CPT code 95921 represents evaluation of autonomic nervous system function using ECG rhythm strips to record heart rate and rhythm responses to provocation maneuvers such as deep breathing, the Valsalva maneuver, and standing. This physiologic testing helps clinicians identify abnormalities in involuntary cardiovascular control that can underlie syncope, orthostatic intolerance, neuropathies, and other disorders. Nationally, such testing informs diagnosis and management of autonomic disorders and impacts utilization in neurology and cardiology outpatient settings.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical description, typical sites of service, and the common modifiers associated with reporting the service. The publication also provides context on clinical indications and expected documentation elements. Where available, benchmarking and payer coverage notes summarize how major commercial payers and Medicare commonly approach authorization and reimbursement for autonomic function testing. Data not available in the input is noted where specific payer policies or procedural volumes would normally be provided.