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    v1.0.28
    OpenPayerBilling CodesEsophagogastroduodenoscopy ProceduresCPT cpt-43250-egd-with-polypectomy-or-excisional-biopsy
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    CPT 43250: EGD with Removal of Abnormal Mass or Growth

    Medicare pays $518 on average nationally for this procedure.

    CPT code 43250 describes an esophagogastroduodenoscopy (flexible endoscopic examination of the esophagus, stomach, and duodenum) with removal of one or more abnormal masses or growths using a grasping/excisional instrument with cauterization and submission of the specimen for laboratory analysis; service type: diagnostic and therapeutic upper endoscopy with polypectomy; typical site of service: endoscopy suite or hospital outpatient department (procedure performed via insertion through the mouth under appropriate sedation).

    For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with a history of chronic gastroesophageal reflux disease and recent onset of progressive dysphagia is referred for diagnostic and therapeutic upper endoscopy. The provider obtains informed consent and performs sedation in an outpatient endoscopy suite or ambulatory surgical center. A flexible esophagogastroduodenoscope is introduced orally to inspect the esophagus, stomach, and duodenum. During inspection, a 1.2 cm sessile polyp in the antrum is identified. The provider uses a hot snare to grasp, excise, and cauterize the lesion, retrieves the specimen, and submits it to pathology. The patient is recovered from sedation in the PACU and discharged with post-procedure instructions and pathology follow-up. Typical sites of service include the outpatient endoscopy unit, ambulatory surgery center, or hospital endoscopy suite. The service type is diagnostic and therapeutic endoscopy with polypectomy and specimen retrieval for histopathologic analysis.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Esophagogastroduodenoscopy, flexible, transoral; diagnostic, with or without collection of specimen(s) by brushing or washingOften billed when diagnostic EGD is performed without therapeutic excision; may be listed if no polypectomy is performed.
    43239Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multipleBilled when mucosal biopsies are obtained rather than when a polyp is snared and removed; may accompany 43250 if additional biopsies are taken.
    43251Esophagogastroduodenoscopy, flexible, transoral; with removal of tumor(s), polyp(s), or other lesion(s) by hot biopsy forcepsAlternative technique code for polypectomy when hot biopsy forceps used instead of snare.
    43255Esophagogastroduodenoscopy, flexible, transoral; with control of bleeding, any methodPerformed if hemostasis is required during or after polypectomy.
    43248Placement of endoscopic stent in esophagus, stomach, or duodenum (separate code)May be performed in the same session if obstructing lesion requires stenting, though this is a distinct therapeutic intervention.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    333600000XPharmacyA facility used by pharmacists for the compounding and dispensing of medicinal preparations and other associated professional and administrative servi…
    103T00000XPsychologistA psychologist is an individual who is licensed to practice psychology which is defined as the observation, description, evaluation, interpretation, a…
    103TE1000XDeactivated - Psychologist
    246ZX2200XOrthopedic AssistantAn Orthopaedic Assistant is a person who has been trained to work as a physician extender in both clinical and surgical environments. An Orthopaedic A…
    103TP2700XDeactivated - Psychologist Psychotherapy

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C15.9Malignant neoplasm of esophagus, unspecified
    C16.9Malignant neoplasm of stomach, unspecified
    C17.9Malignant neoplasm of small intestine, unspecified
    D13.0Benign neoplasm of esophagus
    D13.1Benign neoplasm of stomach
    D37.5Neoplasm of uncertain behavior of rectum
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.2Esophageal obstruction
    K22.3Perforation of esophagus
    K22.4Dyskinesia of esophagus

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21
    Mm_0579_Coveragepositioncriteria_Anesthesia_Services_Selected_Nerve_BlocksCigna2026-05-15
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01

    Related Codes

    CPT-43210-ESOPHAGOGASTRODUODENOSCOPY-WITH-FUNDOPLICATION

    CPT 43210: Esophagogastroduodenoscopy with Fundoplication

    CPT-43235-DIAGNOSTIC-ESOPHAGOGASTRODUODENOSCOPY-EGD

    CPT 43235: Esophagogastroduodenoscopy, Diagnostic

    CPT-43236-UPPER-ENDOSCOPY-SUBMUCOSAL-INJECTION

    CPT 43236: Esophagogastroduodenoscopy with Submucosal Injection

    CPT-43237-UPPER-ENDOSCOPY-WITH-ENDOSCOPIC-ULTRASOUND-EUS

    CPT 43237: Esophagogastroduodenoscopy with Endoscopic Ultrasound

    CPT-43238-ENDOSCOPIC-ULTRASOUND-FNA-BIOPSY-UPPER-GI

    CPT 43238: Endoscopic Ultrasound with FNA/Biopsy

    CPT-43239-ESOPHAGOGASTRODUODENOSCOPY-WITH-BIOPSY

    CPT 43239: Esophagogastroduodenoscopy with Biopsy

    CPT-43240-ENDOSCOPIC-PSEUDOCYST-DRAINAGE-STENT-PLACEMENT

    CPT 43240: Endoscopic Drainage of Gastrointestinal Pseudocyst

    CPT-43241-UPPER-ENDOSCOPY-WITH-TUBE-OR-CATHETER-PLACEMENT

    CPT 43241: EGD with Enteral Tube or Catheter Placement

    CPT-43242-EUS-GUIDED-FNA-BIOPSY-UPPER-GI

    CPT 43242: EUS-Guided Upper GI Fine Needle Aspiration/Biopsy

    CPT-43243-ENDOSCOPIC-SCLEROTHERAPY-ESOPHAGUS-STOMACH

    CPT 43243: Endoscopic Sclerotherapy of Esophagus/Stomach/Duodenum

    Showing 1–10 of 25

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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