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CPT 66225: Scleral Graft Repair for Uveal Prolapse

CPT code 66225 represents surgical repair for uveal tissue prolapse through a thinned or stretched sclera using a scleral graft. This ophthalmic reconstructive procedure addresses structural defects of the globe that result from trauma or progressive disease and can be essential to preserve ocular integrity and prevent further complications. Nationally, accurate coding of this procedure matters for clinical documentation, surgical quality measurement, and payer adjudication for complex ocular surgery.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise briefing on the clinical context of the procedure, typical sites of service, and the types of benchmarks and policy topics relevant to coverage and reimbursement for complex ophthalmic reconstruction. The publication summarizes common billing considerations, expected places of service, and where to look for related coding guidance.

This summary is intended to give clinicians, coders, and policy professionals a clear picture of what CPT code 66225 denotes, why correct use of the code affects care pathways and payment, and what topics to review when evaluating coverage and coding compliance for scleral graft repair of uveal prolapse.

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Billing Code Overview

CPT code 66225 describes surgical repair of an area of the eye where uveal tissue has abnormally protruded through a stretched and thinned area of the sclera. The procedure involves implanting an appropriately sized scleral graft to correct the protrusion caused by trauma or disease.

Service Type: Ophthalmic reconstructive surgery

Typical Site of Service: Hospital operating room or ambulatory surgery center

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CPT 66225: Scleral Graft Repair for Uveal Prolapse

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Billing Code Overview

Service Type: Ophthalmic reconstructive surgery

Typical Site of Service: Hospital operating room or ambulatory surgery center

Clinical & Coding Specifications

Clinical Context

A 56-year-old patient presents with an area of scleral thinning and uveal prolapse after blunt ocular trauma with progressive protrusion of uveal tissue through the weakened sclera. The ophthalmic surgeon documents focal scleral ectasia with exposed uveal tissue, visual axis involvement, and risk for infection or further tissue loss. Preoperative evaluation includes visual acuity, intraocular pressure measurement, slit-lamp exam, dilated fundus exam, and ocular imaging as needed. The procedure performed is surgical repair of the scleral defect with placement of an appropriately sized scleral graft to reestablish globe integrity and cover the uveal prolapse. Typical intraoperative steps include peritomy and exposure of the scleral defect, excision or repositioning of prolapsed uveal tissue as indicated, sizing and suturing of donor scleral graft material, watertight closure, and hemostasis. Postoperative care includes topical antibiotics and steroids, intraocular pressure monitoring, and follow-up visits to assess graft integration, wound healing, and visual rehabilitation. This procedure is commonly performed in an ambulatory surgery center or hospital operating room under monitored anesthesia care or general anesthesia, depending on patient factors and concurrent procedures.

Coding Specifications

Modifier	Description	When to Use
`22`	Increased procedural services	When work, time, and effort substantially exceed typical for scleral graft placement (document rationale).
`26`	Professional component	When only the surgeon’s professional component is billed separate from technical facility charges.
`50`	Bilateral procedure	When identical scleral graft repairs are performed on both eyes during the same operative session.
`51`	Multiple procedures	When other distinct ophthalmic procedures are performed the same day in addition to the scleral graft repair.
`52`	Reduced services	When the procedure is intentionally partially reduced or not completed (document reason).
`53`	Discontinued procedure	When procedure is started but discontinued due to unforeseen circumstances (document reason).
`62`	Two surgeons	When two surgeons work together as primary surgeons on distinct, substantive parts of the procedure.
`66`	Surgical team approach	When a surgical team (multiple qualified surgeons) performs concurrent components of care.
`78`	Unplanned return to OR	For a return to the operating room for a related procedure during the postoperative global period.
`79`	Unrelated procedure or service by same physician during postoperative period	When an unrelated procedure is performed during the global period (not in modifier list but commonly relevant).

Taxonomy Code	Specialty	Notes
207P00000X	Ophthalmology	Ocular surgeons who perform scleral repairs and grafting.
207K00000X	Oculoplastic Surgery	Surgeons managing scleral/ocular surface reconstruction and adjacent tissue repair.
207V00000X	Retina/Vitreous Specialist	Involved when posterior segment evaluation or combined posterior procedures are required.
207Y00000X	Corneal and External Disease	Providers managing scleral thinning related to exposure, infection, or autoimmune disease.
208000000X	General Surgery (Ophthalmic subspecialists)	Occasionally involved for complex ocular trauma with multi-disciplinary needs.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`H44.9`	Disorder of globe, unspecified	General category for globe disorders when more specific code not assigned; may underlie scleral compromise.
`H44.8`	Other disorders of globe	Includes specific globe pathologies leading to scleral thinning or ectasia requiring repair.
`S05.2`	Injury of sclera and corneoscleral laceration	Direct traumatic injury causing scleral defect and uveal prolapse necessitating graft repair.
`H15.2`	Scleritis	Inflammatory scleral disease that can cause thinning and uveal exposure requiring surgical reinforcement.
`H18.89`	Other corneal disorders (including thinning/degeneration)	Scleral ectasia or adjacent corneoscleral degenerations that compromise globe integrity.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`66140`	Repair of scleral fistula; with graft	Alternative or related scleral repair technique addressing fistula or leak.
`66170`	Repair of evisceration or enucleation socket, complex; with graft	Performed when globe-sparing repair is not feasible and more extensive reconstruction is required.
`66999`	Unlisted procedure, anterior segment of eye	Used for atypical or highly customized ocular surface or scleral reconstruction when no specific code matches.
`67036`	Vitrectomy, mechanical, pars plana; for removal of vitreous opacities	Performed concurrently if posterior segment intervention is required for trauma-associated intraocular injury.
`65899`	Unlisted procedure, ocular muscles and globe	Coded when additional uncommon globe repair techniques are necessary in the same operative setting.

Related Codes

CPT-66250-ANTERIOR-SEGMENT-WOUND-REPAIR

CPT 66250: Repair of Anterior Segment Wound During Procedure

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`22`	Increased procedural services	When work, time, and effort substantially exceed typical for scleral graft placement (document rationale).
`26`	Professional component	When only the surgeon’s professional component is billed separate from technical facility charges.
`50`	Bilateral procedure	When identical scleral graft repairs are performed on both eyes during the same operative session.
`51`	Multiple procedures	When other distinct ophthalmic procedures are performed the same day in addition to the scleral graft repair.
`52`	Reduced services	When the procedure is intentionally partially reduced or not completed (document reason).
`53`	Discontinued procedure	When procedure is started but discontinued due to unforeseen circumstances (document reason).
`62`	Two surgeons	When two surgeons work together as primary surgeons on distinct, substantive parts of the procedure.
`66`	Surgical team approach	When a surgical team (multiple qualified surgeons) performs concurrent components of care.
`78`	Unplanned return to OR	For a return to the operating room for a related procedure during the postoperative global period.
`79`	Unrelated procedure or service by same physician during postoperative period	When an unrelated procedure is performed during the global period (not in modifier list but commonly relevant).

Taxonomy Code	Specialty	Notes
207P00000X	Ophthalmology	Ocular surgeons who perform scleral repairs and grafting.
207K00000X	Oculoplastic Surgery	Surgeons managing scleral/ocular surface reconstruction and adjacent tissue repair.
207V00000X	Retina/Vitreous Specialist	Involved when posterior segment evaluation or combined posterior procedures are required.
207Y00000X	Corneal and External Disease	Providers managing scleral thinning related to exposure, infection, or autoimmune disease.
208000000X	General Surgery (Ophthalmic subspecialists)	Occasionally involved for complex ocular trauma with multi-disciplinary needs.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`H44.9`	Disorder of globe, unspecified	General category for globe disorders when more specific code not assigned; may underlie scleral compromise.
`H44.8`	Other disorders of globe	Includes specific globe pathologies leading to scleral thinning or ectasia requiring repair.
`S05.2`	Injury of sclera and corneoscleral laceration	Direct traumatic injury causing scleral defect and uveal prolapse necessitating graft repair.
`H15.2`	Scleritis	Inflammatory scleral disease that can cause thinning and uveal exposure requiring surgical reinforcement.
`H18.89`	Other corneal disorders (including thinning/degeneration)	Scleral ectasia or adjacent corneoscleral degenerations that compromise globe integrity.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`66140`	Repair of scleral fistula; with graft	Alternative or related scleral repair technique addressing fistula or leak.
`66170`	Repair of evisceration or enucleation socket, complex; with graft	Performed when globe-sparing repair is not feasible and more extensive reconstruction is required.
`66999`	Unlisted procedure, anterior segment of eye	Used for atypical or highly customized ocular surface or scleral reconstruction when no specific code matches.
`67036`	Vitrectomy, mechanical, pars plana; for removal of vitreous opacities	Performed concurrently if posterior segment intervention is required for trauma-associated intraocular injury.
`65899`	Unlisted procedure, ocular muscles and globe	Coded when additional uncommon globe repair techniques are necessary in the same operative setting.

Related Codes

CPT-66250-ANTERIOR-SEGMENT-WOUND-REPAIR

CPT 66250: Repair of Anterior Segment Wound During Procedure

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.