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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82157-androstenedione-quantitative-assay
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    CPT 82157: Androstenedione Quantitative Assay

    CPT code 82157 describes a quantitative laboratory assay for the androgenic steroid androstenedione, used as part of the clinical evaluation of hyperandrogenism and suspected congenital adrenal hyperplasia; the service is a clinical laboratory hormone test typically performed on a blood specimen in an outpatient laboratory or hospital clinical laboratory setting.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old cisgender female presents to an endocrinology clinic with a 6-month history of irregular menses, acne, and increasing facial hair. The clinician performs a focused history and physical exam, orders baseline laboratory testing to evaluate for hyperandrogenism, and collects a blood specimen for measurement of serum androstenedione. The blood draw occurs in an outpatient phlebotomy clinic or hospital outpatient lab. The specimen is processed in the clinical laboratory by an analyst who performs a quantitative assay for androstenedione (CPT 82157) to help distinguish ovarian versus adrenal sources of excess androgens and to aid in the workup of suspected congenital adrenal hyperplasia, polycystic ovary syndrome, or adrenal neoplasm. The laboratory result is reviewed by the ordering clinician and incorporated into the diagnostic assessment, with additional hormonal tests ordered as needed (for example, testosterone, DHEA-S, 17-hydroxyprogesterone) and imaging if an adrenal or ovarian source is suspected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80048Basic metabolic panel (BMP)Frequently ordered alongside hormone testing to assess metabolic status and screen for contributing conditions.
    84403Thyroid stimulating hormone (TSH)Often ordered in endocrine evaluations to exclude thyroid dysfunction contributing to menstrual irregularity.
    82627Testosterone; totalCommonly ordered with androstenedione to characterize androgen excess and determine ovarian vs adrenal source.
    82625Dehydroepiandrosterone sulfate (DHEA-S)Helpful to distinguish adrenal from ovarian androgen production; commonly ordered with androstenedione.
    8427017-hydroxyprogesteroneOrdered when congenital adrenal hyperplasia is suspected; used with androstenedione in adrenal evaluations.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    251J00000XNursing Care AgencyA Nursing Care Agency is an entity that provides skilled nursing care through the services of a Registered Nurse (RN) or a Licensed Practical Nurse (L…
    2080P0008XPediatric Neurodevelopmental Disabilities PhysicianA pediatrician who specializes in the treatment of individuals with developmental delays and learning disorders associated with cerebral palsy, spina …
    343900000XNon-emergency Medical Transport (VAN)A land vehicle with a capacity to meet special height, clearance, access, and seating, for the conveyance of persons in non-emergency situations. The …
    103TW0100XDeactivated - Psychotherapy Women

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E03.8Other specified hypothyroidism
    E03.9Hypothyroidism, unspecified
    E16.2Hypoglycemia, unspecified
    E25.0Congenital adrenogenital disorders associated with enzyme deficiency
    E25.9Adrenogenital disorder, unspecified
    E27.8Other specified disorders of adrenal gland
    E28.1Androgen excess
    E28.2Polycystic ovarian syndrome
    E29.1Testicular hypofunction
    E34.9Endocrine disorder, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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