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    v1.0.31
    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c7550-cystourethroscopy-biopsy-blue-light-fluorescent-imaging
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    HCPCS C7550: Cystourethroscopy with Biopsy and Blue Light Fluorescence

    HCPCS Level II code C7550 describes a cystourethroscopy with biopsy or biopsies performed using adjunctive blue light cystoscopy with a fluorescent imaging agent; this is an endoscopic diagnostic and interventional urologic procedure typically performed in an operating room, ambulatory surgery center, or procedure suite and involves visualization of the bladder and urethra with targeted tissue sampling under blue light fluorescence to detect and biopsy suspicious lesions.

    For related coverage guidance, see recent payer policy updates: Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation, Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 65-year-old male with a history of non–muscle-invasive bladder cancer who presents for surveillance cystoscopy after prior transurethral resection of bladder tumor (TURBT). During the clinic visit the urologist documents recurrent microscopic hematuria and prior pathology showing papillary urothelial carcinoma. The planned procedure is diagnostic and therapeutic: C7550 (cystourethroscopy with biopsy(ies) with adjunctive blue light cystoscopy using a fluorescent imaging agent) performed in an ambulatory surgical center or hospital outpatient department under monitored anesthesia care or general anesthesia.

    Preoperative workflow includes medication reconciliation, informed consent specific to fluorescent agent administration, allergy assessment (noting any photosensitizer sensitivities), and verification of prior pathology and imaging. Intraoperative steps include instillation of the approved fluorescent imaging agent into the bladder per manufacturer instructions, a dwell time to permit tumor uptake, inspection of the bladder under white light followed by blue light/fluorescent imaging to identify occult lesions, targeted cold-cup or transurethral biopsy of suspicious areas, hemostasis, and specimen submission to pathology. Postoperative workflow includes recovery monitoring for urinary retention or hematuria, discharge instructions, and pathology-driven follow-up planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52000Cystourethroscopy, with or without collection of specimen(s) by brushing or washing, with or without ureteral catheterization; diagnosticBasic diagnostic cystoscopy; C7550 represents an advanced adjunctive service when fluorescent agent and biopsy are performed.
    52204Cystourethroscopy, with biopsy, single or multipleStandard cystoscopic biopsy code; biopsies performed during C7550 correlate clinically with this service though C7550 is an HCPCS Level II code specific to adjunctive blue light fluorescent imaging.
    52214Cystourethroscopy, with transurethral resection of bladder tumor(s), single or multiple, including fulgurationRepresents therapeutic TURBT often performed when lesions identified on blue light cystoscopy require resection beyond biopsy.
    51798Complex cystourethroscopy for implantation of devices or extensive procedures (example code for related complex cystoscopy)Used when more complex endoscopic interventions are performed in conjunction with diagnostic/biopsy work.
    51720Continuous bladder irrigation, including insertion of indwelling bladder irrigation catheter (eg, for gross hematuria)Performed postoperatively when significant hematuria or large-volume irrigation is required after biopsies or TURBT.
    99070Supplies and materials (except for those usually included with the procedure)Billed by facilities when additional supplies related to the fluorescent imaging agent or special equipment are used (payer rules apply).

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    363L00000X
    208000000X
    208800000X
    207L00000X
    207RC0000X
    225XF0002X
    103TM1800X
    1223P0221X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Percutaneous Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillationpremerabluecrossofwashington2027-02-05
    Left Atrial Appendage Occlusion, Closurearkansas_blue_cross_blue_shield2027-02-01
    Percutaneous Left Atrial Appendage Closure - Medical PolicyHealth-New-England2027-02-01
    Transcatheter Mitral Valve Repair Medical PolicyHealth-New-England2027-02-01
    Cardiac Electrophysiological (EP) Studies and Cardiac Ablation of Abnormal Electrical RhythmsCigna2027-01-15
    IvabradineCigna2026-11-15
    Tilt Table TestingCigna2026-11-15
    Cardiac Contractility Modulation for Heart FailureProvidence Health Plan2026-11-01

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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