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    v1.0.30
    OpenPayerBilling CodesEsophagoscopy ProceduresCPT cpt-43201-esophageal-endoscopy-submucosal-injection
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    CPT 43201: Esophageal Endoscopy with Submucosal Injection

    Medicare pays $289 on average nationally for this procedure.

    CPT code 43201 describes a flexible endoscopic procedure in which the provider inserts an endoscope through the mouth into the esophagus and performs one or more injections into the submucosa; service type: endoscopic therapeutic procedure, typical site of service: endoscopy suite or hospital outpatient setting.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to the outpatient endoscopy suite with symptomatic esophageal submucosal lesions and focal bleeding at the gastroesophageal junction refractory to conservative therapy. After pre-procedure evaluation, including history, medication review (anticoagulant management), and informed consent, the patient is prepared for a diagnostic and therapeutic esophagogastroduodenoscopy (EGD) using a flexible endoscope. Under monitored anesthesia care or moderate sedation, the endoscope is inserted through the mouth into the esophagus. The provider identifies the target area and performs one or more submucosal injections (for example, saline with epinephrine, saline with dye, or a submucosal lifting solution) to raise the mucosa for lesion resection, to control localized bleeding, or to create a cushion for subsequent endoscopic mucosal resection (EMR). Post-procedure, the patient is observed in recovery, given discharge instructions, and scheduled for pathology follow-up if tissue was obtained and for routine post- endoscopy care.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43239Esophagoscopy, flexible, transoral; with directed submucosal injection(s), any substanceClosely related: alternative code depending on documentation specifics and payer rules; may represent similar therapeutic injections.
    43235Esophagoscopy, flexible, transoral; with biopsy, single or multipleOften performed in same session when mucosal abnormalities are biopsied in addition to submucosal injection.
    43249Esophagoscopy, flexible, transoral; with removal of foreign body(s)Performed when a retained object is identified during EGD; may be performed before or after injections if needed.
    43254Esophagoscopy, flexible, transoral; with dilation, by crepe or balloonPerformed when esophageal strictures are present; dilation may be performed in same session following diagnostic evaluation.
    43280Esophagoscopy, flexible, transoral; with submucosal tunneling endoscopic resection (STER)Performed in advanced therapeutic cases where submucosal injection is a step toward tunnel creation for lesion resection.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207RC0000X
    207L00000X
    208000000X
    207P00000X
    374T00000X
    2086S0127X
    1223P0300X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.0Achalasia of cardia
    K22.2Esophageal obstruction
    K22.4Dyskinesia of esophagus
    K22.6Gastro-esophageal laceration-hemorrhage syndrome
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K26.9Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K29.70Gastritis, unspecified, without bleeding
    K29.71Gastritis, unspecified, with bleeding
    K31.89Other diseases of stomach and duodenum

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43180-HYPOPHARYNGEAL-CERVICAL-ESOPHAGEAL-DIVERTICULECTOMY-ENDOSCOPIC

    CPT 43180: Rigid Esophagoscopy with Diverticulectomy and Cricopharyngeal Myotomy

    CPT-43191-RIGID-ESOPHAGOSCOPY-ORAL-ENDOSCOPE

    CPT 43191: Rigid Esophagoscopy with Brushing or Washing

    CPT-43192-ESOPHAGEAL-SUBMUCOSAL-INJECTION-RIGID-ENDOSCOPE

    CPT 43192: Esophageal Submucosal Injection via Rigid Endoscope

    CPT-43193-RIGID-ESOPHAGOSCOPY-WITH-BIOPSY

    CPT 43193: Rigid Esophagoscopy with Biopsy

    CPT-43194-RIGID-ESOPHAGOSCOPY-FOREIGN-BODY-REMOVAL

    CPT 43194: Rigid Esophagoscopy with Foreign Body Removal

    CPT-43195-ESOPHAGEAL-BALLOON-DILATION-RIGID-ENDOSCOPE

    CPT 43195: Esophageal Balloon Dilation via Rigid Endoscope

    CPT-43196-RIGID-ESOPHAGOSCOPY-DILATION-GUIDEWIRE-DILATORS

    CPT 43196: Rigid Esophagoscopy with Guidewire and Dilation

    CPT-43197-TRANSNASAL-FLEXIBLE-ESOPHAGOSCOPY-BRUSHING-WASHINGS

    CPT 43197: Flexible Transnasal Esophagoscopy with Brushing

    CPT-43198-FLEXIBLE-NASAL-ESOPHAGOSCOPY-WITH-BIOPSY

    CPT 43198: Transnasal Flexible Esophagoscopy with Biopsy

    CPT-43200-ESOPHAGOGASTRODUODENOSCOPY-BRUSHING-WASHING-CYTOLOGY

    CPT 43200: Endoscopic Brushing or Washing for Specimen Collection

    Showing 1–10 of 28

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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