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    v1.0.30
    OpenPayerBilling CodesIntroduction Procedures on the PancreasCPT cpt-48400-intraoperative-pancreatic-duct-contrast-study
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    CPT 48400: Intraoperative Pancreatic Duct Contrast Injection

    Medicare pays $95 on average nationally for this procedure.

    CPT code 48400 describes intraoperative injection of contrast dye into the pancreatic duct to perform a ductogram during pancreatic surgery; this is an intraoperative diagnostic radiologic procedure used to assess ductal patency and identify obstructions of pancreatic secretions. Service type: intraoperative diagnostic imaging/contrast injection. Typical site of service: operating room during pancreatic surgery.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing an open or exploratory pancreatic operation — for example, a distal pancreatectomy, pancreatic head resection, or repair of a traumatic pancreatic duct injury. The patient often presents with symptoms or imaging findings consistent with obstructive pancreatopathy, suspected pancreatic duct disruption, chronic pancreatitis with ductal strictures, or intraoperative concern for retained ductal obstruction. Intraoperatively, after exposure of the pancreas, the surgeon cannulates the pancreatic duct and injects radiopaque contrast dye under fluoroscopy to perform a pancreatogram. The imaging confirms ductal patency, identifies strictures or leaks, and guides further operative steps such as ductal repair, pancreaticojejunostomy, stricture dilation, or additional resection. Typical site of service is an operating room in an acute care hospital; the service is physician‑performed, generally by a general surgeon or hepatopancreatobiliary (HPB) surgeon, often with intraoperative radiology/fluoroscopy support and perioperative anesthesia care. Patient monitoring includes standard intraoperative vital signs, fluoroscopic imaging, and documentation of contrast type, volume, and duct cannulation technique.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    48140Pancreaticoduodenectomy (Whipple)Major pancreatic resection often accompanied by intraoperative pancreatography to assess ductal anatomy and anastomosis integrity.
    48145Distal pancreatectomy, with or without splenectomyResection of the pancreatic body/tail where pancreatogram may be used intraoperatively to evaluate ductal involvement or guide resection margins.
    43280Endoscopic retrograde cholangiopancreatography, diagnostic, with or without collection of specimensPreoperative or intraoperative endoscopic assessment of pancreatic duct; may be performed prior to operative pancreatography in select cases.
    47562Laparoscopic cholecystectomy with cholangiographyIntraoperative biliary imaging analogous to pancreatography; often performed in cases with concurrent biliary disease.
    49422Insertion of percutaneous intraperitoneal catheter for drainagePerformed when drainage of pancreatic collections or postoperative management is required after ductal disruption identified by pancreatogram.
    76000Fluoroscopic guidance for needle placement (eg, biopsy, aspiration, or injection)Represents the fluoroscopic imaging component that supports intraoperative pancreatography; may be performed by radiology or operative team.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208800000X
    364S00000X
    363A00000X
    261QE0700X
    231H00000X
    343800000X
    163WL0100X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    E86.0Dehydration
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K29.70Gastritis, unspecified, without bleeding
    K31.89Other diseases of stomach and duodenum
    K57.30Diverticulosis of large intestine without perforation or abscess without bleeding
    K63.89Other specified diseases of intestine
    K86.0Alcohol-induced chronic pancreatitis
    K86.1Other chronic pancreatitis
    K86.2Cyst of pancreas
    K86.3Pseudocyst of pancreas

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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