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    OpenPayerBilling CodesExcision Procedures on the LipsCPT cpt-40527-lip-excision-full-thickness-with-flap-reconstruction
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    CPT 40527: Full-Thickness Lip Excision with Opposing Lip Flap Repair

    Medicare pays $565 on average nationally for this procedure.

    CPT code 40527 describes excision of a full-thickness portion of the lip with closure using a skin flap from the opposite lip, a surgical procedure used to repair large lip defects; this is a reconstructive/dermatologic surgical service typically performed in an outpatient surgical suite or ambulatory surgical center and involves soft tissue reconstruction of the oral commissure or vermilion border.

    For related coverage guidance, see recent payer policy updates: Office-based Laryngeal Procedures, Otoacoustic Emissions Testing (for Oxford Only), Hearing Aids and Devices Including Wearable, Bone-Anchored, and Semi-Implantable (for Indiana Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 67-year-old male presents with a full-thickness defect of the lower lip after wide excision of a biopsy-proven squamous cell carcinoma. The patient is scheduled for surgical repair under monitored anesthesia care. The surgeon performs a full-thickness excision of the involved lip tissue and reconstructs the defect using a mucocutaneous advancement flap from the remaining lip to restore oral competence and cosmesis. Typical workflow: preoperative evaluation and informed consent; lesion excision with appropriate margins; intraoperative confirmation of hemostasis; reconstruction with local flap and layered closure; postoperative recovery in PACU with instructions for wound care, oral intake restrictions, and outpatient follow-up for suture removal and pathology review.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11640Excision, malignant lesion including margins, face, scalp, eyelids, nose, ears, lips; excised diameter 1.1 to 2.0 cmMay be performed at the same operative session as the diagnostic excision or for smaller lesions prior to a larger reconstructive 40527 when staged excision is indicated.
    12051Repair, intermediate, wounds of face, ears, eyelids, nose, lips; 2.6 cm to 7.5 cmUsed for layered closure of partial-thickness lip wounds; selected when defect does not require full-thickness flap as in 40527.
    13131Repair, complex, forehead, cheeks, chin, tum of lip or mouth; 2.6 cm to 7.5 cmMay be used for complex layered repairs when additional reconstructive techniques are applied adjunctively to 40527.
    14040Adjacent tissue transfer or rearrangement, forehead, cheeks, chin, mouth, neck; defect 10 sq cm or lessPerformed when additional local flap tissue is required beyond the lip flap used in 40527.
    88305Level IV pathology, surgical pathology, gross and microscopic examinationUsed for histopathologic examination of the excised specimen(s) removed during the 40527 procedure.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207P00000X
    207L00000X
    207R00000X
    251J00000X
    385H00000X
    163WH0200X
    3336H0001X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C00.3Malignant neoplasm of upper lip, inner aspect
    C00.4Malignant neoplasm of lower lip, inner aspect
    C00.5Malignant neoplasm of lip, unspecified, inner aspect
    C00.9Malignant neoplasm of lip, unspecified
    C02.3Malignant neoplasm of anterior two-thirds of tongue, part unspecified
    C02.4Malignant neoplasm of lingual tonsil
    C02.9Malignant neoplasm of tongue, unspecified
    C04.9Malignant neoplasm of floor of mouth, unspecified
    C06.0Malignant neoplasm of cheek mucosa
    C06.1Malignant neoplasm of vestibule of mouth

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Otorhinolaryngology (ENT)1 / 2

    10 rows

    PolicyPayerEffective Date
    Office-based Laryngeal ProceduresPremera Bluecross2026-10-06
    Otoacoustic Emissions Testing (for Oxford Only)UnitedHealthcare2026-10-01
    Hearing Aids and Devices Including Wearable, Bone-Anchored, and Semi-Implantable (for Indiana Only)UnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking Agents (for Kentucky Only)UnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking Agents (for New Mexico Only)UnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking AgentsUnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking AgentsUnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking Agents (for Nebraska Only)UnitedHealthcare2026-10-01
    Injectable Dermal Fillers and Bulking Agents (for Kansas Only)UnitedHealthcare2026-10-01
    Sinus Surgeries and Interventions (for North Carolina Only)UnitedHealthcare2026-10-01

    Related Codes

    CPT-40490-LIP-BIOPSY-INCISIONAL

    CPT 40490: Incisional Biopsy of Lip

    CPT-40500-VERMILION-BORDER-EXCISION-LIP-LESION

    CPT 40500: Excision of Lesion, Vermilion Border of Lip

    CPT-40510-LIP-WEDGE-EXCISION-CLOSURE

    CPT 40510: Lip Wedge Excision with Simple Suture Closure

    CPT-40520-LIP-LESION-EXCISION-V-SHAPED-INCISION-PRIMARY-CLOSURE

    CPT 40520: Lip Lesion Excision with V‑shaped Incision and Linear Closure

    CPT-40525-LIP-EXCISION-FULL-THICKNESS-WITH-LOCAL-FLAP-CLOSURE

    CPT 40525: Full-Thickness Lip Excision with Local Flap Repair

    CPT-40530-LIP-EXCISION-MORE-THAN-ONE-FOURTH-NO-RECONSTRUCTION

    CPT 40530: Excision of More Than One-Quarter of Lip, No Reconstruction

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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