CPT code 81595 describes a laboratory service in which a lab analyst performs real-time quantitative PCR on a peripheral blood subfraction targeting 20 genes and applies an algorithmic analysis combining patient data and test results to generate a rejection risk score for a potential heart transplant candidate; the service type is molecular diagnostic testing with algorithmic/clinical decision support, typically performed in an acute care hospital laboratory or specialized molecular diagnostics reference lab.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.