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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0285-amphotericin-b-50mg-injection
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    HCPCS J0285: Injection, amphotericin B, 50 mg

    HCPCS Level II code J0285 represents a 50 mg injection of amphotericin B, used for systemic antifungal therapy; the service is an antimicrobial injection typically administered as an intravenous infusion in hospital inpatient, hospital outpatient, or infusion clinic settings.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult or pediatric patient with a serious systemic fungal infection (for example, invasive candidiasis, cryptococcal meningitis, or severe systemic aspergillosis) who requires parenteral antifungal therapy. The patient presents to an inpatient hospital unit, intensive care unit, or infusion center after diagnosis is established by culture, histopathology, or clinical criteria indicating a life‑threatening fungal infection or when an azole therapy is contraindicated. Amphotericin B is prepared by pharmacy as a preservative‑free IV admixture in compatible fluid and is administered via a central venous catheter or peripheral IV under monitoring for infusion‑related reactions, nephrotoxicity, electrolyte disturbances, and hemodynamic changes. Typical workflow steps: medication order entry and weight‑based dose calculation, pharmacy compounding and labeling, verification of infusion pump settings, baseline laboratory evaluation (renal function, electrolytes), administration with premedication as indicated (e.g., acetaminophen, diphenhydramine), continuous nursing monitoring during infusion, and follow‑up labs to assess toxicity and therapeutic response. The usual site of service is inpatient hospital (including ICU), hospital outpatient infusion center, or specialty ambulatory infusion clinic.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drugUsed for administration of intravenous antifungal agents when infusion time is within the specified duration and for billing infusion administration separately
    96415Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary infusion)Used to report extended infusion time beyond the initial hour for amphotericin B infusions requiring prolonged administration
    96360Intravenous infusion, hydration; initial, 31 minutes to 1 hourUsed when significant intravenous hydration is provided before, during, or after amphotericin B to mitigate nephrotoxicity
    96365Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hourUsed when amphotericin B is administered and the infusion is reported as a therapeutic IV infusion in non‑chemotherapy administration pathways
    36415Collection of venous blood by venipunctureUsed for baseline and follow‑up laboratory monitoring (renal function, electrolytes) associated with amphotericin B therapy
    99070Supplies and materials (e.g., saline flushes, tubing) provided by the physician over and above those usually included with the office visitUsed to bill for additional disposable supplies associated with outpatient infusion when payer allows

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208800000XUrology PhysicianA urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    225100000XPhysical TherapistPhysical therapists (PTs) are licensed health care professionals who diagnose and treat individuals of all ages, from newborns to the very oldest, who…
    237600000XAudiologist-Hearing Aid FitterAn audiologist/hearing aid fitter is the professional who specializes in evaluating and treating people with hearing loss, conducts a wide variety of …
    364SF0001XFamily Health Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    225400000XRehabilitation PractitionerA health care practitioner who trains or retrains individuals disabled by disease or injury to help them attain their maximum functional capacity.
    156FX1100XOphthalmic Technician/TechnologistAn ophthalmic technician/technologist assists ophthalmologists by performing ophthalmic clinical functions, including administering eye exams, adminis…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.52Sepsis due to Pseudomonas
    A41.9Sepsis, unspecified organism
    A48.3Toxic shock syndrome
    A49.9Bacterial infection, unspecified
    A52.9Late syphilis, unspecified
    B20Human immunodeficiency virus [HIV] disease
    B35.0Tinea barbae and tinea capitis
    B35.1Tinea unguium
    B35.6Tinea cruris
    B36.8Other specified superficial mycoses

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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