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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0576-buprenorphine-extended-release-brixadi-1mg-injection
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    HCPCS J0576: Buprenorphine Extended-Release (Brixadi) Injection, 1 mg

    HCPCS Level II code J0576 describes an injectable formulation of buprenorphine extended-release (Brixadi), billed per 1 mg unit for treatment of opioid use disorder; the service is an injection typically administered in outpatient behavioral health clinics, addiction treatment centers, or physician offices that provide medication-assisted treatment (ambulatory/outpatient setting).

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old patient with moderate to severe opioid use disorder presents to an outpatient addiction medicine clinic for administration of long-acting injectable buprenorphine (Brixadi). The patient is medically stabilized on sublingual buprenorphine or has completed a brief inpatient induction and meets criteria for transition to extended-release injectable therapy to improve adherence. The clinic visit includes verification of identity, review of recent urine drug screen, assessment of withdrawal symptoms and cravings, documentation of informed consent for injection therapy, and review of allergies and concomitant medications. The medication J0576 (buprenorphine extended-release, Brixadi) is prepared by licensed staff and administered via subcutaneous injection in the upper arm, abdomen, or buttock depending on formulation and clinical judgment. After injection, the patient is observed in clinic for a monitored period (typically 15–30 minutes) for immediate adverse reactions, with vitals recorded and counseling provided regarding injection-site care, overdose risk, and follow-up scheduling. Subsequent visits occur at recommended intervals (weekly to monthly) for clinical monitoring, behavioral counseling, and repeat injections as clinically indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)Often used to report the administration service for an injectable medication when payer rules require a CPT for administration separate from the J‑code.
    99401Preventive medicine counseling, individual, 15 minutes (historical example)Counseling and brief behavioral interventions provided at visits; ensure correct current CPT code per payer for substance use counseling.
    99406Smoking and tobacco use cessation counseling visit, intermediate, 3–10 minutesRepresents brief counseling codes clinicians may use for adjunct behavioral interventions; select appropriate counseling CPTs for substance use as applicable.
    99408Alcohol and/or substance abuse structured screening and brief intervention services, 15–30 minutesUsed when structured SBIRT services are delivered at the visit in conjunction with medication administration.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityCommon E/M code for routine follow-up visits where injection J0576 is administered and interval assessment is performed.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    164W00000XLicensed Practical NurseAn individual with post-high school vocational training and practical experience in the provision of nursing care at a level less than that required f…
    332BC3200XCustomized Equipment (DME)Suppliers · Durable Medical Equipment & Medical Supplies
    261QR0401XComprehensive Outpatient Rehabilitation Facility (CORF)Ambulatory Health Care Facilities · Clinic/Center
    207RE0101XEndocrinology, Diabetes & Metabolism PhysicianAn internist who concentrates on disorders of the internal (endocrine) glands such as the thyroid and adrenal glands. This specialist also deals with …
    207RC0001XClinical Cardiac Electrophysiology PhysicianA field of special interest within the subspecialty of cardiovascular disease, specialty of Internal Medicine, which involves intricate technical proc…

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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