Summary & Overview
CPT 84307: Somatostatin Assay, Blood
CPT code 84307 designates a laboratory assay to measure somatostatin levels in patient blood. As a specialized hormone test, it supports diagnosis and management of neuroendocrine disorders and related clinical conditions. Nationally, accurate coding of such assays matters for clinical reporting, claims processing, and appropriate lab service classification.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the code’s clinical purpose, typical sites of service, and how it fits into laboratory service delivery. The publication outlines benchmarking and coverage context where available, highlights common billing considerations, and summarizes relevant clinical context for ordering and reporting the assay.
The briefing is intended for billing professionals, laboratory managers, and clinicians who need a clear, national-level summary of CPT code 84307, its clinical role, and the topics usually addressed in payer coverage and reimbursement discussions.
Billing Code Overview
CPT code 84307 describes a laboratory assay performed by a lab analyst to measure the hormone somatostatin in patient blood. The service is a clinical diagnostic laboratory test used to quantify circulating somatostatin levels, typically for evaluation of neuroendocrine function or related clinical indications.
Service Type: Laboratory — clinical chemistry / hormone assay
Typical Site of Service: Clinical laboratory or hospital pathology/laboratory department
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Clinical & Coding Specifications
Clinical Context
A typical adult patient presents to an outpatient endocrinology clinic with symptoms of abdominal pain, steatorrhea, unexplained weight loss, and intermittent hypoglycemia. The clinician suspects a functional neuroendocrine tumor or a peptide-secreting endocrine disorder and orders biochemical testing, including a somatostatin assay, to help characterize circulating hormone levels. A phlebotomy technician collects a venous blood specimen, labels it per laboratory policy, and sends it to the clinical laboratory. The laboratory analyst performs 84307 testing using an immunoassay method, documents assay controls and calibration, and reports quantitative somatostatin concentration to the ordering provider. Results are reviewed by the endocrinologist to aid in differential diagnosis of somatostatinoma, other neuroendocrine tumors, or functional endocrine disorders and to guide further imaging and management decisions.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when reporting only the laboratory professional interpretation when split billing applies. |
52 | Reduced services |