HCPCS Level II J0888: Injection, epoetin beta 1 microgram (non-ESRD)

HCPCS Level II code J0888 describes an injection of epoetin beta, dosed at 1 microgram, intended for non-ESRD (non–end-stage renal disease) uses; the service is a therapeutic biologic drug administration typically delivered via injection in outpatient clinic, physician office, or infusion center and is billed per microgram unit. Data not available in the input.

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HCPCS Level II J0888: Injection, epoetin beta 1 microgram (non-ESRD)

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Get alerted when payer policies referencing J0888 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with chemotherapy-induced anemia or anemia due to chronic disease (non-ESRD) receiving subcutaneous or intravenous epoetin beta therapy to raise hemoglobin and reduce transfusion needs. The patient is seen in an oncology infusion clinic, hematology outpatient clinic, or hospital outpatient department. The prescribing clinician (medical oncologist or hematologist) documents baseline hemoglobin, iron studies, transfusion history, and treatment intent. Nursing verifies dose, prepares the injectable vial or syringe, and administers J0888 per manufacturer dosing (billed per microgram units). Clinical monitoring includes vital signs during administration, periodic hemoglobin checks, and dose adjustments. Billing uses the HCPCS Level II code J0888 for the drug units administered; documentation must support indication, dose, route, date of service, and supervising provider. Typical sites of service are outpatient infusion centers, physician offices, and hospital outpatient departments. Common clinical modifiers and payer-specific requirements are applied at claim submission as appropriate.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Often billed for the professional administration of a subcutaneous epoetin beta injection when payer requires an administration code
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single drug	May be used when epoetin beta is administered intravenously in an infusion setting alongside chemotherapy
`36415`	Collection of venous blood by venipuncture	Used for pre-treatment and monitoring hemoglobin and iron studies prior to epoetin beta dosing
`85025`	Blood count; complete (CBC) automated and automated differential WBC count	Common laboratory monitoring test performed to evaluate hemoglobin response
`99199`	Unlisted special service, procedure or report	Rarely used for reporting nonstandard infusion-related services when no specific CPT exists

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
27	Modifier 27 indicates a separate, subsequent outpatient hospital E/M service provided to the same patient on the same date by a different provider in a hospital outpatient setting. It is a…	- Use modifier -27 on facility (hospital outpatient/ambulatory service center) claims to report a subsequent, separate, and distinct outpatient E/M service provided to the same patient on the same…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207RR0500X	Rheumatology Physician	An internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
122400000X	Denturist	A denturist is a licensed professional that serves patients with removable dental prosthetic oral health needs. A licensed denturist is trained in rem…
332BP3500X	Parenteral & Enteral Nutrition Supplies (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
2080T0004X	Pediatric Transplant Hepatology Physician	A pediatrician with expertise in transplant hepatology encompasses the special knowledge and skill required of pediatric gastroenterologists to care f…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C81.90	Hodgkin lymphoma, unspecified, unspecified site
C82.90	Follicular lymphoma, unspecified, unspecified site
C83.90	Non-follicular (diffuse) lymphoma, unspecified, unspecified site
C90.00	Multiple myeloma not having achieved remission
C91.10	Chronic lymphocytic leukemia of B-cell type not having achieved remission
C94.6	Myelodysplastic disease, not elsewhere classified
D46.9	Myelodysplastic syndrome, unspecified
D47.1	Chronic myeloproliferative disease
D50.0	Iron deficiency anemia secondary to blood loss (chronic)
D50.8	Other iron deficiency anemias

Showing 1–10 of 27

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Often billed for the professional administration of a subcutaneous epoetin beta injection when payer requires an administration code
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single drug	May be used when epoetin beta is administered intravenously in an infusion setting alongside chemotherapy
`36415`	Collection of venous blood by venipuncture	Used for pre-treatment and monitoring hemoglobin and iron studies prior to epoetin beta dosing
`85025`	Blood count; complete (CBC) automated and automated differential WBC count	Common laboratory monitoring test performed to evaluate hemoglobin response
`99199`	Unlisted special service, procedure or report	Rarely used for reporting nonstandard infusion-related services when no specific CPT exists

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
27	Modifier 27 indicates a separate, subsequent outpatient hospital E/M service provided to the same patient on the same date by a different provider in a hospital outpatient setting. It is a…	- Use modifier -27 on facility (hospital outpatient/ambulatory service center) claims to report a subsequent, separate, and distinct outpatient E/M service provided to the same patient on the same…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
207RR0500X	Rheumatology Physician	An internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
122400000X	Denturist	A denturist is a licensed professional that serves patients with removable dental prosthetic oral health needs. A licensed denturist is trained in rem…
332BP3500X	Parenteral & Enteral Nutrition Supplies (DME)	Suppliers · Durable Medical Equipment & Medical Supplies
2080T0004X	Pediatric Transplant Hepatology Physician	A pediatrician with expertise in transplant hepatology encompasses the special knowledge and skill required of pediatric gastroenterologists to care f…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
C81.90	Hodgkin lymphoma, unspecified, unspecified site
C82.90	Follicular lymphoma, unspecified, unspecified site
C83.90	Non-follicular (diffuse) lymphoma, unspecified, unspecified site
C90.00	Multiple myeloma not having achieved remission
C91.10	Chronic lymphocytic leukemia of B-cell type not having achieved remission
C94.6	Myelodysplastic disease, not elsewhere classified
D46.9	Myelodysplastic syndrome, unspecified
D47.1	Chronic myeloproliferative disease
D50.0	Iron deficiency anemia secondary to blood loss (chronic)
D50.8	Other iron deficiency anemias

Showing 1–10 of 27

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J0888: Injection, epoetin beta 1 microgram (non-ESRD)

Sign up for hcpcs J0888 policy alerts

HCPCS Level II J0888: Injection, epoetin beta 1 microgram (non-ESRD)

Sign up for hcpcs J0888 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS J0888 describe and where is it typically used?

What clinical and documentation elements are required when billing J0888?

Which modifiers should be considered when submitting a claim for J0888?

What related CPT codes and services are commonly billed with J0888?

Which ICD‑10 diagnoses are typically associated with billing J0888?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS J0888 describe and where is it typically used?

What clinical and documentation elements are required when billing J0888?

Which modifiers should be considered when submitting a claim for J0888?

What related CPT codes and services are commonly billed with J0888?

Which ICD‑10 diagnoses are typically associated with billing J0888?

References