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    v1.0.28
    OpenPayerBilling CodesMicrobiology Culture and Typing ProceduresCPT cpt-87158-organism-characterization-advanced-microbiology
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    CPT 87158: Organism Typing After Isolation

    CPT code 87158 describes laboratory analysis performed on a previously isolated and identified organism using methods other than those in 87140–87153 to further categorize the organism, such as typing to a taxonomic type level; this service is a microbiology identification/typing procedure typically performed in a clinical or public health laboratory (inpatient or outpatient laboratory settings) as part of organism characterization and epidemiologic or diagnostic workup.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult hospitalized for a complicated bacterial infection in which a cultured organism has been isolated and initially identified (for example, a nonfermenting gram-negative bacillus or unusual streptococcal species). The treating team requests further subtyping to the taxonomic level of type (for epidemiology, infection control, outbreak investigation, or antimicrobial stewardship). A clinical laboratory analyst receives the previously isolated and identified organism and performs a specialized analysis using methods not listed in codes 87140–87153 (for example, advanced phenotypic assays or specific antigenic typing assays). The workflow includes: receipt of the isolate, review of prior identification and susceptibility data, performance of the specialized assay, documentation of results in the laboratory information system, and communication of the refined taxonomic categorization to the ordering clinician and infection control.

    Typical site of service: hospital clinical microbiology laboratory, public health laboratory, or reference laboratory.

    Typical patient scenario: a 68-year-old inpatient with healthcare-associated pneumonia from whom a sputum culture yielded an uncommon Pseudomonas isolate; initial ID in the hospital lab indicates a Pseudomonas species and the clinician requests further typing to determine type/strain for outbreak tracking and therapeutic guidance. The laboratory performs the specified non-listed method to categorize the organism more specifically and reports the type-level result to the clinical team and infection prevention staff.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87070Aerobic culture, bacterial, enhanced recovery and isolation of coloniesPerformed before 87158 to isolate the organism that will undergo further typing.
    87103Identification of organisms; gram stain and microscopic evaluation (if listed)Initial organism identification procedures that precede more specific taxonomic categorization.
    87491Infectious agent detection by nucleic acid (DNA or RNA), amplified probe technique, qualitative, specific organismMolecular tests often performed alongside or instead of 87158 for species or strain-level identification.
    87631Infectious agent detection by nucleic acid (e.g., molecular panels)Alternative advanced methods that may complement or follow 87158 in workflow.
    87477Infectious agent antigen detection by immunoassayAntigenic assays may be used as the specific non-listed method to categorize organisms for type-level identification.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RR0500XRheumatology PhysicianAn internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, comm…
    363LF0000XFamily Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    1835G0000XDeactivated - Pharmacist
    343900000XNon-emergency Medical Transport (VAN)A land vehicle with a capacity to meet special height, clearance, access, and seating, for the conveyance of persons in non-emergency situations. The …
    207SG0205XPh.D. Medical Genetics PhysicianA medical geneticist works in association with a medical specialist, is affiliated with a clinical genetics program and serves as a consultant to medi…
    102X00000XPoetry TherapistA medical or mental health professional who has attained credentials after satisfactorily completing a poetry therapy training program approved by the…
    207RA0001XAdvanced Heart Failure and Transplant Cardiology PhysicianSpecialists in Advanced Heart Failure and Transplant Cardiology would participate in the inpatient and outpatient management of patients with advanced…
    2279P1005XPulmonary Rehabilitation Registered Respiratory TherapistThe respiratory therapist can assist the chronic pulmonary patient in returning to an optimal role in society by providing an effective program. It i…

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    87086-CULTURE-BACTERIAL-QUANTITATIVE-COLONY-COUNT

    CPT 87086: Urine Culture with Quantitative Colony Count

    CPT-87040-BLOOD-CULTURE-ISOLATION-PRESUMPTIVE-IDENTIFICATION

    CPT 87040: Blood Bacterial Culture with Isolation and Presumptive ID

    CPT-87045-AEROBIC-BACTERIAL-STOOL-CULTURE-SALMONELLA-SHIGELLA

    CPT 87045: Aerobic Bacterial Stool Culture for Salmonella/Shigella

    CPT-87046-AEROBIC-BACTERIAL-STOOL-CULTURE-PRESUMPTIVE-ID-NON-SALMONELLA-SHIGELLA

    CPT 87046: Aerobic Bacterial Stool Culture, Presumptive ID (non-Salmonella/Shigella)

    CPT-87070-AEROBIC-CULTURE-ISOLATION-PRESUMPTIVE-IDENTIFICATION

    CPT 87070: Aerobic Culture with Isolation and Presumptive Identification

    CPT-87071-AEROBIC-QUANTITATIVE-BACTERIAL-CULTURE-NON-URINE-BLOOD-STOOL

    CPT 87071: Quantitative Aerobic Bacterial Culture, Non-urine/blood/stool

    CPT-87073-ANAEROBIC-CULTURE-NONBLOOD-NONURINE-NONSTOOL

    CPT 87073: Anaerobic Culture, Non-Urine/Blood/Stool

    CPT-87075-ANAEROBIC-CULTURE-IDENTIFICATION-NON-BLOOD-SPECIMEN

    CPT 87075: Anaerobic Culture and Bacterial Identification (Nonblood)

    CPT-87076-ANAEROBIC-ISOLATE-DEFINITIVE-IDENTIFICATION

    CPT 87076: Anaerobic Isolate Identification to Species Level

    CPT-87077-DEFINITIVE-IDENTIFICATION-AEROBIC-ISOLATE

    CPT 87077: Definitive Identification of Aerobic Isolate

    Showing 1–10 of 30

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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