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    v1.0.30
    OpenPayerBilling CodesIncision/Biopsy Procedures on the UreterCPT cpt-50606-percutaneous-endoluminal-ureter-renal-pelvis-biopsy
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    CPT 50606: Endoluminal Biopsy of Ureter and Renal Pelvis

    Medicare pays $494 on average nationally for this procedure.

    CPT code 50606 describes a non-endoscopic endoluminal biopsy of the ureter and/or renal pelvis performed via a percutaneous route (for example through a nephrostomy catheter) with image guidance using ultrasound and/or fluoroscopy, and includes radiological supervision and interpretation; service type is a percutaneous image-guided urologic biopsy, and the typical site of service is an interventional radiology suite or inpatient/outpatient procedural area where percutaneous renal/ureteral access is performed.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a history of hematuria and a filling defect seen on antegrade pyelography via an existing nephrostomy catheter is evaluated for tissue diagnosis. Cystoscopy and retrograde ureteroscopy are not feasible due to ureteral obstruction and tortuosity. Interventional radiology schedules an image-guided endoluminal biopsy of the renal pelvis/ureter via the existing nephrostomy tract. Under moderate sedation, the provider advances biopsy instruments through the nephrostomy catheter into the renal pelvis under combined fluoroscopic and ultrasound guidance, obtains targeted tissue samples from the endoluminal lesion, and sends specimens to pathology. The procedure includes radiological supervision and interpretation of imaging performed to localize and sample the lesion. Typical sites of service are an interventional radiology suite or hospital outpatient department. This procedure is billed as 50606 and is used when an endoscopic (ureteroscopic) approach is not used and percutaneous/nephrostomy access is the chosen route.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50705Renal and ureteral biopsy, percutaneous, including imaging guidanceMay be used for percutaneous renal pelvis or upper-tract tissue sampling when performed through renal parenchyma rather than strictly endoluminal nephrostomy tract approaches; sometimes performed in the same session for sampling adjacent tissue.
    50390Renal allograft biopsy, percutaneous, with imaging guidanceRelated percutaneous biopsy technique with imaging guidance; technique parallels image-guided sampling principles though for transplant kidneys.
    52000Cystourethroscopy, with or without collection of specimen(s) by brushing or washingPerformed when lower urinary tract evaluation is indicated in the same diagnostic workup for hematuria or suspected urothelial tumor.
    52332Cystourethroscopy, with ureteroscopy and/or pyeloscopy for evaluation (separate procedure)Ureteroscopic evaluation is an alternative endoluminal approach; 50606 is specifically for non-endoscopic (percutaneous/nephrostomy) access when ureteroscopy is not used.
    77012CT guidance for needle placement (eg, biopsy, aspiration)May be reported when CT guidance is used instead of or in addition to fluoroscopy/ultrasound for localization during percutaneous sampling.
    76942Ultrasonic guidance for needle placementReported when real-time ultrasound guidance is used to localize and guide percutaneous instruments during the biopsy; included in 50606 only if payer requires separate reporting of guidance services.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0208X
    282N00000X
    207RH0000X
    243U00000X
    2279H0200X
    246QC1000X
    261QU0200X
    163WA2000X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-50600-URETERAL-INCISION-AND-EXTERNAL-DRAINAGE

    CPT 50600: Ureterotomy with Ureteral Drainage Catheter Placement

    CPT-50605-URETERAL-STENT-PLACEMENT-VIA-URETEROTOMY

    CPT 50605: Ureteral Stent Placement via Ureterotomy

    CPT-50610-OPEN-URETERAL-STONE-REMOVAL-UPPER-URETER

    CPT 50610: Upper Ureterotomy for Stone Removal

    CPT-50620-OPEN-URETEROTOMY-STONE-REMOVAL-MID-URETER

    CPT 50620: Ureterotomy, Middle Third, Stone Removal

    CPT-50630-DISTAL-URETEROTOMY-STONE-EXTRACTION

    CPT 50630: Incision of Lower Ureter for Stone Removal

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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