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    v1.0.28
    OpenPayerBilling CodesSkin Substitute DeviceHCPCS hcpcs-a4100-non-sheet-skin-substitute-fda-device
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    HCPCS Level II A4100: Non-sheet Skin Substitute, FDA-cleared Device

    Medicare pays $133 on average nationally for this procedure.

    HCPCS Level II code A4100 describes a non-sheet form skin substitute that is FDA-cleared as a device and billed in addition to the primary procedure; the service represents application or placement of a biologic or synthetic skin substitute product used to treat wounds or defects, typically provided in operative or procedural settings such as operating rooms or procedural treatment suites.

    For related coverage guidance, see recent payer policy updates: Reduction Mammoplasty (Breast Reduction Surgery) for Symptomatic Macromastia, Gynecomastia Surgery, Panniculectomy (Abdominal skin/fat surgery).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with a chronic, non-healing lower extremity wound following peripheral vascular disease and prior debridement presents to an outpatient wound care clinic for advanced reconstruction. The clinician evaluates the wound, performs sharp debridement of devitalized tissue, achieves hemostasis, and selects a non-sheet form skin substitute cleared by the FDA as a device to promote granulation and closure. The substitute is applied directly to the prepared wound bed, secured per product instructions, and covered with appropriate dressings. The patient is instructed on offloading, follow-up frequency, and signs of infection. Subsequent visits assess graft take, replace dressings, and may repeat applications of the non-sheet form skin substitute as clinically indicated. Typical multidisciplinary workflow includes the referring vascular surgeon or primary care physician, the wound care specialist (podiatrist, general surgeon, or plastic surgeon), nursing staff for dressing changes, and periodic vascular evaluation if ischemia persists. Typical documentation includes wound measurements, base and exudate description, debridement performed, device lot and manufacturer, application technique, and informed consent for use of an FDA-cleared device.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue (includes epidermis and dermis) first 20 sq cm or lessOften performed immediately prior to application of a non-sheet skin substitute to prepare the wound bed
    11043Debridement, muscle and/or fascia (includes epidermis and dermis) first 20 sq cm or lessUsed when deeper debridement is required before device application for infected or necrotic wounds
    15271Application of a skin substitute graft to trunk, arms, legs; first 100 sq cm or lessCPT for application of a bi-layer or single application skin substitute; used when reporting the product application alongside device HCPCS
    97597Debridement (eg, high pressure or sharp) of open wound, non-selective, including topical application(s), wound assessment, and instruction; initial 20 sq cm or lessOften used for non-surgical debridement and wound care visits accompanying device application
    13131Secondary closure of surgical wound (eg, scar revision) trunk, arms, legs; simpleMay be performed in later stages if closure or revision is required after achieving granulation with the skin substitute

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    261QE0800XEndoscopy Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    273Y00000XRehabilitation Hospital UnitIn general, a distinct unit of a general acute care hospital that provides care encompassing a comprehensive array of restoration services for the dis…
    347D00000XTrainAn organization or business licensed to provide passenger train service, including light rail, subway, and traditional services.

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 2

    8 rows

    PolicyPayerEffective Date
    Reduction Mammoplasty (Breast Reduction Surgery) for Symptomatic MacromastiaWPS Health Insurance2026-10-01
    Gynecomastia SurgeryCigna2026-08-15
    Panniculectomy (Abdominal skin/fat surgery)moda_health_plan_inc2026-08-13
    Cosmetic and Reconstructive Procedures (for Tennessee Only)UnitedHealthcare2026-08-01
    Breast Reduction Surgery (for Idaho Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Procedures (for Ohio Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Procedures (for Kentucky Only)UnitedHealthcare2026-08-01
    Panniculectomy Surgery (for Kansas Only)UnitedHealthcare2026-08-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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