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    OpenPayerBilling CodesLithotripsy and Ablation Procedures on the KidneyCPT cpt-50592-percutaneous-radiofrequency-ablation-renal-mass
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    CPT 50592: Percutaneous Radiofrequency Ablation of Renal Mass

    Medicare pays $2741 on average nationally for this procedure.

    CPT code 50592 describes percutaneous radiofrequency ablation of one or more small renal masses, a minimally invasive tumor ablation procedure performed using a needle-based radiofrequency applicator; service type: percutaneous image-guided renal mass ablation; typical site of service: hospital outpatient department or ambulatory surgery center.

    For related coverage guidance, see recent payer policy updates: Positron Emission Tomography (PET) - Non-Oncologic Applications, Positron Emission Tomography (PET) Oncologic Applications, Magnetic Resonance Imaging (MRI) of the Prostate.

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with an incidentally discovered 2.5 cm enhancing cortical mass in the right kidney on abdominal CT is evaluated by a urologist and interventional radiologist. The mass is suspicious for small renal cell carcinoma in a patient with significant cardiopulmonary comorbidity that increases surgical risk for partial nephrectomy. After multidisciplinary discussion, the patient is scheduled for percutaneous radiofrequency ablation (RFA) of the renal mass.

    The clinical workflow includes pre-procedure imaging review and informed consent, pre-procedure labs (coagulation panel, basic metabolic panel), and temporary discontinuation or management of anticoagulants as indicated. On the day of the procedure the patient arrives to an outpatient interventional radiology suite or ambulatory surgical center; moderate sedation or monitored anesthesia care is provided per institutional anesthesia assessment. Under CT or ultrasound guidance, the interventional radiologist advances a percutaneous RFA needle into the renal mass, performs thermal ablation of the lesion(s), and obtains post-ablation imaging to confirm adequate ablation zone and exclude immediate complications. The patient is observed in the recovery area; most patients are discharged the same day if stable, with follow-up imaging planned in 1–3 months to assess for residual tumor.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50605Nephrectomy, partial, including partial ureterectomy, when performed; wedge resection of renal cortexOccasionally considered as an alternative definitive surgical treatment for small renal masses when RFA is not appropriate

    77012 | CT guidance for needle placement (e.g., biopsy, aspiration, injection) | May be reported when CT guidance is used for needle placement during percutaneous RFA

    76942 | Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection) | May be reported when ultrasound guidance is used for needle placement during percutaneous RFA

    43246 | Biopsy of gastrointestinal tract; endoscopic, transgastric — (Note: unrelated; omitted)

    76937 | Ultrasound guidance for vascular access — (Note: less applicable; omitted)

    99152 | Moderate sedation services provided by the same physician performing the procedure (initial 15 minutes) — (Note: anesthesia/sedation codes vary) | Use when reporting moderate sedation by the physician per payer policy

    99155 | Moderate sedation services, more complex — (Note: anesthesia/sedation codes vary) | Use if more complex moderate sedation is delivered and reported per payer policy

    10022 | Fine needle aspiration; without imaging guidance | Not typically related — (Note: omitted)

    76937 and other non-relevant codes were not included per instruction to not add unrelated codes.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208U00000X
    207T00000X
    364S00000X
    163WX0106X
    125Q00000X
    225A00000X
    207RE0101X
    247200000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C64.1Malignant neoplasm of right kidney, except renal pelvis
    C64.2Malignant neoplasm of left kidney, except renal pelvis
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C65.9Malignant neoplasm of unspecified renal pelvis
    D41.4Neoplasm of uncertain behavior of bladder
    D44.5Neoplasm of uncertain behavior of pineal gland
    E10.22Type 1 diabetes mellitus with diabetic chronic kidney disease
    E11.22Type 2 diabetes mellitus with diabetic chronic kidney disease
    I12.9Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I13.0Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Radiology/Diagnostic Imaging1 / 2

    10 rows

    PolicyPayerEffective Date
    Positron Emission Tomography (PET) - Non-Oncologic Applicationsuniverahealthcare2026-10-15
    Positron Emission Tomography (PET) Oncologic Applicationsuniverahealthcare2026-10-15
    Magnetic Resonance Imaging (MRI) of the Prostateuniverahealthcare2026-10-15
    Diagnostic and Therapeutic Radiology ServicesUnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Nebraska Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for New Mexico Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion AnalysisUnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for North Carolina Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Kentucky Only)UnitedHealthcare2026-10-01
    Diagnostic Dynamic Spinal Visualization and Vertebral Motion Analysis (for Kansas Only)UnitedHealthcare2026-10-01

    Related Codes

    CPT-50590-EXTRACORPOREAL-SHOCK-WAVE-LITHOTRIPSY-ESWL

    CPT 50590: Extracorporeal Shock Wave Lithotripsy for Kidney/Ureter Stones

    CPT-50593-PERCUTANEOUS-CRYOABLATION-SMALL-RENAL-MASSES

    CPT 50593: Percutaneous Cryoablation of Small Renal Masses

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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