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    OpenPayerBilling CodesIntroduction Procedures on the StomachCPT cpt-43755-gastric-tube-insertion-and-gastric-secretion-testing
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    CPT 43755: Gastric Acid Secretion Test via Gastric Tube

    Medicare pays $234 on average nationally for this procedure.

    CPT code 43755 describes insertion of a gastric tube with administration of a stimulant to provoke gastric acid secretion and collection of multiple stomach secretions for laboratory analysis; this is a diagnostic gastric acid secretion test typically performed as an outpatient or inpatient endoscopy/procedure in a hospital, ambulatory surgery center, or specialized GI procedure suite where gastric intubation and specimen handling occur.

    For related coverage guidance, see recent payer policy updates: Prior Authorization/Notification - Weight Loss/Appetite Suppression Medication Coverage, Weight Loss - Glucagon-Like Peptide-1 Agonists - Foundayo, Weight Loss - Glucagon-Like Peptide-1 Agonists - Foundayo Benefit Exclusion Overrides Policy BMI ≥35.

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old outpatient with chronic upper abdominal pain and suspected hypochlorhydria is referred for diagnostic gastric analysis. The gastroenterologist performs placement of a nasogastric or orogastric tube, administers a gastric stimulant (commonly pentagastrin or equivalent) to provoke acid secretion, and collects timed gastric aspirates through the tube. Multiple specimens are obtained and sent to the laboratory for volume, pH, and acid concentration analysis to evaluate gastric acid secretory function and guide management for conditions such as Zollinger-Ellison syndrome, chronic gastritis, or unexplained dyspepsia. The procedure typically occurs in an outpatient endoscopy or gastroenterology suite, or an inpatient hospital ward for patients admitted with relevant symptoms. The clinical workflow includes informed consent, tube insertion with position confirmation, administration of the stimulant, serial aspiration and specimen labeling, documentation of volumes and times, sending specimens to the laboratory, and post-procedure monitoring for tolerance and complications such as epistaxis, aspiration, or tube malposition.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43239Esophagogastroduodenoscopy, flexible, diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)May be performed before or after gastric analysis to evaluate mucosa and obtain biopsy if structural disease is suspected
    43752Gastric emptying study (By scintigraphy), four hoursMay be ordered in parallel when assessing gastric function and motility alongside acid secretory testing
    44380Insertion of nasogastric or nasoenteric tube, less than one monthRelated to the mechanical placement of a tube required for gastric aspiration when an enteric tube is placed in a different setting
    81002Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, ketones, etc. (non-microscopic)Not directly related but commonly ordered as part of the pre-procedure workup and monitoring
    99000Handling and/or conveyance of specimen for transfer from office to laboratory (when applicable)Used for billing ancillary specimen handling or courier services related to processing the gastric secretions

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207VG0400X
    207L00000X
    363LA2200X
    2084P0800X
    208000000X
    207SG0205X
    335G00000X
    261QP2000X

    Related Payer Policy Updates

    Specialty: Bariatric & Obesity Management1 / 3

    10 rows

    PolicyPayerEffective Date
    Prior Authorization/Notification - Weight Loss/Appetite Suppression Medication CoverageColorado Rocky Mountain Health Plans2026-10-01
    Weight Loss - Glucagon-Like Peptide-1 Agonists - FoundayoCigna2026-09-01
    Weight Loss - Glucagon-Like Peptide-1 Agonists - Foundayo Benefit Exclusion Overrides Policy BMI ≥35Cigna2026-09-01
    Bariatric SurgeryPremera Bluecross2026-08-01
    Bariatric Surgery (for Kentucky Only)UnitedHealthcare2026-08-01
    Bariatric Surgery (for Nebraska Only)UnitedHealthcare2026-08-01
    Bariatric (weight loss) surgery — coverage criteriaPremera Bluecross2026-08-01
    MassHealth management of anti-obesity medicationswellsense_health_plan2026-07-03
    Metabolic and Bariatric Surgerycaresourcegeorgia2026-07-01
    Metabolic and Bariatric Surgery: Revisioncaresourcegeorgia2026-07-01

    Related Codes

    CPT-43752-NASOGASTRIC-OR-OROGASTRIC-TUBE-PLACEMENT-GASTRIC-ASPIRATION

    CPT 43752: Nasogastric/Orogastric Tube Placement for Gastric Aspiration

    CPT-43753-GASTRIC-INTUBATION-WITH-LAVAGE

    CPT 43753: Gastric Intubation with Lavage

    CPT-43754-DIAGNOSTIC-GASTRIC-LAVAGE-SPECIMEN-COLLECTION

    CPT 43754: Gastric Lavage with Aspiration for Laboratory Analysis

    CPT-43756-PROCEDURE-43756

    CPT 43756: Laparoscopic Removal of Adjustable Gastric Band

    CPT-43757-GASTROINTESTINAL-SURGICAL-PROCEDURE

    CPT 43757: Laparoscopic Gastrostomy or Jejunostomy Tube Placement

    CPT-43761-NASOGASTRIC-OR-OROGASTRIC-DUODENAL-FEEDING-TUBE-PLACEMENT

    CPT 43761: Nasogastric/Orogastric Enteric Tube Placement, Duodenal

    CPT-43762-GASTROSTOMY-TUBE-REMOVAL-AND-REPLACEMENT

    CPT 43762: Gastrostomy Tube Removal and Replacement without Imaging

    CPT-43763-GASTROSTOMY-TUBE-REVISION-AND-REPLACEMENT

    CPT 43763: Gastrostomy Tube Revision and Replacement

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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