CPT code 82248 represents a laboratory test that measures direct (conjugated) bilirubin in blood. This test is clinically important for evaluating liver excretory function, detecting cholestasis or biliary obstruction, and monitoring hepatic disease progression or response to therapy. As a routine chemistry assay, it is widely used across outpatient laboratories, hospital labs, and ambulatory care settings, making it a common component of liver function testing panels nationwide.

Key payers covered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for use of CPT code 82248, typical sites of service, and the common billing modifiers associated with laboratory services. The publication outlines payer coverage patterns and benchmark considerations where available, and summarizes policy considerations that affect lab testing reimbursement and claims processing for direct bilirubin measurement.

Intended takeaways include: what CPT code 82248 denotes clinically and operationally, how the test fits into diagnostic workflows, which major payers commonly cover the service, and where to look for payer-specific coverage rules and billing guidance. Data not available in the input will be noted where applicable.