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    v1.0.28
    OpenPayerBilling CodesMatrix for Wound Management (Placental, Equine, Synthetic)HCPCS hcpcs-a2028-micromatrix-flex-per-mg
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    HCPCS Level II A2028: Micromatrix flex, per mg

    HCPCS Level II code A2028 describes billing for Micromatrix flex, per mg, a medication formulation billed by weight for use in clinical settings; the service type is pharmaceutical administration / drug supply, and the typical site of service is hospital outpatient, clinic, or infusion center where the product is prepared and administered to a patient.

    For related coverage guidance, see recent payer policy updates: Gynecomastia Surgery, Panniculectomy (Abdominal skin/fat surgery), Breast Reduction Surgery (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing treatment requiring a micromatrix flexible dermal or implantable biomaterial provided and billed by weight using HCPCS Level II code A2028 (Micromatrix flex, per mg). The scenario often occurs in outpatient specialty clinics (e.g., dermatology, plastic surgery, wound care) or ambulatory surgical centers where soft tissue reconstruction, dermal augmentation, grafting for chronic wounds, or reconstructive procedures are performed. Clinical workflow: the patient presents with a defect, chronic non-healing wound, or soft-tissue deficiency. The clinician evaluates the defect, documents indication and size, obtains informed consent, prepares the micromatrix product in the sterile field, measures and records the milligram quantity used, and applies or implants the product during the procedure. Billing uses A2028 with the actual milligram amount; clinical documentation must link the product quantity to the procedure note and underlying diagnosis. Typical sites of service include outpatient clinic procedure rooms, ambulatory surgery centers, and hospital outpatient departments. Common patient comorbidities include diabetes mellitus, peripheral vascular disease, prior radiation to the area, or traumatic soft-tissue loss.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    12001Simple repair of superficial wounds of scalp, neck, axillae, external genitalia, trunk and/or extremities; 2.5 cm or lessMay be used for simple closure performed before or after micromatrix placement for small wound margins.
    13131Repair, complex, trunk; 1.1 cm to 2.5 cmUsed when complex layered closure or reconstruction accompanies micromatrix implantation for larger defects.
    15002Tissue grafts, free (includes obtaining graft); first 20 sq cm or less, full-thickness graftUsed when autologous grafting is performed in conjunction with or as an alternative to micromatrix products.
    15271Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or lessDirectly related when a biologic or synthetic skin substitute (matrix) is applied; often reported alongside product billing.
    97597Debridement (e.g., high-pressure waterjet, sharp debridement, enzymatic, autolytic), initial; total wound(s) surface area up to 20 sq cmFrequently performed prior to micromatrix placement to prepare wound bed and enable integration.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    208100000XPhysical Medicine & Rehabilitation PhysicianPhysical medicine and rehabilitation, also referred to as rehabilitation medicine, is the medical specialty concerned with diagnosing, evaluating, and…
    2080P0206XPediatric Gastroenterology PhysicianA pediatrician who specializes in the diagnosis and treatment of diseases of the digestive systems of infants, children and adolescents. This speciali…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    163WL0100XLactation Consultant (Registered Nurse)Nursing Service Providers · Registered Nurse
    163WP2201XAmbulatory Care Registered NurseNursing Service Providers · Registered Nurse
    1223E0200XEndodonticsThe branch of dentistry that is concerned with the morphology, physiology and pathology of the human dental pulp and periradicular tissues. Its study…
    207LP2900XPain Medicine (Anesthesiology) PhysicianAn anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Gynecomastia SurgeryCigna2026-08-15
    Panniculectomy (Abdominal skin/fat surgery)moda_health_plan_inc2026-08-13
    Breast Reduction Surgery (for Idaho Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Procedures (for Tennessee Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Procedures (for Ohio Only)UnitedHealthcare2026-08-01
    Panniculectomy Surgery (for Kansas Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Procedures (for Kentucky Only)UnitedHealthcare2026-08-01
    Panniculectomy Surgery (for Tennessee Only)UnitedHealthcare2026-08-01
    Cosmetic and Reconstructive Surgery Procedurespriority health2026-08-01
    Breast Reduction Surgery (for Ohio Only)Colorado Rocky Mountain Health Plans2026-08-01

    Related Codes

    HCPCS-A2001-INNOVAMATRIX-PER-SQ-CM

    HCPCS Level II A2001: Innovamatrix ac, per square centimeter (add-on)

    HCPCS-A2002-MIRRAGEN-ADVANCED-WOUND-MATRIX-PER-CM2

    HCPCS Level II A2002: Mirragen Advanced Wound Matrix, per sq cm

    HCPCS-A2004-XCELLISTEM-1MG-SPECIALTY-BIOLOGIC-SUPPLY

    HCPCS A2004: Xcellistem, 1 mg

    HCPCS-A2005-MICROLYTE-MATRIX-WOUND-BIOMATERIAL-PER-CM2

    HCPCS Level II A2005: Microlyte Matrix, Per Square Centimeter

    HCPCS-A2006-NOVOSORB-DERMAL-MATRIX-PER-CM

    HCPCS A2006: Novosorb Synpath Dermal Matrix, per cm2

    HCPCS-A2007-RESTRATA-PER-SQ-CM-TOPICAL-WOUND-MATERIAL

    HCPCS Level II A2007: Restrata, per Square Centimeter (Add-on)

    HCPCS-A2008-THERAGENESIS-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2008: Theragenesis, Per Square Centimeter

    HCPCS-A2009-SYMPHONY-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2009: Symphony, per Square Centimeter (Add-on)

    HCPCS-A2010-APIS-PER-SQUARE-CENTIMETER-TOPICAL-BIOLOGIC-ADD-ON

    HCPCS Level II A2010: Apis Topical Product Per Square Centimeter

    HCPCS-A2011-SUPRA-SDRM-PER-SQ-CM-ADD-ON

    HCPCS Level II A2011: Suprasdrm per Square Centimeter (Add-on)

    Showing 1–10 of 43

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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