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    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c9250-human-plasma-fibrin-sealant-artiss-2ml
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    HCPCS Level II C9250: Human Plasma Fibrin Sealant (Artiss), 2 ml

    HCPCS Level II code C9250 describes a human plasma fibrin sealant (vapor-heated, solvent-detergent, marketed as Artiss) in a 2 ml vial, used as a surgical topical hemostatic and tissue sealant; the service is the application of the fibrin sealant during surgical procedures, with the typical site of service being the operating room or procedural suite for intraoperative use.

    For related coverage guidance, see recent payer policy updates: Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA), Cardiovascular Disease Risk Assessment, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing a surgical procedure—commonly dermatologic, plastic/reconstructive, head and neck, or orthopedic soft-tissue surgery—where meticulous hemostasis and tissue approximation are required. The product described, C9250 (human plasma fibrin sealant, vapor-heated, solvent-detergent, 2 ml; trade name Artiss), is used intraoperatively as a biologic adhesive and hemostatic adjunct to reduce bleeding, secure skin grafts or flaps, and promote tissue adherence.

    A realistic scenario: A 62-year-old patient presents for Mohs micrographic surgery with a large full-thickness cheek defect that will be reconstructed with a local advancement flap and a split-thickness skin graft. After achieving primary hemostasis with electrocautery and sutures, the surgical team applies C9250 fibrin sealant to the graft bed to enhance graft take and limit postoperative hematoma. Use is performed in the operating room under monitored anesthesia care; nursing documents lot number, expiration, and amount used; the surgeon documents indication, application site, and clinical effect. The product is billed with C9250 and may be appended with appropriate modifiers reflecting service circumstances (for example, modifier 62 for co-surgery or modifier AS for physician assistant when applicable). Typical sites of service include the hospital operating room, ambulatory surgery center, and occasionally office-based procedure rooms for selected dermatologic surgeries.

    Clinical workflow steps:

    • Preoperative: consent includes use of biologic adhesives and discussion of plasma-derived product.

    • Intraoperative: standard hemostasis achieved; C9250 prepared per manufacturer instructions; applied to graft or flap interface; allowed to set for recommended time before dressing and closure.

    • Postoperative: wound assessed for hemostasis and graft adherence; documentation of product and amount used entered into operative report and supply/implant log; charge entry includes C9250 and relevant CPT procedure codes for the surgery and grafting.

    • Billing: billers assign C9250 HCPCS Level II code, add clinically relevant modifiers from payer rules, and link to appropriate ICD-10 diagnosis and CPT procedure codes in the claim.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15271Skin graft, full-thickness; trunk, arms, legs; first 100 sq cm or less, or 1% of body area of infants and childrenOften performed before application of fibrin sealant to secure the graft to the recipient site.
    15275Skin graft, full-thickness; face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, and/or feet; each additional 100 sq cm, or part thereof (List separately in addition to code for primary procedure)Used in complex reconstructive cases that may require fibrin sealant adjunct.
    15734Muscle, myocutaneous, or fasciocutaneous flap; trunkFlap procedures where fibrin sealant is applied to reduce dead space and reinforce tissue adherence.
    12001Repair, simple wounds (e.g., 2.5 cm or less)Minor closures where fibrin sealant may be used adjunctively in the same operative session.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    313M00000XNursing Facility/Intermediate Care FacilityAn institution (or a distinct part of an institution) which- (1) is primarily engaged in providing to residents- (A) skilled nursing care and related …
    2080S0010XPediatric Sports Medicine PhysicianA pediatrician who is responsible for continuous care in the field of sports medicine, not only for the enhancement of health and fitness, but also fo…
    261QH0700XHearing and Speech Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic, treatment, prescriptive, and therapy services related to congenital and acqu…
    208VP0000XPain Medicine PhysicianPain Medicine is a primary medical specialty based on a distinct body of knowledge and a well-defined scope of clinical practice that is founded on sc…

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    6 rows

    PolicyPayerEffective Date
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Cardiovascular Disease Risk Assessmentblue cross blue shield - louisiana2026-09-15
    Cardiovascular Disease Risk AssessmentBlue Cross Blue Shield - New Mexico2026-09-04

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    14060Adjacent tissue transfer or rearrangement, trunk; defect 10 sq cm to 30 sq cmReconstruction codes commonly billed in the same operative episode where C9250 is used to support graft/flap adherence.
    66984Extracapsular cataract removal with insertion of intraocular lens (complex)Example of a separate specialty procedure where fibrin sealant formulations may be used in ophthalmologic surgery for wound sealing (selected when clinically applicable).