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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84154-free-prostate-specific-antigen-free-psa
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    CPT 84154: Free Prostate-Specific Antigen (free PSA) Assay

    CPT code 84154 describes a laboratory assay to measure free prostate-specific antigen (free PSA) concentration in a patient specimen (typically serum) to evaluate prostate disease risk; this is a clinical laboratory test usually performed in a diagnostic laboratory or hospital clinical lab setting as part of prostate cancer screening or diagnostic evaluation.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a man aged 50–75 referred by his primary care physician or urologist for serum prostate cancer risk assessment after an elevated total prostate‑specific antigen (PSA) or an abnormal digital rectal exam. A blood specimen is collected in the outpatient clinic or laboratory; the specimen is sent to the clinical laboratory where a lab technologist or medical technologist performs an immunoassay to quantify free prostate‑specific antigen (free PSA). Results are reported to the ordering provider and incorporated into clinical decision‑making for prostate cancer screening, repeat testing, or referral for prostate biopsy. Typical sites of service include outpatient clinics, outpatient phlebotomy centers, hospital outpatient laboratories, and independent clinical laboratories. Common clinical workflow steps: patient encounter and order entry; phlebotomy and specimen labeling; specimen transport and accessioning in the lab; analytic testing for free PSA; result verification and release; provider review and patient counseling.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    84153Prostate specific antigen (PSA); totalOften ordered alongside free PSA to calculate percent free PSA and assess prostate cancer risk.
    80053Comprehensive metabolic panel; 14 testsCommonly ordered in the same encounter to assess baseline metabolic status before biopsy or treatment.
    85025Blood count; complete CBC with automated differentialFrequently obtained during urology workup or prior to invasive procedures such as biopsy.
    88172Cytopathology, gross and microscopic examination, for non-gynecologic specimensMay be performed on prostate biopsy samples following abnormal risk assessment (contextual downstream service).
    88305Pathology examination, surgical pathology, gross and microscopic, intermediate complexityUsed for histologic evaluation of prostate biopsy specimens after decision to biopsy based on PSA metrics.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    208M00000XHospitalist PhysicianHospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
    208800000XUrology PhysicianA urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    335V00000XPortable X-ray and/or Other Portable Diagnostic Imaging SupplierA supplier that provides one or more of the following portable services, including but not limited to, x-ray, electrocardiogram (EKG), long-term EKG (…
    207VE0102XReproductive Endocrinology PhysicianAn obstetrician/gynecologist who is capable of managing complex problems relating to reproductive endocrinology and infertility.
    385HR2065XChild Physical Disabilities Respite CareA facility or distinct part of a facility that providers short term, residential care to children, diagnosed with complex or profound disabilities as …

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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