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    OpenPayerBilling CodesTherapeutic, Prophylactic, and Diagnostic Injections and Infusions (Excludes Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration)CPT cpt-96379-unspecified-intravenous-intraarterial-injection-infusion
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    CPT 96379: Unlisted IV/IA Therapeutic, Prophylactic, or Diagnostic Injection/Infusion

    CPT code 96379 reports an unlisted therapeutic, prophylactic, or diagnostic intravenous or intraarterial injection or infusion procedure performed when no specific CPT code describes the service; the service type is an intravenous or intraarterial injection/infusion and the typical site of service is any clinical setting where IV/IA injections or infusions are delivered (outpatient clinic, hospital, or physician office).

    For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver Disease.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult receiving an unlisted therapeutic intravenous infusion when no specific CPT code exists for the drug, route, or clinical scenario. Example: a 58-year-old patient with refractory autoimmune disease admitted to an outpatient infusion center for a specialty biologic administered intravenously that does not map to an existing infusion code. The clinical workflow: order placed by the treating physician, medication prepared by pharmacy, vascular access established (peripheral IV or existing central line), infusion administered under nursing supervision, patient monitored for infusion reactions, documentation of drug name, dose, route, start/stop times, and any complications. Billing uses 96379 when the infusion/injection is therapeutic, prophylactic, or diagnostic and no specific CPT code applies; an appropriate modifier may be appended to report unusual circumstances (for example, modifier 22 for increased procedural services or modifier 52 for reduced services).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourUsed when the infusion can be reported with a specific initial infusion code instead of 96379 for standard-duration infusions.
    96366Intravenous infusion; each additional hour (List separately in addition to code for primary infusion)Used to report additional time-based infusion units when infusion duration extends beyond the initial hour.
    96413Chemotherapy administration, intravenous infusion technique; each additional hourRelevant when chemotherapy agents are infused and a chemotherapy-specific code is applicable rather than 96379.
    96374Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intravenous push, single or initial substance/drugUsed when the medication is administered as an IV push with a specific injection code available instead of 96379.
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderPerformed before infusion when central venous access is required for administration of complex or high-risk infusates.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    3416L0300XLand AmbulanceTransportation Services · Ambulance
    146M00000XIntermediate Emergency Medical TechnicianAn Intermediate EMT is an individual trained and certified to perform intermediate life support treatment in medical emergencies based on individual s…
    163WW0101XAmbulatory Women's Health Care Registered NurseNursing Service Providers · Registered Nurse
    224900000XMastectomy FitterAn individual trained in the fitting and adjusting of breast prostheses and management of post-mastectomy prostheses services.

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.912Malignant neoplasm of unspecified site of left female breast
    C71.9Malignant neoplasm of brain, unspecified
    D50.9Iron deficiency anemia, unspecified
    D63.1Anemia in chronic kidney disease
    D65Disseminated intravascular coagulation [defibrination syndrome]
    E11.9Type 2 diabetes mellitus without complications
    E86.0Dehydration

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01
    Celiac Disease TestingOscar Health2026-10-01
    Laboratory Testing for the Diagnosis of Inflammatory Bowel DiseaseOscar Health2026-10-01
    Percutaneous Electrical Nerve Field Stimulation (PENFS)Cigna2026-09-15
    Colorectal Cancer ScreeningBlue Cross Blue Shield - New Mexico2026-09-04

    Related Codes

    CPT-96365-INITIAL-INTRAVENOUS-INFUSION-UP-TO-1-HOUR

    CPT 96365: Initial Intravenous Infusion, Up to 1 Hour

    CPT-96366-ADDITIONAL-HOUR-INTRAVENOUS-INFUSION

    CPT 96366: Additional Hour Intravenous Infusion

    CPT-96367-ADDITIONAL-INTRAVENOUS-INFUSION-DIFFERENT-SUBSTANCE-UP-TO-1-HOUR

    CPT 96367: Additional IV Infusion of Different Medication, Up to 1 Hour

    CPT-96368-CONCURRENT-INTRAVENOUS-INFUSION-MULTIPLE-MEDICATIONS

    CPT 96368: Concurrent Intravenous Infusion of Multiple Medications

    CPT-96369-SUBCUTANEOUS-INFUSION-SETUP-AND-ADMINISTRATION-UP-TO-1-HOUR

    CPT 96369: Infusion Pump Setup with Subcutaneous Port, Up to 1 Hour

    CPT-96370-SUBCUTANEOUS-INFUSION-ADDITIONAL-HOUR

    CPT 96370: Subcutaneous Infusion Per Additional Hour

    CPT-96371-SUBCUTANEOUS-PORT-SITE-ESTABLISHMENT-AND-INFUSION-PUMP-SETUP

    CPT 96371: Subcutaneous Port Relocation with Infusion Pump Administration

    CPT-96372-SUBCUTANEOUS-INTRAMUSCULAR-INJECTION-THERAPEUTIC-PROPHYLACTIC-DIAGNOSTIC

    CPT 96372: Intramuscular or Subcutaneous Therapeutic Injection

    CPT-96373-ARTERIAL-MEDICATION-ADMINISTRATION

    CPT 96373: Intra-arterial Medication Administration

    CPT-96374-INTRAVENOUS-PUSH-SINGLE-MEDICATION

    CPT 96374: Rapid Intravenous Push Medication Administration

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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