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    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c2645-brachytherapy-palladium-103-planar-source-per-mm2
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    HCPCS Level II C2645: Brachytherapy Planar Source, Palladium-103

    HCPCS Level II code C2645 describes a brachytherapy planar source containing palladium-103 charged per square millimeter, used for implantable radiation therapy delivery; the service is a brachytherapy source supply typically used in radiation oncology settings such as hospital outpatient departments or specialized cancer treatment centers where planar seeds are prepared and supplied for interstitial or surface brachytherapy procedures.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with clinically localized prostate cancer undergoes permanent seed brachytherapy using palladium-103 sources. The radiation oncology team orders C2645 billed per square millimeter for the planar palladium-103 sources used to create low-dose-rate implants placed intraoperatively under ultrasound guidance. Typical workflow: pre-procedure consultation and staging (history, prostate MRI, prostate biopsy pathology), treatment planning by a medical physicist with dosimetry and source ordering, operating-room or procedure-suite transperineal implantation using transrectal ultrasound guidance, intraoperative real-time dosimetry adjustments, and post-implant dosimetric verification with CT within 30 days. Typical site of service is an outpatient hospital-based procedure room, ambulatory surgery center, or radiation oncology department procedural suite. Common clinical indications include localized prostate adenocarcinoma and select small-volume recurrent pelvic soft-tissue malignancies where palladium-103 LDR planar sources are clinically appropriate.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    55873Brachytherapy, interstitial radiation source application, perineal template, prostate; placement of needles or catheters and intraoperative dosimetry, includes imaging guidanceOften used for the placement portion of prostate seed implants and intraoperative dosimetry planning when performed alongside source supply billed with C2645
    55874Brachytherapy, interstitial radiation source application, prostate, including placement and transperineal template, includes imaging and dosimetry (separate code for complex or additional techniques)Used for comprehensive brachytherapy implantation services that may accompany source utilization
    77316Brachytherapy dosimetry (for radiation physics)Used for post-implant dose calculations and verification of seed placement and dosimetry when palladium-103 sources are implanted
    76937Ultrasound guidance for needle placement (e.g., prostate)Used during transrectal ultrasound-guided implantation to localize and guide source placement
    57454Colposcopy with loop electrode biopsy (not directly related to prostate but example of gynecologic brachytherapy imaging procedures)Not typical for prostate implants; included only when gynecologic planar palladium-103 brachytherapy is performed in select soft-tissue sites
    A4649Radiopharmaceutical, non-therapeutic, not otherwise classified (example supply code)Facility supply billing codes for radionuclide sources may be billed alongside C2645 depending on payor rules

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    363LF0000XFamily Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    367500000XCertified Registered Nurse Anesthetist(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
    122400000XDenturistA denturist is a licensed professional that serves patients with removable dental prosthetic oral health needs. A licensed denturist is trained in rem…
    364SI0800XInformatics Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    261QM1200XMagnetic Resonance Imaging (MRI) Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    207ZC0008XClinical Informatics (Pathology) PhysicianPhysicians who practice Clinical Informatics collaborate with other health care and information technology professionals to analyze, design, implement…
    1041S0200XSchool Social WorkerBehavioral Health & Social Service Providers · Social Worker
    2084B0040XBehavioral Neurology & Neuropsychiatry PhysicianBehavioral Neurology & Neuropsychiatry is a medical subspecialty involving the diagnosis and treatment of neurologically based behavioral issues.

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    C00.9Malignant neoplasm of lip, unspecified
    C16.9Malignant neoplasm of stomach, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C22.0Liver cell carcinoma
    C44.90Unspecified malignant neoplasm of skin, unspecified
    C44.91Basal cell carcinoma of skin, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C50.912Malignant neoplasm of unspecified site of left female breast
    C50.919Malignant neoplasm of unspecified site of unspecified female breast

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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