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    v1.0.30
    OpenPayerBilling CodesDurable Medical EquipmentHCPCS hcpcs-e0500-ippb-machine-nebulization-device
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    HCPCS Level II E0500: Intermittent Positive Pressure Breathing Machine with Nebulizer

    HCPCS Level II code E0500 describes an intermittent positive pressure breathing (IPPB) machine with built-in nebulization, manual or automatic valves, and internal or external power source; service is respiratory therapy device provision for airway clearance and aerosol delivery, and typical site of service is outpatient clinics, hospital respiratory therapy departments, home healthcare, or durable medical equipment settings where therapeutic inhalation and intermittent positive pressure breathing are delivered.

    For related coverage guidance, see recent payer policy updates: Hospital Beds Corporate Medical Policy, Bone Growth Stimulators, Prior Authorization for Durable Medical Equipment (DME).

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A patient with moderate-to-severe obstructive lung disease is prescribed an intermittent positive pressure breathing (IPPB) device with built-in nebulization for short-term inpatient or home use. Typical patients include those with acute exacerbation of chronic obstructive pulmonary disease (COPD), postoperative hypoventilation with retained secretions, or those requiring bronchodilator/nebulized antibiotic delivery with assisted inspiratory support. A common workflow: a respiratory therapist evaluates the patient, documents need for IPPB to improve tidal volumes and aerosol delivery, selects E0500 equipment (portable or bedside unit with internal/external power), instructs patient on mask/mouthpiece use, programs manual or automatic valves, delivers treatment sessions (usually 10–20 minutes, multiple times per day), monitors vitals and oxygenation, records treatment parameters and tolerance, and communicates device plan to the discharging clinician for continuation or discontinuation of therapy. Typical sites of service are inpatient hospital units (medical/surgical, ICU step-down), inpatient rehabilitation, skilled nursing facilities, and home health settings for short-term therapeutic use.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    94640Pressurized or nonpressurized inhalation treatment for acute airway obstruction or for sputum induction for diagnostic purposes (e.g., with IPPB, aerosol generator, nebulizer)Commonly performed during the same session when delivering medicated nebulization via E0500 IPPB device
    94664Demonstration and/or evaluation of patient utilization of an aerosol generator, nebulizer, metered dose inhaler, or IPPB deviceUsed for initial patient instruction and competency assessment when introducing E0500 device
    94002Ventilation assist and management, initiation of pressure or volume preset ventilators for management of acute respiratory failure; hospital inpatient/observation, initial day (less than 24 hours)Related for patients who progress from intermittent IPPB to more advanced ventilatory support; documents escalation of care
    94620Pulmonary function training; initiation of noninvasive positive pressure ventilation (e.g., BiPAP)Related when patients transition between IPPB and other noninvasive modalities; documents training and setup
    94010Pressure support ventilation (continuous) initiation and managementOccasionally billed when IPPB is part of a broader respiratory support plan and monitored over time

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    363A00000X
    2081P0301X
    3418M1110X
    2251H1300X
    175F00000X
    261QE0002X
    2472B0301X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B59Pneumocystosis
    E03.9Hypothyroidism, unspecified
    E11.9Type 2 diabetes mellitus without complications
    E86.0Dehydration
    G31.9Degenerative disease of nervous system, unspecified
    G40.909Epilepsy, unspecified, not intractable, without status epilepticus
    I50.21Acute systolic (congestive) heart failure
    I50.9Heart failure, unspecified
    J12.9Viral pneumonia, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Durable Medical Equipment (DME)1 / 3

    10 rows

    PolicyPayerEffective Date
    Hospital Beds Corporate Medical Policybcbsvermont2027-01-01
    Bone Growth StimulatorsMass General Brigham Health Plan2026-12-01
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-12-01
    Patient Liftsuniverahealthcare2026-11-16
    Medical Car SeatsCareSource2026-11-01
    Non-Invasive Home Mechanical Ventilation (E0466)CareSource2026-11-01
    Digestive Enzyme Cartridgeshusky_health2026-11-01
    Hearing Aids and Assistive Listening Devices for Children Enrolled in Birth-to-Threehusky_health2026-11-01
    Home Non-Invasive Positive Pressure Ventilation (NIPPV) Devices for Respiratory Insufficiency and Failureexcellus_health_plan_inc2026-10-15
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-10-01

    Related Codes

    HCPCS-E0100-CANE-DURABLE-MEDICAL-EQUIPMENT-AMBULATION

    HCPCS E0100: Cane, Adjustable or Fixed, With Tip

    HCPCS-E0105-CANE-QUAD-THREE-PRONG-MOBILITY-AID

    HCPCS Level II E0105: Cane, Quad or Three-Prong, Includes Tips

    HCPCS-E0110-FOREARM-CRUTCHES-PAIR-DME-MOBILITY

    HCPCS Level II E0110: Forearm Crutches, Pair, Complete with Tips and Handgrips

    HCPCS-E0111-CRUTCH-FOREARM-DURABLE-MEDICAL-EQUIPMENT

    HCPCS Level II E0111: Crutch, Forearm, With Tip and Handgrips

    HCPCS-E0112-UNDERARM-WOOD-CRUTCHES-PAIR

    HCPCS Level II E0112: Underarm Wooden Crutches, Pair

    HCPCS-E0113-CRUTCH-UNDERARM-WOOD-ADJUSTABLE-FIXED-WITH-PAD-TIP-HANDGRIP

    HCPCS Level II E0113: Crutch Underarm, Wood, Adjustable or Fixed

    HCPCS-E0114-UNDERARM-CRUTCHES-PAIR-ADJUSTABLE-FIXED

    HCPCS Level II E0114: Underarm (Axillary) Crutches, Adjustable or Fixed, Pair

    HCPCS-E0116-UNDERARM-CRUTCH-NON-WOOD-ADJUSTABLE-FIXED

    HCPCS E0116: Underarm Crutch, Non-Wood, Adjustable/Fixed with Pad

    HCPCS-E0117-ARTICULATING-SPRING-ASSISTED-UNDERARM-CRUTCH

    HCPCS Level II E0117: Crutch, Underarm, Articulating, Spring-Assisted

    HCPCS-E0118-LOWER-LEG-PLATFORM-CRUTCH-SUBSTITUTE

    HCPCS E0118: Crutch Substitute, Lower Leg Platform

    Showing 1–10 of 670

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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