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    OpenPayerBilling CodesPhenotype and Genotype-Infectious AgentsCPT cpt-87902-hepatitis-c-genotype-nucleic-acid-testing-technical
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    CPT 87902: Hepatitis C Virus Genotype by Nucleic Acid Analysis

    CPT code 87902 describes a laboratory technical test for determining the hepatitis C virus genotype by nucleic acid analysis of a patient specimen; the service is a molecular/genetic diagnostic assay performed in a clinical laboratory or reference lab setting and supports clinical decision-making about HCV management and antiviral therapy selection.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient with known chronic hepatitis C infection presents for genotype testing to guide antiviral therapy selection. The clinician collects a peripheral blood specimen (serum or plasma) which is sent to the molecular diagnostics laboratory. The laboratory analyst performs nucleic acid-based testing to determine the hepatitis C virus (HCV) genotype and subgenotype using validated molecular methods (for example, RT-PCR with sequencing or genotype-specific probes). Results are reported to the ordering provider and entered into the electronic medical record to inform direct-acting antiviral regimen choice and duration. Typical site of service is an independent clinical laboratory, hospital outpatient laboratory, or reference laboratory performing specialized molecular diagnostics.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87520Infectious agent detection by nucleic acid (e.g., hepatitis C), amplified probe technique, direct probe technique, or non-amplified probe technique; qualitative, single step methodUsed for HCV RNA qualitative detection that may precede or accompany genotype testing to confirm active viremia.
    87522Infectious agent detection by nucleic acid (e.g., hepatitis C), amplified probe technique; quantificationUsed for HCV RNA viral load testing to quantify viremia, essential for baseline assessment and treatment monitoring alongside genotype.
    0042UHepatitis C virus genotype by next-generation sequencing, report of genotype and resistance-associated substitutions (laboratory test)Performed in advanced molecular workflows to detect genotype and resistance mutations; may complement or replace traditional genotyping.
    87810Infectious agent antigen detection by immunoassay technique; hepatitis C antibody, screeningInitial screening test for prior HCV exposure; a positive result typically leads to nucleic acid testing and genotyping.
    G0472Hepatitis C screening, laboratory test for RNA, single step methodAlternative or payer-specific code used in some screening workflows before genotype testing.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207LP2900X
    207Q00000X
    208D00000X
    246ZE0600X
    207U00000X
    231HA2400X
    207ZF0201X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B17.10Acute hepatitis C without hepatic coma
    B17.11Acute hepatitis C with hepatic coma
    B18.2Chronic viral hepatitis C
    B18.9Chronic viral hepatitis, unspecified
    B19.20Unspecified viral hepatitis C without hepatic coma
    B19.21Unspecified viral hepatitis C with hepatic coma
    D64.9Anemia, unspecified
    E83.00Disorder of copper metabolism, unspecified
    F10.20Alcohol dependence, uncomplicated
    F11.20Opioid dependence, uncomplicated

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-87900-VIRAL-DRUG-SUSCEPTIBILITY-GENOTYPIC-PHENOTYPE-PREDICTION

    CPT 87900: Viral Drug Susceptibility and Phenotype Prediction

    CPT-87901-HIV-1-GENOTYPE-REVERSE-TRANSCRIPTASE-PROTEASE-ANALYSIS

    CPT 87901: HIV‑1 Genotype — Protease and Reverse Transcriptase Sequencing

    CPT-87903-HIV-1-DRUG-RESISTANCE-NUCLEIC-ACID-ANALYSIS

    CPT 87903: HIV-1 Drug Resistance Testing, Culture-Based

    CPT-87904-HIV-1-DRUG-RESISTANCE-ADDITIONAL-DRUG-TESTING

    CPT 87904: HIV‑1 Drug Resistance Test, Additional Drug

    CPT-87905-ENZYMATIC-ACTIVITY-TESTING-INFECTIOUS-AGENT-TECHNICAL

    CPT 87905: Enzymatic Activity Test for Non-Viral Infectious Agents

    CPT-87906-HIV-1-GENOTYPE-NUCLEIC-ACID-NON-RT-PROTEASE-REGIONS

    CPT 87906: HIV‑1 Genotype by Nucleic Acid (non-RT/protease)

    CPT-87910-CMV-GENOTYPE-NUCLEIC-ACID-ANALYSIS

    CPT 87910: CMV Genotype Analysis by Nucleic Acid Testing

    CPT-87912-HEPATITIS-B-GENOTYPE-ANALYSIS-NUCLEIC-ACID

    CPT 87912: Hepatitis B Virus Genotype Analysis

    CPT-87913-SARS-COV-2-GENOTYPE-ANALYSIS-NEXT-GENERATION-SEQUENCING

    CPT 87913: SARS–CoV–2 Genotype Analysis by Next‑Generation Sequencing

    CPT-87999-UNLISTED-MICROBIOLOGY-PROCEDURE

    CPT 87999: Unlisted Microbiology Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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