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    OpenPayerBilling CodesProcedures / Professional ServicesHCPCS hcpcs-g2083-esketamine-nasal-established-patient-outpatient-visit
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    HCPCS G2083: Supervised Esketamine Nasal Self-Administration Visit

    HCPCS Level II code G2083 describes an office or other outpatient visit for evaluation and management of an established patient requiring physician or qualified health care professional supervision for administration of greater than 56 mg esketamine nasal self-administration, including a 2-hour post-administration observation; the service type is supervised procedural E/M with post-administration monitoring and the typical site of service is an office or other outpatient clinic where supervised nasal medication administration and observation can be provided.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old established patient with treatment-resistant major depressive disorder presents to an outpatient behavioral health infusion/administration clinic for supervised self-administration of esketamine nasal spray. The patient has previously tolerated lower doses and now requires a dose greater than 56 mg per the treatment plan. The visit is scheduled for an office outpatient evaluation and management encounter with a supervising physician or other qualified health care professional present for oversight.

    Pre-visit workflow includes verification of indication, review of recent psychiatric assessment, medication reconciliation, baseline vital signs, baseline depression symptom rating (for example, PHQ-9), and confirmation of informed consent and REMS program enrollment. The esketamine nasal device is dispensed and self-administered by the patient in a monitored treatment area. The supervising clinician documents administration and observes the patient for at least 2 hours post-administration for acute adverse events such as dissociation, sedation, blood pressure elevation, or other safety concerns. Post-observation activities include repeat vital signs, assessment for readiness for discharge, scheduling of follow-up dosing or E/M visit, and documentation of any adverse events and patient instructions. Billing uses HCPCS Level II code G2083 for the established patient visit that includes supervision and observation associated with greater than 56 mg esketamine nasal self-administration and a 2-hour post-administration observation period.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesMay be used for an established patient E/M visit of moderate complexity when billing separate from the esketamine administration visit if payer allows.
    99214Office or other outpatient visit for the evaluation and management of an established patient, typically 25 minutesUsed for higher complexity evaluation and management visits that involve substantial decision making or diagnostic management related to esketamine therapy.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularMay be used in workflows where an injectable adjunct or medication is administered during the visit (check payer bundling rules).
    G2086Office or other outpatient visit for the evaluation and management of a new patient that requires supervision and provision of esketamine nasal self-administration (includes 2 hours post-administration observation)Related HCPCS-level counterpart for new patient visits; used in clinics that differentiate new versus established patient billing.
    99406Smoking and tobacco-use cessation counseling visit, intermediate, greater than 3 minutes up to 10 minutesExample of an ancillary counseling service that may be billed separately if provided during the visit and supported by documentation.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    103K00000X
    2084P0800X
    282N00000X
    363A00000X
    367A00000X
    225XE0001X
    207VC0300X
    163WG0600X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E66.9Obesity, unspecified
    F06.31Mood disorder due to known physiological condition with depressive features
    F10.20Alcohol dependence, uncomplicated
    F11.20Opioid dependence, uncomplicated
    F32.1Major depressive disorder, single episode, moderate
    F32.2Major depressive disorder, single episode, severe without psychotic features
    F32.3Major depressive disorder, single episode, severe with psychotic features
    F32.9Major depressive disorder, single episode, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    F33.2Major depressive disorder, recurrent severe without psychotic features

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    HCPCS-G9490-HOME-ASSESSMENT-NON-HOMEBOUND

    HCPCS G9490: Home Visit Patient Assessment for Non-Homebound Beneficiary

    HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

    HCPCS G0008: Administration of Influenza Virus Vaccine

    HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

    HCPCS G0009: Administration of Pneumococcal Vaccine

    HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

    HCPCS G0010: Administration of Hepatitis B Vaccine

    HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

    HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

    HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

    HCPCS G0012: Injection of PrEP Drug for HIV Prevention

    HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

    HCPCS G0013: Individual PrEP Counseling by Clinical Staff

    HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

    HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

    HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

    HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

    HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

    HCPCS G0019: Community Health Integration, Person-Centered Assessment

    Showing 1–10 of 1996

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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