Summary & Overview
CPT 82757: Semen Fructose Measurement, Laboratory Test
CPT code 82757 identifies the laboratory measurement of fructose in semen, a diagnostic assay used to evaluate seminal vesicle function and contribute to the assessment of male infertility. The test quantifies a monosaccharide normally present in seminal fluid and can assist clinicians in distinguishing obstructive from nonobstructive causes of low sperm parameters.
This national-level overview covers common payers including Aetna, Blue Cross Blue Shield, Cigna, UnitedHealthcare, and Medicare. Readers will find a concise explanation of the clinical context for the assay, the typical laboratory setting where the service is performed, and the primary payers that commonly reimburse the test. The publication outlines typical billing considerations and common modifiers associated with laboratory services where available, and highlights what information is and is not available in the input data.
Readers will learn key benchmarks and policy-relevant points for planning and coding: the clinical purpose of the assay, expected sites of service, and the payer landscape addressed in this analysis. Data not available in the input is clearly noted where applicable.
Billing Code Overview
CPT code 82757 describes a laboratory measurement of fructose in semen, a simple sugar normally present in seminal fluid. The test assesses seminal fructose concentration, which can provide clinical information about seminal vesicle function and certain causes of male infertility.
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Service type: Laboratory diagnostic test
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Typical site of service: Clinical laboratory or hospital laboratory setting
Clinical & Coding Specifications
Clinical Context
A 34-year-old man presents to a reproductive urology clinic for infertility evaluation after 12 months of unprotected intercourse without conception. The patient provided a semen specimen collected after 2–5 days of abstinence. The laboratory performs a comprehensive semen analysis including sperm count, motility, morphology, and seminal biochemistry. The laboratory analyst performs 82757 to measure seminal fructose concentration to assess seminal vesicle function and confirm presence of accessory gland secretions. Results are interpreted alongside semen volume, pH, and sperm parameters. An absent or low seminal fructose level supports diagnoses such as bilateral absence or obstruction of the vas deferens/ejaculatory ducts or seminal vesicle dysfunction, while normal levels make those causes less likely. Typical workflow: specimen receipt and accessioning in the andrology/laboratory department, macroscopic semen evaluation, aliquot for biochemical testing, performance of 82757 by a trained lab technologist or clinical chemist, result entry into the laboratory information system, and communication of findings to the ordering reproductive urologist or infertility specialist for clinical correlation and next-step management.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component |