HCPCS G0434: Drug Screen, Non-Chromatographic, Any Number of Classes

HCPCS Level II code G0434 describes a non-chromatographic drug screen performed in a clinical setting, billed per patient encounter for testing any number of drug classes using a CLIA-waived rapid test or a moderate complexity laboratory test; service type is point-of-care or laboratory drug screening, and the typical site of service is ambulatory clinic, outpatient facility, or clinical laboratory where waived or moderate complexity testing is performed.

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Clinical & Coding Specifications

Clinical Context

A patient presents to an outpatient primary care clinic or urgent care with concerns for possible substance use, medication adherence, or new behavioral symptoms. The clinician performs a point-of-care or clinic-laboratory drug screening using a CLIA-waived immunoassay or a moderate-complexity laboratory test to detect one or more drug classes. Typical indications include monitoring adherence to prescribed controlled substances (e.g., opioids, benzodiazepines), evaluating suspected illicit drug use, pre-procedural screening, or as part of a medication-assisted treatment program for opioid use disorder. The workflow generally includes patient identification and consent, specimen collection (urine, oral fluid, or other acceptable specimen), running the waived or moderate-complexity assay in the clinic or sending it to the in-house moderate-complexity lab, documenting results in the medical record, and incorporating findings into the clinical plan. Billing uses HCPCS Level II code G0434 per patient encounter for any number of drug classes when performed by CLIA-waived or moderate complexity testing in the ambulatory setting.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, leukocytes, nitrite, pH, protein, specific gravity, urobilinogen; non-automated, without microscopy	Often performed alongside a urine drug screen to assess specimen validity and concurrent urinary findings.
`81025`	Urine pregnancy test, by visual color comparison methods	Frequently performed in women of childbearing potential before prescribing certain controlled medications; may be ordered at the same visit.
`80305`	Drug test(s), presumptive, any number of drug classes; non-automated, including instrumented immunoassay when performed	Alternative CPT for clinic-based presumptive drug testing; relates to `G0434` as a lab screening method for multiple drug classes.
`80307`	Drug test(s), definitive, qualitative, each drug or metabolite, chromatographic method, includes specimen preparation and interpretation when performed	Used when a definitive confirmatory test (chromatographic) is required following a positive presumptive screen.
`G0480`	Drug assay, definitive, any number of drug classes, multiple methods, per specimen	Medicare HCPCS code for definitive testing that may be performed after a waived or moderate-complexity screen like `G0434`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
25	CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…	- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
390200000X	Student in an Organized Health Care Education/Training Program	An individual who is enrolled in an organized health care education/training program leading to a degree, certification, registration, and/or licensur…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
103T00000X	Psychologist	A psychologist is an individual who is licensed to practice psychology which is defined as the observation, description, evaluation, interpretation, a…
3336M0002X	Mail Order Pharmacy	A pharmacy where pharmacists compound or dispense prescriptions or other medications in accordance with federal and state law, using common carriers t…
376J00000X	Homemaker	An individual who provides general household activities such as meal preparation, laundry, and light housekeeping, when the individual regularly respo…
207SM0001X	Molecular Genetic Pathology (Medical Genetics) Physician	A board certified subspecialty, the molecular genetic pathologist is expert in the principles, theory and technologies of molecular biology and molecu…

HCPCS G9490: Home Visit Patient Assessment for Non-Homebound Beneficiary

HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

HCPCS G0008: Administration of Influenza Virus Vaccine

HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

HCPCS G0009: Administration of Pneumococcal Vaccine

HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

HCPCS G0010: Administration of Hepatitis B Vaccine

HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

HCPCS G0012: Injection of PrEP Drug for HIV Prevention

HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

HCPCS G0013: Individual PrEP Counseling by Clinical Staff

HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

HCPCS G0019: Community Health Integration, Person-Centered Assessment

Showing 1–10 of 1996

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, leukocytes, nitrite, pH, protein, specific gravity, urobilinogen; non-automated, without microscopy	Often performed alongside a urine drug screen to assess specimen validity and concurrent urinary findings.
`81025`	Urine pregnancy test, by visual color comparison methods	Frequently performed in women of childbearing potential before prescribing certain controlled medications; may be ordered at the same visit.
`80305`	Drug test(s), presumptive, any number of drug classes; non-automated, including instrumented immunoassay when performed	Alternative CPT for clinic-based presumptive drug testing; relates to `G0434` as a lab screening method for multiple drug classes.
`80307`	Drug test(s), definitive, qualitative, each drug or metabolite, chromatographic method, includes specimen preparation and interpretation when performed	Used when a definitive confirmatory test (chromatographic) is required following a positive presumptive screen.
`G0480`	Drug assay, definitive, any number of drug classes, multiple methods, per specimen	Medicare HCPCS code for definitive testing that may be performed after a waived or moderate-complexity screen like `G0434`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
25	CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…	- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
390200000X	Student in an Organized Health Care Education/Training Program	An individual who is enrolled in an organized health care education/training program leading to a degree, certification, registration, and/or licensur…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
103T00000X	Psychologist	A psychologist is an individual who is licensed to practice psychology which is defined as the observation, description, evaluation, interpretation, a…
3336M0002X	Mail Order Pharmacy	A pharmacy where pharmacists compound or dispense prescriptions or other medications in accordance with federal and state law, using common carriers t…
376J00000X	Homemaker	An individual who provides general household activities such as meal preparation, laundry, and light housekeeping, when the individual regularly respo…
207SM0001X	Molecular Genetic Pathology (Medical Genetics) Physician	A board certified subspecialty, the molecular genetic pathologist is expert in the principles, theory and technologies of molecular biology and molecu…

HCPCS G9490: Home Visit Patient Assessment for Non-Homebound Beneficiary

HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

HCPCS G0008: Administration of Influenza Virus Vaccine

HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

HCPCS G0009: Administration of Pneumococcal Vaccine

HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

HCPCS G0010: Administration of Hepatitis B Vaccine

HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

HCPCS G0012: Injection of PrEP Drug for HIV Prevention

HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

HCPCS G0013: Individual PrEP Counseling by Clinical Staff

HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

HCPCS G0019: Community Health Integration, Person-Centered Assessment

Showing 1–10 of 1996

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS G0434: Drug Screen, Non-Chromatographic, Any Number of Classes

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HCPCS G0434: Drug Screen, Non-Chromatographic, Any Number of Classes

Sign up for hcpcs G0434 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

HCPCS G0434: Drug Screen, Non-Chromatographic, Any Number of Classes

Sign up for hcpcs G0434 policy alerts

HCPCS G0434: Drug Screen, Non-Chromatographic, Any Number of Classes

Sign up for hcpcs G0434 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What is the HCPCS Level II code for a non-chromatographic drug screen performed in a clinical setting using a CLIA-waived or moderate complexity test?

What types of drug classes can be tested using HCPCS code `G0434`?

What is the typical site of service for a drug screen billed under HCPCS code `G0434`?

Which related CPT codes might be used in conjunction with HCPCS code `G0434`?

What are some common diagnoses related to drug screening and monitoring?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What is the HCPCS Level II code for a non-chromatographic drug screen performed in a clinical setting using a CLIA-waived or moderate complexity test?

What types of drug classes can be tested using HCPCS code `G0434`?

What is the typical site of service for a drug screen billed under HCPCS code `G0434`?

Which related CPT codes might be used in conjunction with HCPCS code `G0434`?

What are some common diagnoses related to drug screening and monitoring?

References