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    v1.0.28
    OpenPayerBilling CodesCPT cpt-81436-molecular-genomic-testing-deleted-2024
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    CPT 81436: Molecular Pathology/Gene Analysis (Deleted)

    Commercial payers pay $646 on average nationally for this procedure.

    CPT code 81436 was a molecular pathology procedure code used for high-complexity gene analysis and related molecular diagnostic testing; the code is marked as deleted effective 2024-12-31 and therefore represents a discontinued molecular pathology service typically performed in a clinical laboratory or hospital laboratory setting.

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    National Reimbursement Benchmarks

    For CPT 81436 the average commercial benchmark (BUCA) sits at $646.20, indicating a mid-to-upper market commercial expectation for this molecular test. Blue Cross Blue Shield shows a lower central tendency (median $467.90) with a mean of $499.30, while Cigna and UnitedHealth Group exhibit substantially higher central tendencies (median $853.40 and $614.20, respectively), reflecting payer-specific valuation differences across commercial contracts.

    Dispersion (P75 minus P25) highlights variability: Blue Cross Blue Shield’s interquartile range is $145.00 ($539.40 - $409.40), BUCA’s is $144.00 ($665.80 - $520.60), Cigna’s is $117.00 ($853.40 - $678.70), and UnitedHealth Group’s is $146.20 ($731.10 - $584.90). UnitedHealth Group and Blue Cross Blue Shield show the widest IQRs (~$146), while Cigna is the tightest at $117, with BUCA nearly tied to Blue Cross Blue Shield.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with a recent diagnosis of invasive colorectal adenocarcinoma presents to a hospital-based molecular diagnostics laboratory for tumor genomic profiling to assess actionable somatic variants and hereditary cancer risk. The oncology team has ordered comprehensive next-generation sequencing of tumor tissue to evaluate microsatellite instability, KRAS/NRAS/BRAF mutational status, and broader genomic alterations to guide systemic therapy selection and clinical trial eligibility. The clinical workflow includes: tissue retrieval from the pathology laboratory, DNA extraction, library preparation, high-throughput sequencing, bioinformatics analysis, and a molecular pathology report routed to the treating medical oncologist. Preauthorization and medical necessity documentation reference the cancer diagnosis C18.0‑C18.8, C19, C20, C21.1, C21.2, C21.8, C54.0‑C54.3, C54.8. Billing uses the specified sequencing procedure code, with potential modifiers applied for professional component, reduced services, or unusual difficulty. Typical sites of service are hospital outpatient departments, independent clinical laboratories, and academic medical center molecular pathology labs.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    none documentedData not available in the input.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207SG0201XClinical Genetics (M.D.) PhysicianA clinical geneticist demonstrates competence in providing comprehensive diagnostic, management and counseling services for genetic disorders.
    207SC0300XClinical Cytogenetics PhysicianA clinical cytogeneticist demonstrates competence in providing laboratory diagnostic and clinical interpretive services dealing with cellular componen…
    207SG0202XClinical Biochemical Genetics PhysicianA clinical biochemical geneticist demonstrates competence in performing and interpreting biochemical analyses relevant to the diagnosis and management…
    207SG0203XClinical Molecular Genetics PhysicianA clinical molecular geneticist demonstrates competence in performing and interpreting molecular analyses relevant to the diagnosis and management of …
    2080P0214XPediatric Pulmonology PhysicianA pediatrician dedicated to the prevention and treatment of all respiratory diseases affecting infants, children and young adults. This specialist is …
    2085D0003XDiagnostic Neuroimaging (Radiology) PhysicianA licensed physician, who has completed a residency program in Neurology, and who has additional training, experience, and competence in the standards…
    231HA2500XAssistive Technology Supplier AudiologistSpeech, Language and Hearing Service Providers · Audiologist
    2471M2300XMammography Radiologic TechnologistA radiologic technologist who specializes in mammography and is appropriately educated and trained, consistent with nationally recognized standards, s…

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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