HCPCS Level II J0216: Injection, Alfentanil Hydrochloride, 500 mcg

HCPCS Level II code J0216 describes a single injectable dose of alfentanil hydrochloride, 500 micrograms, an intravenous analgesic used for short-duration pain control during procedures; the service is an injection typically administered in hospital inpatient, hospital outpatient, ambulatory surgical centers, or procedural/sedation suites for procedural analgesia or short diagnostic/interventional procedures.

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HCPCS Level II J0216: Injection, Alfentanil Hydrochloride, 500 mcg

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Get alerted when payer policies referencing J0216 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient receiving J0216 (injection, alfentanil hydrochloride, 500 micrograms) is an adult undergoing a short-duration painful procedure in the outpatient surgical or procedural setting where a short-acting opioid is required for analgesia or sedation. Common scenarios include monitored anesthesia care for brief diagnostic procedures (e.g., endoscopy, ophthalmologic procedures, minor ENT interventions), perioperative analgesia for short ambulatory surgeries, or intra-procedural pain control in the ambulatory surgical center.

The clinical workflow begins with pre-procedure evaluation by the proceduralist or anesthesia provider who documents indication for short-acting opioid analgesia, medical history, airway assessment, and informed consent. On the day of service, standard monitoring (continuous pulse oximetry, blood pressure, ECG as indicated) is applied. A qualified provider (anesthesiologist, CRNA, or proceduralist in accordance with facility policy) administers J0216 intravenously, titrating to effect for analgesia or adjunctive sedation. Post-administration monitoring occurs in the PACU or recovery area until discharge criteria are met. Documentation includes medication name, dose, route, time, patient's response, vital signs, and any airway or respiratory interventions.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`00400`	Anesthesia for procedures on integumentary system, head, and neck; not otherwise specified	Anesthesia codes like `00400` may be billed by anesthesia providers when providing monitored anesthesia care that includes administration of `J0216` for short procedures
`00790`	Anesthesia for upper gastrointestinal endoscopic procedures, endoscope introduced proximal to duodenum	Anesthesia services for endoscopy procedures where `J0216` may be used as an adjunct for analgesia/sedation
`99152`	Moderate sedation services provided by the same physician performing the procedure, initial 15 minutes	CPT for moderate (conscious) sedation often billed when procedural sedation includes intravenous opioids such as `J0216`
`99153`	Each additional 15 minutes of moderate sedation	Use to report additional time for ongoing sedation when `J0216` effect continues and additional monitoring time is required
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Not commonly used for intravenous alfentanil but included to indicate injection administration codes for billing contexts where applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
93	Modifier 93 denotes that a billed service was delivered synchronously via audio-only telecommunications (real-time telephone or other audio-only system). The AMA added modifier 93 in CPT Appendix A…	- When to use: Apply modifier -93 when a synchronous, real-time, two-way patient–provider encounter is conducted entirely via audio-only (telephone or other real-time interactive audio-only…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
163WL0100X	Lactation Consultant (Registered Nurse)	Nursing Service Providers · Registered Nurse
207RR0500X	Rheumatology Physician	An internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
1223X2210X	Orofacial Pain Dentistry	A dentist who assesses, diagnoses, and treats patients with complex chronic orofacial pain and dysfunction disorders, oromotor and jaw behavior disord…

Related ICD-10-CM Codes

21 rows

ICD-10-CM Code	Description
F32.9	Major depressive disorder, single episode, unspecified
F41.9	Anxiety disorder, unspecified
G89.0	Central pain syndrome
I21.9	Acute myocardial infarction, unspecified
I63.9	Cerebral infarction, unspecified
K21.9	Gastro-esophageal reflux disease without esophagitis
M17.0	Bilateral primary osteoarthritis of knee
M17.11	Unilateral primary osteoarthritis, right knee
M19.071	Primary osteoarthritis, right ankle and foot
M54.12	Radiculopathy, cervical region

Showing 1–10 of 21

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`00400`	Anesthesia for procedures on integumentary system, head, and neck; not otherwise specified	Anesthesia codes like `00400` may be billed by anesthesia providers when providing monitored anesthesia care that includes administration of `J0216` for short procedures
`00790`	Anesthesia for upper gastrointestinal endoscopic procedures, endoscope introduced proximal to duodenum	Anesthesia services for endoscopy procedures where `J0216` may be used as an adjunct for analgesia/sedation
`99152`	Moderate sedation services provided by the same physician performing the procedure, initial 15 minutes	CPT for moderate (conscious) sedation often billed when procedural sedation includes intravenous opioids such as `J0216`
`99153`	Each additional 15 minutes of moderate sedation	Use to report additional time for ongoing sedation when `J0216` effect continues and additional monitoring time is required
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Not commonly used for intravenous alfentanil but included to indicate injection administration codes for billing contexts where applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
93	Modifier 93 denotes that a billed service was delivered synchronously via audio-only telecommunications (real-time telephone or other audio-only system). The AMA added modifier 93 in CPT Appendix A…	- When to use: Apply modifier -93 when a synchronous, real-time, two-way patient–provider encounter is conducted entirely via audio-only (telephone or other real-time interactive audio-only…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
163WL0100X	Lactation Consultant (Registered Nurse)	Nursing Service Providers · Registered Nurse
207RR0500X	Rheumatology Physician	An internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
1223X2210X	Orofacial Pain Dentistry	A dentist who assesses, diagnoses, and treats patients with complex chronic orofacial pain and dysfunction disorders, oromotor and jaw behavior disord…

Related ICD-10-CM Codes

21 rows

ICD-10-CM Code	Description
F32.9	Major depressive disorder, single episode, unspecified
F41.9	Anxiety disorder, unspecified
G89.0	Central pain syndrome
I21.9	Acute myocardial infarction, unspecified
I63.9	Cerebral infarction, unspecified
K21.9	Gastro-esophageal reflux disease without esophagitis
M17.0	Bilateral primary osteoarthritis of knee
M17.11	Unilateral primary osteoarthritis, right knee
M19.071	Primary osteoarthritis, right ankle and foot
M54.12	Radiculopathy, cervical region

Showing 1–10 of 21

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J0216: Injection, Alfentanil Hydrochloride, 500 mcg

Sign up for hcpcs J0216 policy alerts

HCPCS Level II J0216: Injection, Alfentanil Hydrochloride, 500 mcg

Sign up for hcpcs J0216 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J0216 represent?

In what clinical scenarios is J0216 commonly used?

Which related CPT codes might appear on the same claim as J0216?

What documentation elements are highlighted for J0216 administration?

Which payers are associated with coverage for J0216 and does this page give reimbursement details?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J0216 represent?

In what clinical scenarios is J0216 commonly used?

Which related CPT codes might appear on the same claim as J0216?

What documentation elements are highlighted for J0216 administration?

Which payers are associated with coverage for J0216 and does this page give reimbursement details?

References