J0592 Buprenorphine Injection HCPCS Reimbursement | OpenPayer

Summary & Overview

HCPCS Level II J0592: Injection of Buprenorphine Hydrochloride, 0.1 mg

HCPCS Level II code J0592 denotes the injection of buprenorphine hydrochloride, 0.1 mg, an injectable form of a partial opioid agonist used in clinical settings that require tight dosing control. Nationally, accurate coding for injectable buprenorphine matters for appropriate drug utilization tracking, payer adjudication, and outpatient and inpatient medication cost reporting. Key payers included in this overview are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise explanation of what HCPCS Level II code J0592 covers, the typical clinical contexts and sites of service where it is billed, and the payer landscape relevant to coverage and claims processing. The publication outlines common billing considerations, typical modifiers used with drug administration claims (listed separately), and references to related billing concepts. This resource is intended to inform revenue cycle, coding professionals, and policy analysts about the code’s clinical meaning, billing placement, and national relevance. Data not available in the input is noted where applicable.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareJ0592HCPCS Level IIbuprenorphineinjectable medicationdrug administrationoutpatient serviceshospital outpatientmedication coding

Billing Code Overview

HCPCS Level II code J0592 represents an injection of buprenorphine hydrochloride, 0.1 mg. This code describes a specific single-dose pharmaceutical administration of buprenorphine formulated for injection.

Service type: Medication administration (injectable pharmacologic therapy)
Typical site of service: Ambulatory clinic, physician office, outpatient infusion center, or inpatient hospital setting where injectable medications are administered

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with opioid use disorder or acute severe pain being managed in an outpatient addiction clinic, emergency department, or ambulatory surgical center who requires administration of a controlled, measured dose of injectable buprenorphine hydrochloride. The clinical workflow begins with assessment by a physician, nurse practitioner, or physician assistant to confirm indication (for example, opioid use disorder requiring induction or stabilization, or acute pain when sublingual/patch forms are not feasible). The provider documents medical necessity, reviews current medications and recent opioid use to reduce precipitated withdrawal risk, and obtains informed consent. The medication order for J0592 (buprenorphine hydrochloride injection, 0.1 mg) is entered into the electronic medical record with dose, route (typically intramuscular or subcutaneous), and administration site. A licensed clinician prepares the injection using standard aseptic technique, verifies patient identity, and administers the medication while monitoring vital signs and observing for signs of opioid withdrawal, sedation, respiratory depression, or allergic reaction. Post‑administration observation time varies by setting: brief monitoring in outpatient addiction clinics, longer observation in emergency departments, or recovery area monitoring in ambulatory surgical centers. Documentation includes indication, dosage, lot number, expiration date, injection site, patient response, and any adverse events. Billing uses the HCPCS Level II code J0592 with applicable modifiers to indicate circumstances such as professional component, unusual procedural services, or administration on behalf of another provider or supplier.

Coding Specifications

Modifier	Description	When to Use

HCPCS J2402: Chloroprocaine Hydrochloride Injection, per 1 mg

HCPCS-J1439-FERRIC-CARBOXYMALTOSE-INJECTION-1MG

HCPCS J1439: Ferric Carboxymaltose Injection, 1 mg

HCPCS-J7609-ALBUTEROL-INHALATION-SOLUTION-COMPOUNDED-UNIT-DOSE-1MG

HCPCS Level II J7609: Albuterol Inhalation Solution, Compounded, Unit Dose, 1 mg

HCPCS-J2679-FLUPHENAZINE-INJECTION-1-25-MG

HCPCS Level II J2679: Fluphenazine HCl Injection, 1.25 mg

HCPCS-J7660-ISOPROTERENOL-INHALATION-SOLUTION-DME-UNIT-DOSE

HCPCS J7660: Isoproterenol HCl Inhalation Solution, DME Unit-Dose

HCPCS-J0360-HYDRALAZINE-INJECTION-20MG

HCPCS J0360: Injection, Hydralazine HCl up to 20 mg

HCPCS-J3130-TESTOSTERONE-ENANTHATE-INJECTION-UP-TO-200-MG

HCPCS Level II J3130: Injection, Testosterone Enanthate, Up to 200 mg

HCPCS-J7509-METHYLPREDNISOLONE-ORAL-4MG

HCPCS J7509: Methylprednisolone Oral, 4 mg

HCPCS-J2175-MEPERIDINE-INJECTION-100MG

HCPCS J2175: Injection, Meperidine Hydrochloride, per 100 mg

HCPCS-J3031-FREMANEZUMAB-INJECTION-PER-MG

HCPCS J3031: Injection, fremanezumab‑vfrm, 1 mg

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Taxonomy Code	Specialty	Notes
`208D00000X`	Addiction Medicine Physician	Commonly manages buprenorphine for opioid use disorder and prescribes injectable formulations.
`2084P0800X`	Pain Medicine Physician	Uses buprenorphine formulations for refractory pain management when indicated.
`363L00000X`	Nurse Practitioner	Frequently administers and monitors injectable medications in outpatient clinics and ED settings.
`367500000X`	Physician Assistant	Performs assessments, documents, and may administer or supervise administration in ambulatory settings.
`222100000X`	Anesthesiology Physician	May be involved when buprenorphine is used perioperatively or in pain clinics.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`F11.10`	Opioid abuse, uncomplicated	Common indication for buprenorphine therapy during stabilization and treatment of opioid use disorder.
`F11.20`	Opioid dependence, uncomplicated	Frequently used when initiating or maintaining buprenorphine treatment for dependence.
`F11.21`	Opioid dependence, in remission	Relevant for maintenance dosing or follow-up injectable therapy planning.
`G89.3`	Neoplasm related pain (acute or chronic)	Buprenorphine may be used for moderate to severe cancer-related pain when other opioids are ineffective or contraindicated.
`R52`	Pain, unspecified	General pain diagnosis where buprenorphine injection could be considered when oral routes are unsuitable.
`T40.0X5A`	Poisoning by opium, accidental (initial encounter)	May be relevant in emergency settings where buprenorphine is used as part of management for opioid toxicity or withdrawal support.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly reported for administration of injectable medications in outpatient settings when a drug HCPCS code like `J0592` is billed for the drug itself; `96372` documents the injection administration service.
`99401`	Preventive medicine counseling, individual; approximately 15 minutes	Used when brief counseling is provided related to substance use disorder treatment initiation during the same encounter.
`99406`	Smoking and tobacco use cessation counseling visit, intermediate, 3–10 minutes	May be billed if concurrent counseling addressing tobacco cessation is provided during the visit managing opioid use disorder.
`99213`	Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutes	Captures the evaluation and management service when `J0592` is administered in an office or clinic setting.
`96361`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	May be relevant when the patient requires IV fluids or supportive care concurrent with injectable buprenorphine administration in certain settings.
`99199`	Unlisted anesthesia procedure or service	Occasionally used for unusual monitoring or sedation services related to administration if no specific code applies.

`00`	Default / No modifier	Use when no specific modifier applies to the service billed with `J0592`.
`52`	Reduced services	When the full planned dose or service was partially reduced or not completed.
`53`	Discontinued service	When administration was started but discontinued due to patient condition.
`59`	Data not provided in the input.	Data not provided in the input.
`78`	Return to operating room	When follow‑on operative procedure is performed by the same physician (rarely applicable to injectable medication alone).
`80`	Assistant surgeon	When an assistant surgeon is documented and reportable (more relevant in surgical settings where `J0592` given perioperatively).
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for Medicare	When the service is performed by or on behalf of an advanced practice clinician under Medicare rules.
`JW`	Drug discarded/not administered to any patient	When part of the vial/ampule is discarded and must be reported per payer policies.
`JZ`	No drug administered	When no medication was administered despite billing (use per payer rules).
`QX`	Requirements met for CRNA with physician direction	When a certified registered nurse anesthetist provides the administration under applicable supervision rules.
`QY`	Medical direction of two, three, or four concurrent anesthesia procedures	When billing interactions involve medical direction (rare for this injection).
`TG`	Via telemedicine (synchronous)	When a supervising clinician directs administration remotely per payer telemedicine guidelines.

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