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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0699-cefiderocol-injection-10mg
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    HCPCS J0699: Injection, cefiderocol, 10 mg

    HCPCS Level II code J0699 represents a billed unit for injection of cefiderocol, 10 mg, typically reported for administration of this intravenous antibiotic product in inpatient or outpatient acute care settings such as hospitals, infusion centers, or emergency departments where parenteral antimicrobial therapy is provided.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A hospitalized adult patient with a confirmed or suspected multi-drug resistant Gram-negative bacillus infection (for example, complicated urinary tract infection, hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia, or complicated intra-abdominal infection) receives intravenous cefiderocol as targeted antimicrobial therapy. The decision to use J0699 (injection, cefiderocol, 10 mg) follows microbiology data showing susceptibility to cefiderocol or empiric use when other agents are contraindicated. The typical workflow: infectious disease consultation or hospitalist documents indication and dose; pharmacy compounds the vial(s) and records lot numbers; nursing administers the infusion via peripheral IV or central venous catheter over the manufacturer-recommended infusion time; observation for infusion reaction and therapeutic response occurs during and after dosing; documentation includes dose, route, infusion time, lot number, and any applicable modifiers for billing (for example, modifier JW to report discarded drug or QX for services performed by a certified registered nurse anesthetist when applicable). Typical site of service is an inpatient acute care hospital or an acute inpatient rehabilitation setting; outpatient infusion center or skilled nursing facility may also administer cefiderocol for outpatient parenteral antibiotic therapy (OPAT). Patient scenario example: a 67-year-old with chronic kidney disease and ventilator-associated pneumonia due to carbapenem-resistant Pseudomonas aeruginosa is started on cefiderocol with renal-adjusted dosing and daily nursing documentation of renal function and clinical response.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, initial, up to 1 hourUsed for the initial infusion encounter when cefiderocol administration is billed per infusion encounter in outpatient infusion settings
    96366Intravenous infusion, each additional hourUsed when infusion time extends beyond the initial hour and additional hourly infusion billing is appropriate
    96374Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscularOccasionally used if intramuscular antibiotic injection were clinically indicated (not typical for cefiderocol)
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderRelevant when a central line is placed to deliver prolonged IV cefiderocol therapy
    99231Subsequent hospital care, per day, for evaluation and managementUsed for daily physician evaluation of an inpatient receiving cefiderocol as part of ongoing care

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    3336C0002XClinic PharmacyA pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
    207SC0300XClinical Cytogenetics PhysicianA clinical cytogeneticist demonstrates competence in providing laboratory diagnostic and clinical interpretive services dealing with cellular componen…
    176P00000XFuneral DirectorA person, usually an embalmer, whose business is to arrange for the burial or cremation of the dead and to assist at the funeral rites.
    227900000XRegistered Respiratory TherapistA Registered Respiratory Therapist (RRT) is an advanced therapist who has passed standardized written and clinical simulation examinations administere…
    1744G0900XGraphics DesignerOther Service Providers · Specialist

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    A02.1Salmonella sepsis
    A41.01Sepsis due to Methicillin susceptible Staphylococcus aureus
    A41.02Sepsis due to Methicillin resistant Staphylococcus aureus
    A41.4Sepsis due to anaerobes
    A41.51Sepsis due to Escherichia coli [E. coli]
    A41.52Sepsis due to Pseudomonas
    A41.9Sepsis, unspecified organism
    A49.9Bacterial infection, unspecified
    A54.01Gonococcal cystitis and urethritis, unspecified
    A54.02Gonococcal vulvovaginitis, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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