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    v1.0.28
    OpenPayerBilling CodesEsophagoscopy ProceduresCPT cpt-43216-esophagoscopy-flexible-excision-lesion
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    CPT 43216: Flexible Esophagoscopy with Removal of Esophageal Lesion

    Medicare pays $474 on average nationally for this procedure.

    CPT code 43216 describes a flexible esophagoscopy with removal of one or more abnormal masses or growths using a grasping/excising/cauterizing instrument and submission of the specimen to pathology; the service is an endoscopic therapeutic procedure performed via the mouth using a flexible esophagoscope (service type: endoscopic mucosal/surgical removal), typically provided in an endoscopy suite, ambulatory surgical center, or hospital outpatient department (typical site of service: endoscopy suite/ASC/hospital outpatient).

    For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver Disease.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient presents with progressive dysphagia to solids and intermittent odynophagia. Prior barium swallow raised concern for an intraluminal esophageal lesion. The gastroenterologist schedules an outpatient flexible esophagoscopy with endoscopic removal of a suspected benign-appearing polypoid lesion and retrieval of tissue for pathology. The procedure is performed under monitored anesthesia care in an ambulatory endoscopy suite. The provider advances a flexible esophagoscope through the mouth into the esophagus, identifies a 1.5 cm pedunculated mass, deploys a snare with cautery to excise and simultaneously cauterize the base, and retrieves the specimen for histopathologic analysis. Recovery includes short observation, instruction on diet advance, and pathology follow-up. Billing reflects the diagnostic endoscopy with therapeutic removal and specimen submission for laboratory analysis under 43216.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Upper gastrointestinal endoscopy including esophagus, stomach, and either the duodenum with diagnostic evaluation; with biopsy, single or multiplePerformed if additional diagnostic biopsies of the esophagus or stomach are required beyond polypectomy; may be reported when biopsies are taken in addition to polypectomy according to coding guidance.
    43247Endoscopic, transoral removal of tumor(s), polyp(s), or other lesion(s) of the esophagus; with partial esophagectomy and reconstructionUsed for more extensive endoscopic resection involving partial esophagectomy — represents a more extensive therapeutic procedure than 43216.
    43239Endoscopic, transoral esophagectomy, distal esophagus, with anastomosis (complex resections)May be relevant when lesion requires surgical resection beyond endoscopic excision; represents an operative escalation.
    43255Upper gastrointestinal endoscopy with control of bleeding, any methodPerformed when active bleeding is encountered during or after polypectomy and additional hemostatic measures are required.
    43202Diagnostic esophagoscopy, flexible; without biopsyRepresents the purely diagnostic procedure; 43216 is reported specifically for removal of lesion(s) with cauterization and specimen retrieval.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    207RN0300XNephrology PhysicianAn internist who treats disorders of the kidney, high blood pressure, fluid and mineral balance and dialysis of body wastes when the kidneys do not fu…
    207RP1001XPulmonary Disease PhysicianAn internist who treats diseases of the lungs and airways. The pulmonologist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational an…
    2085R0001XRadiation Oncology PhysicianA radiologist who deals with the therapeutic applications of radiant energy and its modifiers and the study and management of disease, especially mali…
    2278P1005XPulmonary Rehabilitation Certified Respiratory TherapistThe respiratory therapist can assist the chronic pulmonary patient in returning to an optimal role in society by providing an effective program. It i…
    102X00000XPoetry TherapistA medical or mental health professional who has attained credentials after satisfactorily completing a poetry therapy training program approved by the…
    332900000XNon-Pharmacy Dispensing SiteA site other than a pharmacy that dispenses medicinal preparations under the supervision of a physician to patients for self-administration. (e.g. phy…
    246XS1301XSonography Specialist/Technologist CardiovascularA cardiovascular sonography technologist operates special equipment to create images and conduct tests of the cardiovascular system. They work with ph…

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C15.3Malignant neoplasm of upper third of esophagus
    C15.4Malignant neoplasm of middle third of esophagus
    C15.9Malignant neoplasm of esophagus, unspecified
    D13.0Benign neoplasm of esophagus
    J38.6Stenosis of larynx
    J98.4Other disorders of lung
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.0Achalasia of cardia
    K22.2Esophageal obstruction
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01
    Celiac Disease TestingOscar Health2026-10-01
    Laboratory Testing for the Diagnosis of Inflammatory Bowel DiseaseOscar Health2026-10-01
    Percutaneous Electrical Nerve Field Stimulation (PENFS)Cigna2026-09-15
    Colorectal Cancer ScreeningBlue Cross Blue Shield - New Mexico2026-09-04

    Related Codes

    CPT-43180-HYPOPHARYNGEAL-CERVICAL-ESOPHAGEAL-DIVERTICULECTOMY-ENDOSCOPIC

    CPT 43180: Rigid Esophagoscopy with Diverticulectomy and Cricopharyngeal Myotomy

    CPT-43191-RIGID-ESOPHAGOSCOPY-ORAL-ENDOSCOPE

    CPT 43191: Rigid Esophagoscopy with Brushing or Washing

    CPT-43192-ESOPHAGEAL-SUBMUCOSAL-INJECTION-RIGID-ENDOSCOPE

    CPT 43192: Esophageal Submucosal Injection via Rigid Endoscope

    CPT-43193-RIGID-ESOPHAGOSCOPY-WITH-BIOPSY

    CPT 43193: Rigid Esophagoscopy with Biopsy

    CPT-43194-RIGID-ESOPHAGOSCOPY-FOREIGN-BODY-REMOVAL

    CPT 43194: Rigid Esophagoscopy with Foreign Body Removal

    CPT-43195-ESOPHAGEAL-BALLOON-DILATION-RIGID-ENDOSCOPE

    CPT 43195: Esophageal Balloon Dilation via Rigid Endoscope

    CPT-43196-RIGID-ESOPHAGOSCOPY-DILATION-GUIDEWIRE-DILATORS

    CPT 43196: Rigid Esophagoscopy with Guidewire and Dilation

    CPT-43197-TRANSNASAL-FLEXIBLE-ESOPHAGOSCOPY-BRUSHING-WASHINGS

    CPT 43197: Flexible Transnasal Esophagoscopy with Brushing

    CPT-43198-FLEXIBLE-NASAL-ESOPHAGOSCOPY-WITH-BIOPSY

    CPT 43198: Transnasal Flexible Esophagoscopy with Biopsy

    CPT-43200-ESOPHAGOGASTRODUODENOSCOPY-BRUSHING-WASHING-CYTOLOGY

    CPT 43200: Endoscopic Brushing or Washing for Specimen Collection

    Showing 1–10 of 28

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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