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    v1.0.30
    OpenPayerBilling CodesOther Procedures on the Salivary Gland and DuctsCPT cpt-42665-intraoral-salivary-duct-ligation
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    CPT 42665: Intraoral Salivary Duct Ligation

    Medicare pays $382 on average nationally for this procedure.

    CPT code 42665 describes an intraoral surgical procedure in which the provider makes an incision inside the mouth to access a salivary duct and ties it off (duct ligation); this represents a minor oral surgical service typically performed in an outpatient ambulatory surgery center or dental/oral surgery clinic under local or general anesthesia.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting with recurrent swelling and pain of the floor of mouth or submandibular gland attributable to chronic obstructive sialadenitis, sialolithiasis, or persistent salivary duct fistula. The patient often reports intermittent swelling that worsens with meals and may have documented stones on ultrasound or CT. After clinical evaluation, conservative measures (hydration, sialogogues, antibiotics if infected) are attempted. When obstruction persists or ductal injury/fistula requires definitive management, the oral surgeon or otolaryngologist schedules an intraoral procedure under local anesthesia with sedation or general anesthesia.

    The procedure involves an intraoral incision to expose the affected salivary duct (typically the submandibular or sublingual duct), identification of the duct proximal to the obstruction or fistula tract, and ligation (tying off) of the duct to eliminate salivary flow through the damaged channel. Hemostasis is obtained and the mucosa is closed primarily. Postoperative workflow includes short observation, analgesia, oral hygiene instructions, and follow-up to monitor for infection, gland atrophy, or persistent symptoms. Typical site of service is an ambulatory surgery center or hospital outpatient department; minor cases may occur in an office procedure room depending on anesthesia level and facility capabilities.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    41899Unlisted procedure, dentoalveolar structuresUsed when a specific oral salivary duct procedure lacks an exact CPT match and customization is needed
    42630Excision of sublingual and submandibular gland (partial or total)Performed when gland excision is required for definitive management after failed ductal procedures
    42650Transoral removal of submandibular sialolith (intraoral)Stone removal that may occur before or instead of duct ligation when sialolithiasis is amenable to extraction
    42990Ligation of salivary fistulaRelated procedure for external or persistent fistula management—may be performed in conjunction or as an alternative
    69210Removal of foreign body from external ear (used as example of minor procedure coding)Data not available in the input.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    2080P0208X
    208000000X
    363L00000X
    243U00000X
    1744P3200X
    207XS0114X
    2084H0002X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    F45.41Pain disorder exclusively related to psychological factors
    I83.90Asymptomatic varicose veins of unspecified lower extremity
    K04.7Periapical abscess without sinus
    K05.6Periodontal disease, unspecified
    K11.3Abscess of salivary gland
    K11.5Sialolithiasis
    K11.6Mucocele of salivary gland
    K11.7Disturbances of salivary secretion
    K11.8Other diseases of salivary glands
    K11.9Disease of salivary gland, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-42550-SIALOGRAPHY-SALIVARY-GLAND-IMAGING

    CPT 42550: Sialography (Radiosialography)

    CPT-42600-SURGICAL-MANAGEMENT-SALIVARY-FISTULA

    CPT 42600: Salivary Fistula Repair/Drainage

    CPT-42650-SALIVARY-DUCT-DILATION-PROBE-INSERTION

    CPT 42650: Salivary Duct Dilation with Probe

    CPT-42660-SALIVARY-DUCT-DILATION-AND-CATHETERIZATION

    CPT 42660: Salivary Duct Dilation and Catheterization

    CPT-42699-SALIVARY-GLAND-DUCT-PROCEDURE-UNLISTED

    CPT 42699: Unlisted Procedure on Salivary Gland or Duct

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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