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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j1670-tetanus-immune-globulin-injection-up-to-250-units
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    HCPCS Level II J1670: Injection, Tetanus Immune Globulin, Human, up to 250 Units

    HCPCS Level II code J1670 describes an injectable formulation of tetanus immune globulin, human, up to 250 units, intended for passive immunization to provide immediate antibody protection against tetanus; the service is an injection typically administered in outpatient clinics, emergency departments, or other ambulatory care settings when immediate post-exposure prophylaxis is indicated.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old adult presents to an urgent care clinic after sustaining a puncture wound from a rusty nail while gardening. The patient’s tetanus immunization history is uncertain and they have not received a tetanus toxoid-containing vaccine in the past five years. The clinician performs wound assessment, documents tetanus risk factors (e.g., contaminated wound, devitalized tissue), and determines passive immunization is indicated in addition to active immunization. Medication administration is ordered for tetanus immune globulin, human, up to 250 units (J1670). The drug is prepared by the clinic’s licensed nurse or pharmacist and administered via intramuscular injection in the deltoid or gluteal muscle depending on patient age and muscle mass. Vital signs and allergy status are confirmed before administration. The patient is observed for immediate adverse reactions for 15–30 minutes post-injection and given discharge instructions including follow-up for tetanus toxoid vaccination series and wound care. Documentation includes indication, lot number, units administered (capped at 250 units for J1670), route, site, consent, and any immediate adverse event.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99202Office or other outpatient visit for the evaluation and management of a new patient, typically 15–29 minutesE/M visit where wound assessment, decision to administer tetanus immune globulin (J1670), and documentation occur.
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesCommon visit code for follow-up or evaluation of a wound and administration of J1670.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed to report the act of administering an IM injection of tetanus immune globulin when payer requires an administration code in addition to the drug J-code.
    80053Comprehensive metabolic panelLaboratory tests commonly ordered if clinical status warrants baseline metabolic assessment prior to immunoglobulin in patients with comorbidities.
    99070Supplies and materials (e.g., syringes, gloves) used during patient care, over and above those usually included with the serviceUsed to report expendable supplies associated with drug preparation and administration if payer allows separate reporting.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    246Q00000XPathology Specialist/Technologist(1) An individual educated and trained in clinical chemistry, microbiology or other biological sciences; and in gathering data on the blood, tissues, …
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    175L00000XHomeopathA provider who is educated and trained in a system of therapeutics in which diseases are treated by drugs which are capable of producing in healthy pe…
    2279G0305XGeriatric Care Registered Respiratory TherapistCare of older patients who have age and/or disease related decremental pulmonary changes. Diagnosis and treatment is very important for this group si…
    163WS0121XPlastic Surgery Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    17 rows

    ICD-10-CM CodeDescription
    A48.1Legionnaires' disease
    B34.9Viral infection, unspecified
    J03.90Acute tonsillitis, unspecified
    J06.9Acute upper respiratory infection, unspecified
    L03.90Cellulitis, unspecified
    M79.2Neuralgia and neuritis, unspecified
    O98.511Other viral diseases complicating pregnancy, first trimester
    R22.9Localized swelling, mass and lump, unspecified
    R50.9Fever, unspecified
    S01.81XALaceration without foreign body of other part of head, initial encounter

    Showing 1–10 of 17

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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