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    OpenPayerBilling CodesPlacement of Interstitial Device(s) for Radiation Therapy GuidanceCPT cpt-49412-fiducial-marker-placement-open-abdominal-pelvic-retroperitoneal
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    CPT 49412: Fiducial Marker or Dosimeter Placement During Open Abdominal/Pelvic/Retroperitoneal Surgery

    Medicare pays $74 on average nationally for this procedure.

    CPT code 49412 describes an add-on surgical service in which the provider places one or more fiducial markers or a dosimeter into targeted soft tissue to guide radiation therapy or measure delivered radiation; the service is performed during another open abdominal, pelvic, or retroperitoneal operative procedure and is classified as an intraoperative surgical guidance procedure with a typical site of service of the operating room during open abdominal, pelvic, or retroperitoneal surgery.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with a partially resected retroperitoneal sarcoma undergoes an open laparotomy for tumor debulking. At the time of the open abdominal procedure the surgical team places multiple fiducial markers into the soft-tissue tumor bed to guide postoperative external-beam radiation therapy. The workflow includes intraoperative localization of the tumor margin, placement of radiopaque fiducials in and around the target volume, confirmation of marker position with intraoperative radiography or fluoroscopy, documentation of number and location of markers in the operative note, and coordination with radiation oncology for simulation and treatment planning. The service is performed contemporaneously with the primary open procedure and reported as an add-on service using 49412 in addition to the primary procedure code for the open abdominal, pelvic, or retroperitoneal operation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    44120Enterectomy, resection of small intestine; single resection and anastomosisExample of an open abdominal resection that could be the primary procedure when fiducials are placed as an add-on.
    48900Excision of retroperitoneal tumor, open; intraperitoneal or extraperitoneal approachPrimary open retroperitoneal tumor excision that may include placement of fiducial markers reported with 49412 as an add-on.
    56100Radical abdominal hysterectomy, with or without removal of tube(s), ovary(ies)An open pelvic oncologic operation during which fiducials for adjuvant radiation could be placed.
    77014Computed tomography guidance for placement of radiation therapy localization/monitoring device (for example, fiducial markers)Imaging-guided percutaneous fiducial placement; alternative to intraoperative open placement and relevant to multidisciplinary planning.
    77295Radiation treatment planning, complex, including dose-volume histograms and image fusionPostoperative radiation planning that uses fiducials placed intraoperatively to define target volumes and setup.
    55875Laparoscopic radical prostatectomy (used here as an example of pelvic surgery where fiducials may be placed in different workflows)Demonstrates a related pelvic oncologic procedure where fiducials can be used for radiation targeting, though 49412 is specific to open abdominal/pelvic/retroperitoneal procedures.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208100000X
    208600000X
    208000000X
    207L00000X
    207K00000X
    207RT0003X
    374J00000X
    163WX0200X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C19Malignant neoplasm of rectosigmoid junction
    C20Malignant neoplasm of rectum
    C22.9Malignant neoplasm of liver, not specified as primary or secondary
    C49.9Malignant neoplasm of connective and soft tissue, unspecified
    C54.9Malignant neoplasm of corpus uteri, unspecified
    C56.9Malignant neoplasm of unspecified ovary
    C61Malignant neoplasm of prostate
    C67.9Malignant neoplasm of bladder, unspecified
    C71.9Malignant neoplasm of brain, unspecified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-49411-ABDOMINAL-FIDUCIAL-OR-DOSIMETER-PLACEMENT

    CPT 49411: Fiducial or Dosimeter Placement for Abdominal Tumor Guidance

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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