospital outpatient department with a confirmed or suspected complicated Gram-positive bacterial skin and soft tissue infection (cSSTI) or other indicated Gram-positive infection requiring a single-dose long-acting intravenous lipoglycopeptide antibiotic. The patient often has one or more of the following: previous intolerance or failure of standard IV therapy (for example, vancomycin), limited venous access making multi-day therapy impractical, social factors limiting outpatient parenteral antibiotic therapy adherence, or a need to avoid prolonged hospitalization.

Workflow:

Initial evaluation in emergency department, clinic, or inpatient ward including history, physical exam, and wound assessment.
Obtain cultures (blood and wound) and baseline labs (CBC, renal and hepatic panels) to assess suitability for oritavancin.
Allergy review and verification that no concurrent intravenous unfractionated heparin is required within 120 hours due to interference with coagulation tests.
Prescribing clinician orders J2407 for oritavancin, documents indication (e.g., cSSTI, cellulitis), and selects appropriate site of service (outpatient infusion center, hospital outpatient department, or inpatient when clinically indicated).
Pharmacy prepares the single-dose infusion per manufacturer and institutional protocols; nursing verifies identity, informs patient about potential infusion-related reactions, and administers per infusion instructions.
Monitor vital signs during and after infusion for infusion-related reactions and monitor coagulation tests interpretation as needed for up to 120 hours post-dose.
Document dose administration, lot number, and any adverse reactions. Arrange follow-up (telephone or clinic) to assess clinical response and review culture results for therapy adjustment.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Commonly used to report the infusion administration time for an IV antibiotic when initial infusion time falls within 1 hour.
`96366`	Intravenous infusion, each additional hour	Used if infusion time for oritavancin extends beyond the first hour and payer requires reporting of extended infusion time.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used if institutional practice administers medication by IM route (oritavancin is IV — include only if an alternative route is documented, generally not applicable).
`36415`	Collection of venous blood by venipuncture	Performed for baseline labs and culture draws prior to or after infusion.
`99070`	Supplies and materials (e.g., drugs requiring additional supplies when not included with the main service)	Used to report additional non-billable supplies related to infusion if payer permits separate charging.

Related Modifiers

6 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
163WX0601X	Otorhinolaryngology & Head-Neck Registered Nurse	Nursing Service Providers · Registered Nurse
174M00000X	Veterinarian	A doctor of veterinary medicine, trained and authorized to practice veterinarian medicine and surgery.
3416A0800X	Air Ambulance	Transportation Services · Ambulance
2278P1004X	Pulmonary Diagnostics Certified Respiratory Therapist	Included in the area of pulmonary diagnostics are the following; collection and analysis of physiological specimens, interpretation of physiological d…

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Workflow:

Initial evaluation in emergency department, clinic, or inpatient ward including history, physical exam, and wound assessment.
Obtain cultures (blood and wound) and baseline labs (CBC, renal and hepatic panels) to assess suitability for oritavancin.
Allergy review and verification that no concurrent intravenous unfractionated heparin is required within 120 hours due to interference with coagulation tests.
Prescribing clinician orders J2407 for oritavancin, documents indication (e.g., cSSTI, cellulitis), and selects appropriate site of service (outpatient infusion center, hospital outpatient department, or inpatient when clinically indicated).
Pharmacy prepares the single-dose infusion per manufacturer and institutional protocols; nursing verifies identity, informs patient about potential infusion-related reactions, and administers per infusion instructions.
Monitor vital signs during and after infusion for infusion-related reactions and monitor coagulation tests interpretation as needed for up to 120 hours post-dose.
Document dose administration, lot number, and any adverse reactions. Arrange follow-up (telephone or clinic) to assess clinical response and review culture results for therapy adjustment.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Commonly used to report the infusion administration time for an IV antibiotic when initial infusion time falls within 1 hour.
`96366`	Intravenous infusion, each additional hour	Used if infusion time for oritavancin extends beyond the first hour and payer requires reporting of extended infusion time.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used if institutional practice administers medication by IM route (oritavancin is IV — include only if an alternative route is documented, generally not applicable).
`36415`	Collection of venous blood by venipuncture	Performed for baseline labs and culture draws prior to or after infusion.
`99070`	Supplies and materials (e.g., drugs requiring additional supplies when not included with the main service)	Used to report additional non-billable supplies related to infusion if payer permits separate charging.

Related Modifiers

6 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
163WX0601X	Otorhinolaryngology & Head-Neck Registered Nurse	Nursing Service Providers · Registered Nurse
174M00000X	Veterinarian	A doctor of veterinary medicine, trained and authorized to practice veterinarian medicine and surgery.
3416A0800X	Air Ambulance	Transportation Services · Ambulance
2278P1004X	Pulmonary Diagnostics Certified Respiratory Therapist	Included in the area of pulmonary diagnostics are the following; collection and analysis of physiological specimens, interpretation of physiological d…

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J2407: Oritavancin (Orbactiv) Injection, 10 mg

Sign up for hcpcs J2407 policy alerts

HCPCS Level II J2407: Oritavancin (Orbactiv) Injection, 10 mg

Sign up for hcpcs J2407 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does billing code J2407 represent and where is it typically administered?

Which CPT or other procedure codes are commonly billed alongside J2407 for administration and related services?

In what clinical scenarios is oritavancin (J2407) typically used according to the page content?

Which billing modifiers are relevant to J2407 and when would they be applied?

Which payers are commonly associated with coverage and reimbursement discussions for J2407, and does the page provide reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does billing code J2407 represent and where is it typically administered?

Which CPT or other procedure codes are commonly billed alongside J2407 for administration and related services?

In what clinical scenarios is oritavancin (J2407) typically used according to the page content?

Which billing modifiers are relevant to J2407 and when would they be applied?

Which payers are commonly associated with coverage and reimbursement discussions for J2407, and does the page provide reimbursement rates?

References