CPT 64450: Peripheral Nerve Injection with Anesthetic and/or Steroid
Medicare pays $84 and commercial payers pay $397 on average nationally for this procedure.
CPT code 64450 describes injection of an anesthetic agent, steroid, or both administered adjacent to a peripheral nerve or its branch for diagnostic or therapeutic purposes; service type: peripheral nerve injection procedure; typical site of service: outpatient procedure room, ambulatory surgery center, or office-based procedural setting where nerve injections are performed.
For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.
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National Reimbursement Benchmarks
National averages place Blue Cross Blue Shield and BUCA notably above Medicare: Blue Cross Blue Shield’s mean of $611.80 and BUCA’s mean of $396.70 contrast with Medicare’s mean of $83.80, indicating substantial commercial-to-Medicare differentials for CPT 64450. The gap between BUCA and Medicare (mean difference of $312.90) highlights how an average commercial benchmark can sit multiple multiples higher than the Medicare baseline.
Dispersion varies meaningfully across payers. Calculating P75–P25 ranges: Blue Cross Blue Shield shows a wide spread of $231.10, BUCA’s interquartile spread is $133.00, UnitedHealth Group’s is $73.90, Aetna is $84.50, and Cigna is $72.30. Blue Cross Blue Shield is the most dispersed payer, while Cigna and UnitedHealth Group show the tightest interquartile bands among the commercial payers listed.