HCPCS Level II J1573: Hepatitis B Immune Globulin Injection, IV 0.5 mL

HCPCS Level II code J1573 denotes a 0.5 mL intravenous dose of hepatitis B immune globulin (Hepagam B). This medication-specific code is used to bill for the injectable product administered to provide short-term passive immunity to hepatitis B after exposure or for certain prophylactic indications. Nationally, accurate coding for immune globulins matters for patient safety, inventory control, and consistent payment for high-cost biologic injectables.

Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for use of hepatitis B immune globulin, common sites of service for intravenous administration, and payer coverage considerations. Where available, benchmarking content addresses unit-based billing, typical settings such as hospital infusion centers and clinics, and the role of this HCPCS Level II code in capturing the medication component of care.

This publication summarizes how J1573 is used in billing workflows and what elements are typically needed on the service line. Data not available in the input is flagged as such; the piece focuses on national-level interpretation of the code, clinical context, and payer coverage scope rather than state-specific policy or step-by-step clinical guidance.

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Billing Code Overview

HCPCS Level II code J1573 represents an intravenous injection of hepatitis B immune globulin (Hepagam B) in a volume of 0.5 mL per unit. This code describes the medication administration itself rather than broader visit or facility services.

Service type: Intravenous medication administration / injectable immunoglobulin therapy

Typical site of service: Hospital inpatient or outpatient infusion center, emergency department, or clinic-based infusion suite

Data not available in the input.

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HCPCS Level II J1573: Hepatitis B Immune Globulin Injection, IV 0.5 mL

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Billing Code Overview

Service type: Intravenous medication administration / injectable immunoglobulin therapy

Typical site of service: Hospital inpatient or outpatient infusion center, emergency department, or clinic-based infusion suite

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A patient presents to an outpatient infusion center or hospital for passive immunization after a known or suspected exposure to hepatitis B virus (HBV). Typical scenarios include a neonate born to an HBsAg-positive mother, a healthcare worker with a recent needle-stick from an HBV-positive source, or an unvaccinated adult with recent household or sexual exposure to a person with acute hepatitis B. The product described by J1573 is hepatitis B immune globulin (Hepagam B) supplied as 0.5 ml for intravenous administration. Clinical workflow: initial evaluation and exposure risk assessment; verification of maternal or source HBV status and patient's prior vaccination/serology (e.g., HBsAb, HBsAg); informed consent and documentation of indication; preparation of IV access; administration of the immune globulin dose per weight-based or manufacturer dosing guidance; observation for immediate adverse reactions (30–60 minutes); documentation of lot number and expiration for cold-chain tracking; scheduling of hepatitis B vaccination series if indicated (e.g., at 0, 1–2, and 6 months for postexposure prophylaxis when recommended). Typical sites of service are an outpatient infusion center, emergency department, labor and delivery unit (for neonatal prophylaxis), or inpatient hospital setting for occupational exposures requiring urgent treatment.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z20.822`	Contact with and (suspected) exposure to hepatitis B	Primary indication for postexposure prophylaxis with hepatitis B immune globulin.
`P04.311`	Newborn, newborn affected by maternal hepatitis B antigen positive	Indicates neonatal exposure requiring immediate HBIG administration after birth.
`Z23`	Encounter for immunization	Used when administration is part of prophylactic immunization strategy following exposure.
`Z77.21`	Contact with and (suspected) exposure to potentially hazardous body fluids	Occupational or household exposure prompting HBIG use.
`B16.9`	Acute hepatitis B without hepatic coma, unspecified	May represent the source patient diagnosis; relevant for determining need for prophylaxis in contacts.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, therapeutic, (eg, antibiotics, antivirals), initial, up to 1 hour	Used when an infusion center documents the initial IV infusion encounter for administration of biologic agents; may be reported if facility requires infusion administration coding alongside the drug HCPCS `J1573` when infusion time meets requirements.
`96366`	Intravenous infusion, each additional hour	Use if administration of IV immune globulin extends beyond one hour and additional infusion time codes are billable per payer rules.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used for concurrent injections such as hepatitis B vaccine if administered IM during the same encounter (vaccination itself has other specific CPT codes when billed).
`90471`	Immunization administration (vaccines/toxoids); one single vaccine/non-component viral or bacterial vaccine	Used when hepatitis B vaccine is administered in conjunction with HBIG as part of postexposure prophylaxis and billed separately for vaccine administration.
`99214`	Office or other outpatient visit for the evaluation and management of an established patient, moderate complexity	Used for pre-administration evaluation and counseling when applicable and documented per E/M guidelines.

Related Modifiers

6 rows

Modifier
23
52
53
62
78
80

Related Provider Taxonomies

8 rows

Taxonomy Code
207Q00000X
163W00000X
207P00000X
364S00000X
335U00000X
2080P0210X
2472E0500X
164W00000X

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS J0120: Injection, Tetracycline, Up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS J0122: Injection, Eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS J0131: Injection Acetaminophen, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS J0134: Injection, Acetaminophen (Fresenius Kabi), 10 mg

Showing 1–10 of 991

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z20.822`	Contact with and (suspected) exposure to hepatitis B	Primary indication for postexposure prophylaxis with hepatitis B immune globulin.
`P04.311`	Newborn, newborn affected by maternal hepatitis B antigen positive	Indicates neonatal exposure requiring immediate HBIG administration after birth.
`Z23`	Encounter for immunization	Used when administration is part of prophylactic immunization strategy following exposure.
`Z77.21`	Contact with and (suspected) exposure to potentially hazardous body fluids	Occupational or household exposure prompting HBIG use.
`B16.9`	Acute hepatitis B without hepatic coma, unspecified	May represent the source patient diagnosis; relevant for determining need for prophylaxis in contacts.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, therapeutic, (eg, antibiotics, antivirals), initial, up to 1 hour	Used when an infusion center documents the initial IV infusion encounter for administration of biologic agents; may be reported if facility requires infusion administration coding alongside the drug HCPCS `J1573` when infusion time meets requirements.
`96366`	Intravenous infusion, each additional hour	Use if administration of IV immune globulin extends beyond one hour and additional infusion time codes are billable per payer rules.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used for concurrent injections such as hepatitis B vaccine if administered IM during the same encounter (vaccination itself has other specific CPT codes when billed).
`90471`	Immunization administration (vaccines/toxoids); one single vaccine/non-component viral or bacterial vaccine	Used when hepatitis B vaccine is administered in conjunction with HBIG as part of postexposure prophylaxis and billed separately for vaccine administration.
`99214`	Office or other outpatient visit for the evaluation and management of an established patient, moderate complexity	Used for pre-administration evaluation and counseling when applicable and documented per E/M guidelines.

Related Modifiers

6 rows

Modifier
23
52
53
62
78
80

Related Provider Taxonomies

8 rows

Taxonomy Code
207Q00000X
163W00000X
207P00000X
364S00000X
335U00000X
2080P0210X
2472E0500X
164W00000X

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS J0120: Injection, Tetracycline, Up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS J0122: Injection, Eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS J0131: Injection Acetaminophen, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS J0134: Injection, Acetaminophen (Fresenius Kabi), 10 mg

Showing 1–10 of 991

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.