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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86381-mitochondrial-antibody-eia
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    CPT 86381: Mitochondrial Antibody Test (EIA)

    CPT code 86381 describes a lab immunoassay to detect mitochondrial antibodies (for example, M2) in a patient specimen, typically performed by enzyme immunoassay (EIA) to aid diagnosis of primary biliary cholangitis (PBC); service type is infectious/immunologic serologic testing and the typical site of service is a clinical laboratory or hospital laboratory using serum or other appropriate specimens.

    For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old woman presents to hepatology clinic with progressive fatigue, pruritus, and mildly elevated alkaline phosphatase on routine chemistry. The hepatologist suspects autoimmune cholestatic liver disease and orders serologic testing, including a mitochondrial antibody panel to detect anti-mitochondrial antibodies (especially M2 subtype). A phlebotomy sample of serum is collected in the outpatient laboratory and shipped to a clinical immunology laboratory where an enzyme immunoassay (EIA) is performed. Results reporting documents presence or absence of mitochondrial antibodies; a positive anti‑M2 supports a diagnosis of primary biliary cholangitis (PBC) and informs prognosis and further management such as referral to hepatology, imaging, and possible ursodeoxycholic acid therapy. Typical site of service is an outpatient clinic or hospital outpatient laboratory; ordering providers commonly include gastroenterologists, hepatologists, and primary care physicians. Billing uses the immunology/laboratory service CPT code 86381 for the mitochondrial antibody assay, with laboratory technical and, if applicable, professional components documented per institutional billing policy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80076Hepatic function panelCommon laboratory panel ordered with 86381 to assess liver enzymes and cholestatic pattern.
    84460Thyroid stimulating hormone (TSH)Often ordered in workup of fatigue and abnormal liver tests as part of differential diagnosis.
    83020Hemoglobin; glycosylated (A1c)Ordered in general chronic disease evaluation when metabolic contributors are considered.
    87086Culture, bacterial; quantitative colony countMay be ordered if infectious cholangitis is a concern in the clinical workflow.
    83516Albumin; urine or serumSerum albumin is part of assessing synthetic liver function during evaluation for PBC.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    208VP0014XInterventional Pain Medicine PhysicianInterventional Pain Medicine is the discipline of medicine devoted to the diagnosis and treatment of pain and related disorders principally with the a…
    204D00000XNeuromusculoskeletal Medicine & OMM PhysicianThe Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine physician directs special attention to the neuromusculoskeletal system and its…
    204R00000XElectrodiagnostic Medicine PhysicianElectrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairm…
    133NN1002XNutrition Education NutritionistDietary & Nutritional Service Providers · Nutritionist
    363LC1500XCommunity Health Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B18.2Chronic viral hepatitis C
    B18.9Chronic viral hepatitis, unspecified
    D89.9Disorder involving the immune mechanism, unspecified
    E83.10Disorder of iron metabolism, unspecified
    E83.39Other disorders of phosphorus metabolism
    K70.30Alcoholic cirrhosis of liver without ascites
    K74.4Secondary biliary cirrhosis
    K74.60Unspecified cirrhosis of liver
    K74.69Other cirrhosis of liver
    K75.81Nonalcoholic steatohepatitis (NASH)

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01
    Allergy Testinguniverahealthcare2026-07-16
    Omalizumab (Xolair) and related biologics coverageMass General Brigham Health Plan2026-07-01
    Xolair (omalizumab) (Subcutaneous) — Concomitant therapy restrictions and dosing guidanceeocco2026-07-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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