Summary & Overview
HCPCS B4105: In-line Digestive Enzyme Cartridge for Enteral Feeding
HCPCS Level II code B4105 represents an in-line cartridge containing digestive enzyme(s) intended for use with enteral feeding systems. The code identifies a discrete medical supply component that can affect nutrition management for patients requiring tube-based enteral nutrition. Nationally, clear coding for enteral feeding accessories matters for clinical continuity, claims accuracy, and appropriate payment for durable medical equipment and related supplies.
Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context for enzyme cartridges in enteral nutrition, common payer coverage landscapes, and guidance on where to find reimbursement benchmarks and policy updates. The publication outlines typical sites of service (home care, inpatient hospital, long-term care) and the service type (medical supply accessory for enteral nutrition administration). Where available, comparative benchmarks, coding guidance nuances, and recent policy developments affecting HCPCS Level II supply codes are summarized. Data not available in the input is noted where applicable.
Billing Code Overview
HCPCS Level II code B4105 describes an in-line cartridge containing digestive enzyme(s) for enteral feeding, each. This item is a single-use or replaceable cartridge designed to deliver digestive enzymes directly into an enteral feeding system to aid nutrient digestion for patients receiving tube feeding.
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Service type: Medical supply accessory for enteral nutrition administration
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Typical site of service: Home, inpatient hospital, long-term care, or other settings where enteral tube feeding is provided
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult or pediatric patient receiving long-term or short-term enteral tube feeding who requires supplemental digestive enzymes to aid digestion and absorption due to exocrine pancreatic insufficiency, post-pancreatectomy state, or poor tolerance of enteral formula. The in-line enzyme B4105 is dispensed as a cartridge placed into the feeding set or enteral pump cartridge system and delivers digestive enzymes directly into the enteral feeding line during continuous or bolus tube feeds.
A common clinical workflow: a gastroenterology or nutrition support clinician documents the indication (for example, malabsorption due to pancreatic insufficiency). An enteral nutrition order is written specifying the need for in-line enteral enzymes. Pharmacy or a home infusion/enteral supplier dispenses the B4105 cartridge. At bedside or in the home, nursing or trained caregivers attach the cartridge to the feeding tubing per manufacturer instructions, confirm pump settings for feed rate, monitor tolerance (abdominal pain, bloating, stool output), and document use in the medical record. Reorders occur based on ongoing clinical need and payer authorizations.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier |