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    OpenPayerBilling CodesInoculation and Concentration ProceduresCPT cpt-87003-animal-inoculation-observation-necropsy
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    CPT 87003: Animal Inoculation, Observation, and Dissection

    CPT code 87003 describes a laboratory procedure in which a lab analyst inoculates a small animal, observes the animal for a specific reaction, and dissects the test animal upon death; this is a microbiology/infectious disease experimental animal inoculation and observation service typically performed in a laboratory or research facility setting for diagnostic or investigative purposes.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A clinical laboratory performing biological assay research receives a specimen requiring in vivo testing using a small laboratory animal (commonly a mouse or rat). A laboratory analyst inoculates a test animal with a suspected infectious agent, toxin, vaccine, antiserum, or biologic preparation to observe for a specific reaction (for example, pathogenicity, neutralization, or protection). The analyst monitors the animal for development of the targeted reaction over the required observation period. If the test protocol specifies, the analyst performs necropsy/dissection of the test animal upon death (or at a scheduled endpoint) to confirm findings, obtain tissues for histology or culture, and document pathologic changes. Typical workflow steps: specimen receipt and accessioning, preparation of inoculum, animal inoculation under approved protocols, serial observation and documentation of clinical signs, euthanasia or necropsy at endpoint, gross dissection, sample collection, and final reporting of results. Typical site of service is a research or diagnostic laboratory with animal biosafety facilities (animal vivarium or specialized laboratory). Typical patient scenario: a laboratory scientist assesses neutralizing activity of a vaccine candidate by inoculating mice, observing for protection or disease, and dissecting animals at endpoint to verify tissue-level effects.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87003The lab analyst inoculates a small animal and observes for a specific reaction, then dissects the test animal upon death.Primary procedure: in vivo inoculation, observation, and necropsy as described.
    88305Level IV surgical pathology, gross and microscopic examination.May be used for histologic examination of tissues collected at necropsy to provide diagnostic interpretation.
    87205Smear, primary source with interpretation; wet mount for infectious agents.May be used for immediate microscopic examination of fluids or tissue imprints collected during dissection.
    87075Cultivation and isolation of organisms from specimen; identification procedures.May be used for culture and identification of pathogens recovered from necropsy specimens.
    88312Special stains (e.g., immunohistochemistry) for microorganisms, per specimen.May be used adjunctively to identify organisms or antigen distribution in tissue sections from necropsy specimens.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    1223G0001X
    208000000X
    207L00000X
    103T00000X
    207RG0100X
    2084N0402X
    2080P0205X
    322D00000X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    CPT-87015-SPECIMEN-INFECTIOUS-AGENT-CONCENTRATION

    CPT 87015: Concentration Procedure for Infectious Agent

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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