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    v1.0.30
    OpenPayerBilling CodesAdministrative, Miscellaneous and InvestigationalHCPCS hcpcs-a9527-iodine-i125-therapeutic-solution-per-millicurie
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    HCPCS A9527: Iodine I-125 Sodium Iodide Therapeutic Solution per mCi

    HCPCS Level II code A9527 describes therapeutic sodium iodide I-125 in solution billed per millicurie, used for radiotherapeutic treatment involving administration of I-125 for targeted radioactive therapy; typical service type is radiopharmaceutical therapy and the usual site of service is hospital outpatient departments or specialized nuclear medicine facilities where radioactive therapeutic doses are prepared and administered.

    For related coverage guidance, see recent payer policy updates: Hospital Beds Corporate Medical Policy, Continuous Passive Motion Devices with Remote Monitoring or Adaptive Capabilities, Bone Growth Stimulators.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with differentiated thyroid carcinoma is evaluated for adjuvant radioiodine therapy. The oncology and nuclear medicine teams determine therapeutic dosing of radioactive iodine I-125 (sodium iodide) to treat residual thyroid tissue or metastatic disease. The patient presents to an outpatient nuclear medicine or hospital-based radiation therapy suite after appropriate pre-procedure preparation, which includes thyroid hormone withdrawal or recombinant human TSH stimulation, pregnancy testing for women of childbearing potential, informed consent, and baseline labs and imaging (thyroid ultrasound, diagnostic whole-body scan or PET/CT as indicated).

    On the day of service the nuclear medicine physician documents the prescribed activity in millicuries, verifies patient identity and pregnancy status, prepares and dispenses A9527 (iodine I-125 sodium iodide solution, therapeutic, per millicurie) using calibrated dose preparation procedures in a licensed radiopharmacy or authorized nuclear medicine department, and administers the oral solution or capsule. Post-administration instructions include radiation safety precautions, substance handling, and schedule for follow-up imaging or thyroglobulin monitoring. Typical sites of service are outpatient hospital radiology/nuclear medicine departments, freestanding radiopharmacies for dispensing, and inpatient hospital units when inpatient therapy is required.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78800Radiopharmaceutical therapy administration; unsealed radiopharmaceutical, therapeutic, per single administrationFrequently billed for the administration procedure when a therapeutic radiopharmaceutical dose such as A9527 is given orally or intravenously
    78120Radioactive iodine uptake, diagnosticPerformed before or after therapy to assess iodine uptake and guide therapeutic dosing decisions
    79005Radiopharmaceutical localization of tumor or distribution of radiopharmaceutical agent, single study; this code group includes imaging procedures related to therapeutic agentsUsed for diagnostic whole-body or targeted imaging studies associated with planning or post-therapy assessment
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesUsed for pre-procedure evaluation, informed consent, and routine follow-up counseling related to therapy
    99070Supplies and materials (e.g., wipes, dressings), used during the procedure, when not included in the serviceMay be used to report additional non-covered supply costs associated with preparation or administration of the radiopharmaceutical

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    174400000X
    363L00000X
    363A00000X
    207RC0001X
    335G00000X
    172A00000X
    246YC3302X
    207T00000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C73Malignant neoplasm of thyroid gland
    C74.91Malignant neoplasm of unspecified part of right adrenal gland
    C75.1Malignant neoplasm of pituitary gland
    D34Benign neoplasm of thyroid gland
    D44.2Neoplasm of uncertain behavior of parathyroid gland
    E01.0Iodine-deficiency related diffuse (endemic) goiter
    E01.1Iodine-deficiency related multinodular (endemic) goiter
    E02Subclinical iodine-deficiency hypothyroidism
    E03.9Hypothyroidism, unspecified
    E04.9Nontoxic goiter, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Durable Medical Equipment (DME)1 / 3

    10 rows

    PolicyPayerEffective Date
    Hospital Beds Corporate Medical Policybcbsvermont2027-01-01
    Continuous Passive Motion Devices with Remote Monitoring or Adaptive CapabilitiesBlue Cross Blue Shield - Rhode Island2026-12-01
    Bone Growth StimulatorsMass General Brigham Health Plan2026-12-01
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-12-01
    Patient Liftsuniverahealthcare2026-11-16
    Medical Car SeatsCareSource2026-11-01
    Non-Invasive Home Mechanical Ventilation (E0466)CareSource2026-11-01
    Digestive Enzyme Cartridgeshusky_health2026-11-01
    Hearing Aids and Assistive Listening Devices for Children Enrolled in Birth-to-Threehusky_health2026-11-01
    Home Non-Invasive Positive Pressure Ventilation (NIPPV) Devices for Respiratory Insufficiency and Failureexcellus_health_plan_inc2026-10-15

    Related Codes

    HCPCS-A9150-NON-PRESCRIPTION-DRUGS

    HCPCS Level II A9150: Non-prescription Drugs

    HCPCS-A9152-SINGLE-ORAL-VITAMIN-MINERAL-DOSE

    HCPCS A9152: Single Oral Vitamin/Mineral/Trace Element

    HCPCS-A9153-MULTIVITAMIN-ORAL-PER-DOSE

    HCPCS A9153: Multiple Vitamins, Oral, Per Dose

    HCPCS-A9154-ARTIFICIAL-SALIVA-1ML

    HCPCS Level II A9154: Artificial saliva, 1 ml

    HCPCS-A9155-ARTIFICIAL-SALIVA-30ML

    HCPCS Level II A9155: Artificial Saliva, 30 mL

    HCPCS-A9156-ORAL-MUCOADHESIVE-PER-1ML

    HCPCS Level II A9156: Oral Mucoadhesive, Per 1 ml

    HCPCS-A9180-PEDICULOSIS-TOPICAL-TREATMENT-PATIENT-ADMINISTRATION

    HCPCS Level II A9180: Pediculosis Topical Treatment for Patient/Caretaker

    HCPCS-A9268-PROGRAMMER-TRANSIENT-INGESTED-CAPSULE

    HCPCS Level II A9268: Programmer for Transient Orally Ingested Capsule

    HCPCS-A9269-PROGRAMMABLE-TRANSIENT-ORAL-CAPSULE

    HCPCS Level II A9269: Programmable Orally Ingested Capsule, Per Month

    HCPCS-A9270-NON-COVERED-ITEM-OR-SERVICE

    HCPCS A9270: Non-covered Item or Service

    Showing 1–10 of 138

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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