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    v1.0.28
    OpenPayerBilling CodesAdministrative, Miscellaneous and InvestigationalHCPCS hcpcs-a9564-chromic-phosphate-p-32-therapeutic-suspension-per-millicurie
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    HCPCS Level II A9564: Chromic Phosphate P-32 Therapeutic Suspension

    HCPCS Level II code A9564 describes a therapeutic radiopharmaceutical — chromic phosphate P-32 suspension — billed per millicurie for intralesional or intracavitary radiation therapy; the service is a therapeutic nuclear medicine procedure typically administered in a hospital outpatient department, radiation oncology clinic, or specialty infusion/therapy center for localized treatment of malignant or benign effusions or lesions.

    For related coverage guidance, see recent payer policy updates: Interferential Stimulation Devices (for home use), Durable Medical Equipment (DME): Tumor Treating Fields (Alternating Electric Field Therapy) Medical Guideline, Durable Medical Equipment (DME): Bone Growth Stimulators Medical Guideline.

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    Table of contents

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    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
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    • PayersPlans & market footprint
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    • ModifiersCPT modifiers & usage
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    • Coverage CriteriaMedical necessity by payer
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    Clinical & Coding Specifications

    Clinical Context

    A patient with refractory localized or diffuse synovitis, malignant pleural effusion, or certain hematologic malignancies is referred to an interventional oncology or nuclear medicine service for intralesional or intrapleural radiopharmaceutical therapy. The clinician prescribes A9564 (chromic phosphate P-32 suspension) measured in millicuries based on disease extent and prior treatments. Typical workflow: the patient is evaluated in outpatient oncology or hospital oncology clinic; informed consent and radiation safety counseling are completed; baseline labs and imaging (e.g., ultrasound, CT) are reviewed; a radiation safety officer verifies activity and prepares the P-32 dose in a licensed radiopharmacy; the patient is brought to a procedure room or nuclear medicine suite; under image guidance or direct instillation, the clinician administers the P-32 suspension into the target cavity (for example, the pleural space) or lesion; post-procedure monitoring is performed for immediate complications; discharge instructions include radiation precautions and follow-up imaging to assess response. Typical site of service: hospital outpatient department, inpatient hospital bed (for hospitalized patients), or specialized nuclear medicine/interventional oncology clinic. Typical patient scenario: a 68-year-old with recurrent malignant pleural effusion from metastatic lung adenocarcinoma undergoes thoracoscopic drainage and intrapleural instillation of A9564 to reduce recurrent effusion and palliative symptoms.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    32554Thoracentesis, therapeutic (eg, for pleural effusion) requiring insertion of indwelling catheterOften performed prior to or in conjunction with intrapleural P-32 instillation to drain effusion and allow cavity-directed therapy
    32557Tube thoracostomy, includes drainage by indwelling catheter, with connection to drainage systemMay be used when chest tube placement is required for access or ongoing drainage before P-32 administration
    32662Thoracoscopy, diagnostic and therapeutic; with drainage and/or biopsy including insertion of instrumentationUsed when thoracoscopic access is required to instill intrapleural radiopharmaceuticals under direct visualization
    96440Chemotherapy administration into pleural cavity, intrapleural, requiring image guidance, initial; non-hormonal, antineoplastic agentRepresents intrapleural administration technique and may be reported when applicable for similar administration services; documents the administration component related to P-32 therapy
    76942Ultrasonic guidance for needle placement (eg, biopsy, aspiration, injection), imaging supervision and interpretation

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RR0500XRheumatology PhysicianAn internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    332H00000XEyewear SupplierAn organization that provides spectacles, contact lenses, and other vision enhancement devices prescribed by an optometrist or ophthalmologist.
    101YP2500XProfessional CounselorBehavioral Health & Social Service Providers · Counselor
    273R00000XPsychiatric Hospital UnitIn general, a distinct unit of a hospital that provides acute or long-term care to emotionally disturbed patients, including patients admitted for dia…
    242T00000XPerfusionistA perfusionist operates extracorporeal circulation and autotransfusion equipment during any medical situation where it is necessary to support or temp…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C71.0Malignant neoplasm of cerebrum, except lobes and ventricles
    C71.1Malignant neoplasm of frontal lobe
    C71.2Malignant neoplasm of temporal lobe
    C71.9Malignant neoplasm of brain, unspecified
    C72.0Malignant neoplasm of spinal cord
    C79.31Secondary malignant neoplasm of brain
    C79.32Secondary malignant neoplasm of cerebral meninges
    D18.1Lymphangioma, any site
    D33.0Benign neoplasm of brain, supratentorial
    D33.1Benign neoplasm of brain, infratentorial

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Durable Medical Equipment (DME)1 / 3

    5 rows

    PolicyPayerEffective Date
    Interferential Stimulation Devices (for home use)Moda Health2026-10-01
    Durable Medical Equipment (DME): Tumor Treating Fields (Alternating Electric Field Therapy) Medical GuidelineWPS Health Insurance2026-10-01
    Durable Medical Equipment (DME): Bone Growth Stimulators Medical GuidelineWPS Health Insurance2026-10-01
    General Durable Medical Equipment (DME) Medical GuidelineWPS Health Insurance2026-10-01
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-10-01

    Related Codes

    HCPCS-A9150-NON-PRESCRIPTION-DRUGS

    HCPCS Level II A9150: Non-prescription Drugs

    HCPCS-A9152-SINGLE-ORAL-VITAMIN-MINERAL-DOSE

    HCPCS A9152: Single Oral Vitamin/Mineral/Trace Element

    HCPCS-A9153-MULTIVITAMIN-ORAL-PER-DOSE

    HCPCS A9153: Multiple Vitamins, Oral, Per Dose

    HCPCS-A9154-ARTIFICIAL-SALIVA-1ML

    HCPCS Level II A9154: Artificial saliva, 1 ml

    HCPCS-A9155-ARTIFICIAL-SALIVA-30ML

    HCPCS Level II A9155: Artificial Saliva, 30 mL

    HCPCS-A9156-ORAL-MUCOADHESIVE-PER-1ML

    HCPCS Level II A9156: Oral Mucoadhesive, Per 1 ml

    HCPCS-A9180-PEDICULOSIS-TOPICAL-TREATMENT-PATIENT-ADMINISTRATION

    HCPCS Level II A9180: Pediculosis Topical Treatment for Patient/Caretaker

    HCPCS-A9268-PROGRAMMER-TRANSIENT-INGESTED-CAPSULE

    HCPCS Level II A9268: Programmer for Transient Orally Ingested Capsule

    HCPCS-A9269-PROGRAMMABLE-TRANSIENT-ORAL-CAPSULE

    HCPCS Level II A9269: Programmable Orally Ingested Capsule, Per Month

    HCPCS-A9270-NON-COVERED-ITEM-OR-SERVICE

    HCPCS A9270: Non-covered Item or Service

    Showing 1–10 of 138

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Commonly reported when ultrasound guidance is used to place a catheter or needle prior to instillation of radiopharmaceuticals