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    v1.0.28
    OpenPayerBilling CodesHematology and Coagulation ProceduresCPT cpt-85347-activated-clotting-time-physical-activation
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    CPT 85347: Activated Clotting Time, Physical Activation Method

    CPT code 85347 describes a laboratory test that measures the time for a blood clot to form using a physical activation method (an activated clotting time assay); this is a hemostasis/coagulation test typically performed by a clinical laboratory technologist on a patient blood specimen and is commonly provided in hospital laboratories, outpatient pathology labs, and perioperative or point-of-care settings to assess anticoagulation status and guide clinical management.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old outpatient receiving anticoagulation management or preoperative evaluation who requires assessment of intrinsic pathway clotting function using a physically activated method. The clinician (primary care physician, hematologist, or preoperative clinic provider) orders the assay when monitoring unfractionated heparin therapy, evaluating unexplained bleeding or thrombosis, or assessing coagulation status prior to invasive procedures. A phlebotomy technologist draws a citrate-anticoagulated blood specimen and sends it to the laboratory. In the lab, a medical laboratory scientist or technologist performs the test using a mechanical/physical activation method to initiate clot formation and measures the clotting time. Results are reviewed by a pathologist or laboratory director if abnormal; critical values are relayed to the ordering clinician. Typical sites of service include hospital inpatient laboratories, outpatient hospital laboratories, community hospital clinical labs, and reference laboratory facilities. The service is billed by the performing laboratory under the specified CPT code for this clotting time test using physical activation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85610Prothrombin time; also known as protime (PT) and international normalized ratio (INR)Common complementary coagulation test assessing the extrinsic pathway; often ordered alongside the activated clotting time for broader coagulation evaluation.
    85320Prothrombin time, partial thromboplastin time, thrombin time panels (panel code)Panel codes may be used when multiple coagulation assays are ordered together in the same clinical workup.
    85730Platelet function testPerformed when platelet function disorders or drug effects are suspected in addition to clotting time assessments.
    84460D-dimerOrdered when evaluating for thromboembolic disease in conjunction with clotting tests.
    85349Coagulation time, other methodsRelated coagulation assays using alternative activation methods; used when different activation reagents or methods are required.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2080P0008XPediatric Neurodevelopmental Disabilities PhysicianA pediatrician who specializes in the treatment of individuals with developmental delays and learning disorders associated with cerebral palsy, spina …
    2251S0007XSports Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Sports Physical Therapy, who has demo…
    2471V0106XVascular-Interventional Technology Radiologic TechnologistA radiologic technologist who specializes in vascular interventional and is appropriately educated and trained, consistent with nationally recognized …
    163WD0400XDiabetes Educator Registered NurseNursing Service Providers · Registered Nurse
    156F00000XTechnician/TechnologistA broad category grouping different kinds of technologists and technicians. See individual definitions.
    2083A0300XAddiction Medicine (Preventive Medicine) PhysicianA physician engaged in the subspecialty practice of Addiction Medicine who specializes in the prevention, evaluation, diagnosis, treatment, and recove…
    363LP2300XPrimary Care Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    363AS0400XSurgical Physician AssistantPhysician Assistants & Advanced Practice Nursing Providers · Physician Assistant

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-85002-BLEEDING-TIME-TEST-LABORATORY

    CPT 85002: Bleeding Time Test, Technical Component

    CPT-85004-AUTOMATED-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85004: Automated White Blood Cell Differential

    CPT-85007-MANUAL-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85007: Manual Differential White Blood Cell Count

    CPT-85008-BLOOD-SMEAR-MORPHOLOGIC-REVIEW-NO-DIFFERENTIAL

    CPT 85008: Microscopic Blood Smear Examination, No Differential

    CPT-85009-MANUAL-WBC-COUNT-BUFFY-COAT

    CPT 85009: Manual White Blood Cell Count Using Buffy Coat

    CPT-85013-MICROHEMATOCRIT-TEST-LABORATORY-DIAGNOSTIC

    CPT 85013: Microhematocrit Test by Tube Centrifugation

    CPT-85014-HEMATOCRIT-VOLUME-PERCENT-RED-BLOOD-CELLS

    CPT 85014: Hematocrit (Volume Percent of Red Blood Cells)

    CPT-85018-HEMOGLOBIN-ASSAY-WHOLE-BLOOD

    CPT 85018: Hemoglobin Measurement in Whole Blood

    CPT-85025-COMPLETE-BLOOD-COUNT-CBC

    CPT 85025: Complete Blood Count (CBC)

    CPT-85027-COMPLETE-BLOOD-COUNT-HGB-HCT

    CPT 85027: Complete Blood Count with Hemoglobin and Hematocrit

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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