CPT code 95130 represents in-office administration of stinging insect venom for a single insect species to treat or prevent allergic reactions in sensitized patients. Nationwide, venom immunotherapy is a clinically important intervention for patients at risk of systemic reactions to insect stings; accurate coding supports appropriate clinical documentation and payer adjudication. Key national payers include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise overview of the clinical purpose of 95130, the typical ambulatory setting for this service, and which major payers commonly cover venom immunotherapy administration. The publication summarizes coding context, common modifiers used with this service, and provides national benchmarking and policy context where available. It also outlines clinical implications for allergists and other office-based providers who deliver venom immunotherapy and highlights documentation elements that influence medical necessity determinations. Data not available in the input is noted where applicable, and the focus remains on national coverage and coding considerations rather than state-specific rules.