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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86645-cmv-igm-immunoassay
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    CPT 86645: CMV IgM Antibody Immunoassay

    CPT code 86645 describes a laboratory immunoassay performed to detect Cytomegalovirus (CMV) immunoglobulin M (IgM) antibodies in a patient’s blood, a clinical serology test used to evaluate recent or acute CMV infection; service type: diagnostic immunoassay/serology; typical site of service: clinical laboratory or hospital laboratory performing blood-based infectious disease testing.

    For related coverage guidance, see recent payer policy updates: Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policy, Allergy Testing and Injections, Allergy Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old pregnant woman presents to the obstetrics clinic at 10 weeks' gestation with a history of recent febrile illness and flu-like symptoms and concerns about possible exposure to Cytomegalovirus (CMV) from a toddler in daycare. The obstetrician orders a maternal serologic panel including CMV IgM to evaluate for recent primary CMV infection, which can have implications for fetal risk. Venipuncture is performed in the outpatient lab; a serum specimen is processed and routed to the clinical immunology lab. The laboratory analyst performs an immunoassay to detect CMV-specific immunoglobulin M (IgM) antibodies using a validated automated platform. Results are reported in the electronic medical record and communicated to the ordering obstetrician. If the result is positive or equivocal, reflex testing for CMV IgG and IgG avidity or polymerase chain reaction (PCR) testing of maternal blood or amniotic fluid may be ordered to further determine timing and significance of infection. Typical sites of service include outpatient physician offices, hospital outpatient laboratories, and independent clinical diagnostic laboratories. This test is commonly billed for pregnant patients, neonates with suspected congenital infection, and immunocompromised adults with signs of acute CMV disease.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipuncturePerformed immediately prior to 86645 to obtain the serum specimen for CMV IgM testing.
    86644Cytomegalovirus (CMV) antibody, IgG, immunoassayCommonly ordered alongside 86645 to determine immune status (IgG) and help interpret IgM results for acute versus past infection.
    86641Epstein-Barr virus (EBV) antibody, IgM, immunoassayMay be ordered in differential evaluation of mononucleosis-like illness when considering other viral etiologies in the same clinical workup.
    87529Infectious agent detection by nucleic acid (DNA or RNA); CMV, direct probe techniqueUsed when nucleic acid testing (e.g., PCR) is indicated to detect CMV DNA for confirmatory testing, viral load, or testing amniotic fluid.
    87489Infectious agent antigen; multiple organisms (if applicable)Performed when a broader multiplex panel or confirmatory antigen testing is part of the diagnostic workup.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207RC0001XClinical Cardiac Electrophysiology PhysicianA field of special interest within the subspecialty of cardiovascular disease, specialty of Internal Medicine, which involves intricate technical proc…
    405300000XPrevention ProfessionalPrevention Professionals work in programs aimed to address specific patient needs, such as suicide prevention, violence prevention, alcohol avoidance,…
    2085R0203XTherapeutic Radiology PhysicianTherapeutic Radiology certificate name was changed to Radiation Oncology. Use Radiation Oncology.
    176P00000XFuneral DirectorA person, usually an embalmer, whose business is to arrange for the burial or cremation of the dead and to assist at the funeral rites.
    225XR0403XDriving and Community Mobility Occupational TherapistOccupational therapists can optimize and prolong an older driver's ability to drive safely and ease the transition to other forms of transportation if…
    243U00000XRadiology Practitioner AssistantA Radiology Practitioner Assistant (RPA) is a health professional certified as a registered radiographer with the American Registry of Radiologic Tech…

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policybcbsvermont2026-11-01
    Allergy Testing and InjectionsUnitedHealthcare2026-10-01
    Allergy TestingProvidence Health Plan2026-10-01
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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