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    v1.0.30
    OpenPayerBilling CodesFlow Cytometry ProceduresCPT cpt-88182-flow-cytometry-cell-cycle-dna-analysis
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    CPT 88182: Flow Cytometry for Cell Cycle / DNA Analysis

    Medicare pays $104 on average nationally for this procedure.

    CPT code 88182 describes a laboratory flow cytometry procedure performed by a lab analyst to analyze the cell cycle or DNA content of a patient specimen (for example, tumor tissue, body fluid, blood, bone marrow, or urine); service type is flow cytometry / laboratory diagnostic analysis, and the typical site of service is clinical laboratory or hospital pathology/laboratory where specimens are processed and analyzed to provide diagnostic and treatment information about malignancy.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with a known history of non-Hodgkin lymphoma presents for evaluation of persistent cytopenias and suspected marrow involvement. Peripheral blood and bone marrow aspirate specimens are sent to the clinical laboratory. The lab analyst performs a flow cytometry DNA/cell cycle analysis (88182) on the bone marrow specimen to assess DNA content, ploidy, and cell cycle distribution to help characterize tumor proliferation and to support diagnosis, prognosis, and treatment planning. The workflow includes specimen accessioning, sample preparation (nuclear staining and fixation), instrument setup and calibration, acquisition of events, gating to identify malignant cell populations, data analysis of DNA histogram and cell cycle phases, and generation of a signed report. Results are used by the hematology/oncology team to correlate with morphologic review, immunophenotyping, cytogenetics, and molecular testing for comprehensive malignancy evaluation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88182Flow cytometry; cell cycle analysis (DNA)Primary code describing the laboratory analysis of DNA/cell cycle performed on specimens such as blood, bone marrow, or body fluids.
    88184Flow cytometry for minimal residual disease (MRD)Performed when sensitive detection of residual neoplastic cells is needed following therapy; may be ordered alongside DNA/cell cycle analysis for comprehensive assessment.
    88165Flow cytometry, up to 8 colors/parameters, per cell populationImmunophenotyping by flow cytometry often accompanies DNA analysis to define malignant cell populations and lineage.
    88240Flow cytometry, each additional marker (when applicable)Used when additional markers are required beyond base panels to characterize malignant populations in conjunction with DNA analysis.
    88305Level III surgical pathology, gross and microscopic examMorphologic review of bone marrow or tissue biopsy complements flow cytometry data in diagnostic workflow.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    363LA2200X
    207L00000X
    2470A2800X
    2083A0100X
    1835S0206X
    251F00000X
    344800000X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-88184-FLOW-CYTOMETRY-TECHNICAL-FIRST-MARKER

    CPT 88184: Flow Cytometry, Single Marker (Technical Component)

    CPT-88185-FLOW-CYTOMETRY-TECHNICAL-COMPONENT-ADD-ON-MARKER

    CPT 88185: Flow Cytometry, Additional Marker Technical Component

    CPT-88187-FLOW-CYTOMETRY-INTERPRETATION-2-TO-8-MARKERS

    CPT 88187: Flow Cytometry Interpretation, 2–8 Markers

    CPT-88188-FLOW-CYTOMETRY-INTERPRETATION-9-15-MARKERS

    CPT 88188: Flow Cytometry Interpretation, 9–15 Markers

    CPT-88189-FLOW-CYTOMETRY-INTERPRETATION-16-OR-MORE-MARKERS

    CPT 88189: Flow Cytometry Interpretation, 16+ Markers

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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