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    v1.0.28
    OpenPayerBilling CodesHematology and Coagulation ProceduresCPT cpt-85380-ultrasensitive-d-dimer-plasma-assay
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    CPT 85380: D-dimer Ultrasensitive Plasma Assay

    CPT code 85380 describes an ultrasensitive laboratory assay performed on patient plasma to measure D-dimer levels, a quantitative hematology coagulation test used to assess fibrin degradation products; this service is typically a laboratory diagnostic test performed in a clinical laboratory or hospital laboratory setting and reported by the lab analyst who processes the plasma specimen.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male presents to the emergency department with acute onset unilateral calf pain and shortness of breath. The emergency physician orders venous duplex ultrasound of the lower extremity and laboratory testing to evaluate for venous thromboembolism. A blood specimen is collected in sodium citrate and sent to the hospital clinical laboratory. The lab analyst performs an ultrasensitive D‑dimer assay on the patient plasma to determine D‑dimer concentration using an automated immunoassay platform. Results are used by the treating team to help rule out pulmonary embolism or deep vein thrombosis when pretest probability is low to moderate. Typical workflow: specimen receipt and accessioning, centrifugation to obtain platelet‑poor plasma, running the ultrasensitive D‑dimer assay, verification of quality controls, and result reporting to the electronic medical record and ordering provider. Typical site of service is the hospital clinical laboratory or an independent clinical laboratory supporting emergency, inpatient, and outpatient settings.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85380D‑dimer; ultrasensitive assayPrimary procedure: quantitative ultrasensitive D‑dimer testing on patient plasma.
    36415Collection of venous blood by venipunctureOften performed immediately before 85380 to obtain the specimen for D‑dimer testing.
    85025Complete blood count (CBC) with automated differentialCommonly ordered alongside D‑dimer to assess for anemia or infection in the ED workup.
    36416Collection of capillary blood specimenAlternative specimen collection method when venipuncture is difficult; precedes lab testing.
    85610Prothrombin time (PT)Frequently ordered with D‑dimer when evaluating coagulation status in suspected VTE.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    111NN1001XNutrition ChiropractorChiropractic Nutrition is that specialty within the chiropractic profession that deals with the overall factors that affect the patient's ability to m…
    2082S0099XPlastic Surgery Within the Head and Neck (Plastic Surgery) PhysicianA plastic surgeon with additional training in plastic and reconstructive procedures within the head, face, neck and associated structures, including c…
    193200000XMulti-Specialty GroupA business group of one or more individual practitioners, who practice with different areas of specialization.
    1835G0303XGeriatric PharmacistA pharmacist who is certified in geriatric pharmacy practice is designated as a "Certified Geriatric Pharmacist" (CGP). To become certified, candidat…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B34.9Viral infection, unspecified
    D50.9Iron deficiency anemia, unspecified
    D65Disseminated intravascular coagulation [defibrination syndrome]
    E78.5Hyperlipidemia, unspecified
    E87.1Hypo-osmolality and hyponatremia
    I26.99Other pulmonary embolism without acute cor pulmonale
    I74.01Saddle embolus of abdominal aorta
    I74.3Embolism and thrombosis of arteries of the lower extremities
    I80.201Phlebitis and thrombophlebitis of unspecified deep vessels of right lower extremity

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-85002-BLEEDING-TIME-TEST-LABORATORY

    CPT 85002: Bleeding Time Test, Technical Component

    CPT-85004-AUTOMATED-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85004: Automated White Blood Cell Differential

    CPT-85007-MANUAL-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85007: Manual Differential White Blood Cell Count

    CPT-85008-BLOOD-SMEAR-MORPHOLOGIC-REVIEW-NO-DIFFERENTIAL

    CPT 85008: Microscopic Blood Smear Examination, No Differential

    CPT-85009-MANUAL-WBC-COUNT-BUFFY-COAT

    CPT 85009: Manual White Blood Cell Count Using Buffy Coat

    CPT-85013-MICROHEMATOCRIT-TEST-LABORATORY-DIAGNOSTIC

    CPT 85013: Microhematocrit Test by Tube Centrifugation

    CPT-85014-HEMATOCRIT-VOLUME-PERCENT-RED-BLOOD-CELLS

    CPT 85014: Hematocrit (Volume Percent of Red Blood Cells)

    CPT-85018-HEMOGLOBIN-ASSAY-WHOLE-BLOOD

    CPT 85018: Hemoglobin Measurement in Whole Blood

    CPT-85025-COMPLETE-BLOOD-COUNT-CBC

    CPT 85025: Complete Blood Count (CBC)

    CPT-85027-COMPLETE-BLOOD-COUNT-HGB-HCT

    CPT 85027: Complete Blood Count with Hemoglobin and Hematocrit

    Showing 1–10 of 99

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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